Andrew Carr

Andrew Carr

Professor Andrew Carr

ChM DSc FRCS FMedSci

Email: andrew.carr@ndorms.ox.ac.uk

Telephone: 01865 737421

Professor Andy Carr has been the Nuffield Professor of Orthopaedic Surgery and a fellow of Worcester College at the University of Oxford since 2001. He was born in Yorkshire and educated at Bradford Grammar School and Bristol University before undertaking surgical training in Sheffield, Oxford, Seattle and Melbourne. He was a research fellow in metabolic medicine with Roger Smith in Oxford and with Bill Cole at the Royal Children’s Hospital in Melbourne.

In 1992 he was appointed as a consultant surgeon in the NHS and established a shoulder surgery service in Oxford where he has led the development and evaluation of arthroscopic surgical techniques and joint replacement. He has trained over twenty specialist shoulder surgeons and is a past President of the British Elbow and Shoulder Surgery Society.

He was a Non-Executive Director of the Nuffield Orthopaedic Centre NHS Trust from 2001-2011 and Divisional Director from 2011-13 when he led the hospital through its merger to become part of Oxford University Hospitals NHS Trust.

He is Head of the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS). In 2002 he founded and now directs the Botnar Research Centre. The department has significantly expanded under his leadership to 350 scientists and 90 post-graduate students, it includes the Kennedy Institute of Rheumatology which moved from London to Oxford in 2011.

He is an NIHR Senior Investigator and was elected a fellow of the Academy of Medical Sciences in 2009. His awards include the Robert Jones Gold Medal of the British Orthopaedic Association and a Hunterian Professorship of the Royal College of Surgeons of England. He has been a Trustee of Arthritis Research UK, a consultant to the Oxford English Dictionary and a Curator of the Bodleian Libraries.

From 2008 he has been director of the NIHR Musculoskeletal Biomedical Research Unit in Oxford which focuses on translational research in orthopaedics and rheumatology.

Professor Carr’s research is in the fields of evidence-based medicine, clinical and molecular epidemiology and implant development.

He has promoted the involvement of patients in assessing surgical outcomes and, with colleagues in Oxford, developed a range of patient reported outcome measures (PROMs) for orthopaedics. The Oxford Scores have been translated into 20 languages and are now used worldwide. Recently he has focused on understanding the role of placebo controls in surgery and has led a number of large scale randomized clinical trials.

He was a group head at the Wellcome Trust Centre for Human Genetics in Oxford in the 1990’s and has collaborated with other groups in the UK and Europe in the discovery of a number of key genetic loci involved in osteoarthritis. He pioneered the use of patients and families who have undergone joint replacement surgery in these studies.

In the 1990’s he worked with John Goodfellow and John O’Connor during the early development of the Oxford Knee, (Biomet PLC), as a partial knee replacement, it has now been implanted in over a million patients worldwide. He also developed a partial shoulder replacement with Corin PLC (the Oxford Shoulder).

The Oxford Scores and the Oxford Knee were two of the 4* impact statements submitted by the University of Oxford in the REF 2014.

He is currently developing biomaterials that aim to enhance endogenous tissue repair using biophysical cues without the need for growth factors or cells. His group use electrospinning to manufacture novel suture materials (Bioyarn) and surgical meshes (Biopatch).

Publications

View all publications (the list below shows the past five years). Arranged by year. Sorted by date of publication. Sort by title? Where possible, links point to PubMed. Click icon to switch to Europe PubMed Central UK PubMed Central icon

