The Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) is an academic department within the Medical Sciences Division of the University of Oxford. The Department is a rapidly growing community of orthopaedic surgeons, rheumatologists and scientists all working in the field of musculoskeletal disorders.

The teaching, TVCLRN (in collaboration with the NOC), the Oxford Musculoskeletal Biobank team, the Surgical Skills Lab and the central administration team is housed in the new Nuffield Orthopaedic Centre Hospital (NOC).

The research work of the department takes place in the the Botnar Research Centre (and other locations on the NOC site) and the Kennedy Institute of Rheumatology, on the Old Road Campus of the University. It is also supported by the the NIHR Oxford Musculoskeletal Biomedical Research Unit (BRU). The co-location with NHS services puts the department in an excellent position with basic researchers working alongside clinicians. This substantially improves research capacity, improving access for researchers to patients, and facilitating the interaction between clinicians and basic scientists that is essential for successful medical research.

The department makes a significant contribution to the teaching of orthopaedic surgery and trauma to clinical students as well as to postgraduate teaching in orthopaedics and rheumatology. There is also a substantial teaching activity related to the postgraduate education of DPhil students based in the department.The undergraduate teaching is organised in the department's offices and teaching facilities in the John Radcliffe Hospital, and the Director of Graduate studies is based in the Botnar Research Centre.

In 2003, Prof Keith Willett founded the Kadoorie Centre for Critical Care Research, and Education, based at the John Radcliffe Hospital focusing on outcomes of treatment in the injured patient and established the Oxford Trauma Research Group.

Musculoskeletal Sciences have been designated as one of the research priorities of the Medical Sciences Division and in the 2008 Research Assessment Exercise, NDORMS was rated as 4*, the top grade.