2015

  1. Dean BJ, Snelling SJ, Dakin SG, Javaid MK, Carr AJ. In vitro effects of glutamate and N-methyl-d-aspartate receptor (NMDAR) antagonism on human tendon derived cells. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2015 Jun
  2. Beard D, Rees J, Rombach I, Cooper C, Cook J, Merritt N et al. The CSAW Study (Can Shoulder Arthroscopy Work?) - a placebo-controlled surgical intervention trial assessing the clinical and cost effectiveness of arthroscopic subacromial decompression for shoulder pain: study protocol for a randomised controlled trial. Trials. 2015 May; 1(16): 210. doi: 10.1186/s13063-015-0725-y
  3. Poulsen RC, Carr AJ, Hulley PA. Cell proliferation is a key determinant of the outcome of FOXO3a activation. Biochemical and Biophysical Research Communications. 2015 Apr; 1(462): 78-84. doi: 10.1016/j.bbrc.2015.04.112
  4. Kuzma-Kuzniarska M, Cornell HR, Moneke MC, Carr AJ, Hulley PA. Lovastatin-Mediated Changes in Human Tendon Cells. Journal of cellular physiology. 2015 Apr. doi: 10.1002/jcp.25010
  5. French A, Bravery C, Smith J, Chandra A, Archibald P, Gold JD et al. Enabling consistency in pluripotent stem cell-derived products for research and development and clinical applications through material standards. Stem cells translational medicine. 2015 Mar; 3(4): 217-223. doi: 10.5966/sctm.2014-0233
  6. Edwards AM, Arrowsmith CH, Bountra C, Bunnage ME, Feldmann M, Knight JC et al. Preclinical target validation using patient-derived cells. Nature reviews. Drug discovery. 2015 Mar; 3(14): 149-150. doi: 10.1038/nrd4565
  7. Lorbach O, Baums MH, Kostuj T, Pauly S, Scheibel M, Carr A et al. Advances in biology and mechanics of rotator cuff repair. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. 2015 Feb; 2(23): 530-541. doi: 10.1007/s00167-014-3487-2
  8. Kiran A, Bottomley N, Biant LC, Javaid MK, Carr AJ, Cooper C et al. Variations In Good Patient Reported Outcomes After Total Knee Arthroplasty. The Journal of arthroplasty. 2015 Feb. doi: 10.1016/j.arth.2015.02.039
  9. Carr AJ, Price AJ, Glyn-Jones S, Rees JL. Advances in arthroscopy - Indications and therapeutic applications. Nature Reviews Rheumatology. 2015 Jan; 2(11): 77-85. doi: 10.1038/nrrheum.2014.174
  10. Carr A. Arthroscopic surgery for degenerative knee. BMJ (Clinical research ed.). 2015 Jan: h2983. doi: 10.1136/bmj.h2983
  11. Mouthuy PA, Zargar N, Hakimi O, Lostis E, Carr A. Fabrication of continuous electrospun filaments with potential for use as medical fibres. Biofabrication. 2015 Jan; 2(7): 025006. doi: 10.1088/1758-5090/7/2/025006
  12. Silva M, Daheron L, Hurley H, Bure K, Barker R, Carr AJ et al. Generating iPSCs: translating cell reprogramming science into scalable and robust biomanufacturing strategies. Cell stem cell. 2015 Jan; 1(16): 13-17. doi: 10.1016/j.stem.2014.12.013

2014

  1. Quek L, Otto G, Garnett C, Lhermitte L, Lau I-J, Karamitros D et al. Functional and Genetic Heterogeneity of Distinct Leukemic Stem Cell Populations in CD34-Human Acute Myeloid Leukemia. BLOOD. 2014 Dec; 21(124)
  2. Romero L, Nieuwenhuijse M, Carr A, Sedrakyan A. Review of clinical outcomes-based anchors of minimum clinically important differences in hip and knee registry-based reports and publications. The Journal of bone and joint surgery. American volume. 2014 Dec: 98-103. doi: 10.2106/jbjs.n.00464
  3. Duda GN, Grainger DW, Frisk ML, Bruckner-Tuderman L, Carr A, Dirnagl U et al. Changing the mindset in life sciences toward translation: a consensus. Science translational medicine. 2014 Nov; 264(6): 264cm12. doi: 10.1126/scitranslmed.aaa0599
  4. Palmer AJ, Ayyar-Gupta V, Dutton SJ, Rombach I, Cooper CD, Pollard TC et al. Protocol for the Femoroacetabular Impingement Trial (FAIT): a multi-centre randomised controlled trial comparing surgical and non-surgical management of femoroacetabular impingement. Bone & joint research. 2014 Nov; 11(3): 321-327
  5. Carr AJ, Price AJ, Glyn-Jones S, Rees JL. Advances in arthroscopy-indications and therapeutic applications. Nature reviews. Rheumatology. 2014 Oct. doi: 10.1038/nrrheum.2014.174
  6. Thakkar D, Grant TM, Hakimi O, Carr AJ. Distribution and expression of type VI collagen and elastic fibers in human rotator cuff tendon tears. Connective tissue research. 2014 Oct; 5-6(55): 397-402. doi: 10.3109/03008207.2014.959119
  7. Beard DJ, Harris K, Dawson J, Doll H, Murray DW, Carr AJ et al. Meaningful changes for the Oxford hip and knee scores after joint replacement surgery. Journal of clinical epidemiology. 2014 Oct
  8. Agricola R, Waarsing JH, Thomas GE, Carr AJ, Reijman M, Bierma-Zeinstra SM et al. Response to letter to editor: "Cam impingement: defining the presence of a cam deformity by the alpha angle Data from the CHECK cohort an Chingford cohort". Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2014 Oct. doi: 10.1016/j.joca.2014.09.022
  9. Tilley JM, Murphy RJ, Chaudhury S, Czernuszka JT, Carr AJ. Effect of tear size, corticosteroids and subacromial decompression surgery on the hierarchical structural properties of torn supraspinatus tendons. Bone & joint research. 2014 Aug; 8(3): 252-261. doi: 10.1302/2046-3758.38.2000251
  10. Kynaston-Pearson F, Ashmore AM, Malak TT, Rombach I, Taylor A, Beard D et al. Primary hip replacement prostheses and their evidence base: systematic review of literature. British journal of sports medicine. 2014 Aug; 15(48): 1198. doi: 10.1136/bjsports-2014-f6956rep
  11. Hinsley H, Nicholls A, Daines M, Wallace G, Arden N, Carr A. Classification of rotator cuff tendinopathy using high definition ultrasound. Muscles, ligaments and tendons journal. 2014 Jul; 3(4): 391-397
  12. Thomas GE, Palmer AJ, Batra RN, Kiran A, Hart D, Spector T et al. Subclinical deformities of the hip are significant predictors of radiographic osteoarthritis and joint replacement in women. A 20 year longitudinal cohort study. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2014 Jul
  13. Dawson J, Churchman D, Fitzpatrick R, Carr AJ. THE ASSESSMENT OF SHOULDER INSTABILITY: THE DEVELOPMENT AND VALIDATION OF A QUESTIONNAIRE - THE OXFORD SHOULDER INSTABILITY SCORE (OSIS). VALUE IN HEALTH. 2014 May; 3(17): A51
  14. Carr AJ, Rees JL, Ramsay CR, Fitzpatrick R, Gray A, Moser J et al. Protocol for the United Kingdom Rotator Cuff Study (UKUFF): a randomised controlled trial of open and arthroscopic rotator cuff repair. Bone & joint research. 2014 May; 5(3): 155-160. doi: 10.1302/2046-3758.35.2000270
  15. Cabrera-López C, Ars E, Marti T, Harris PC, Torra R, Clerckx C et al. Renal development and cystic diseases. Nephrol Dial Transplant. 2014 May: iii73-iii78. doi: 10.1093/ndt/gfu141
  16. Franklin SL, Dean BJ, Wheway K, Watkins B, Javaid MK, Carr AJ. Up-regulation of Glutamate in Painful Human Supraspinatus Tendon Tears. The American journal of sports medicine. 2014 May. doi: 10.1177/0363546514532754
  17. Rodriguez-Fontenla C, Calaza M, Gonzalez A, Evangelou E, Ntzani EE, Ioannidis JPA et al. Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies. Arthritis and Rheumatology. 2014 Apr; 4(66): 940-949. doi: 10.1002/art.38300
  18. Snelling S, Kramm A, Yapp C, Carr A, Oppermann U. EPIGENETIC MODIFYING COMPOUNDS ALTER ACTIVITY OF PRIMARY HUMAN ARTICULAR CHONDROCYTES AND MESENCHYMAL STEM CELLS UNDERGOING CHONDROGENESIS. OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S141
  19. Dean BJ, Franklin SL, Murphy RJ, Benson R, Javaid K, Carr AJ. THE NEUROHISTOLOGY OFPAINFUL AND PAIN-FREE ROTATOR CUFF TENDONS: A CASE CONTROL STUDY. OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S420
  20. Vidal-Bralo L, Rodriguez-Fontela C, Calaza M, Oreiro N, Blanco FJ, Carr A et al. NEW FUNCTIONAL MICROSATELLITE ASSOCIATED WITH OSTEOARTHRITIS SUSCEPTIBILITY. OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S232-S233
  21. Davies BM, Hakimi O, El-Sherbini Y, Ye H, Price A, Carr A. PELVIS IS SUPERIOR TO FEMUR AND TIBIA AS A SOURCE FOR MINIMALLY MANIPULATED MESENCHYMAL STEM CELLS. OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S443-S444
  22. Dean BJ, Franklin SL, Murphy RJ, Javaid MK, Carr AJ. Glucocorticoids induce specific ion-channel-mediated toxicity in human rotator cuff tendon: a mechanism underpinning the ultimately deleterious effect of steroid injection in tendinopathy?. British journal of sports medicine. 2014 Mar. doi: 10.1136/bjsports-2013-093178
  23. Smith R, McIlwraith W, Schweitzer R, Kadler K, Cook J, Caterson B et al. Advances in the understanding of tendinopathies: A report on the Second Havemeyer Workshop on equine tendon disease. EQUINE VETERINARY JOURNAL. 2014 Jan; 1(46): 4-9. doi: 10.1111/evj.12128
  24. Brown CP, Carr AJ, Price AJ, Houle M-A, Nicklaus M, Couture C-A et al. Imaging and modeling collagen architecture from the nano to micro scale. Biomedical Optics Express. 2014 Jan; 1(5): 233-243. doi: 10.1364/BOE.5.000233
  25. Judge A, Murphy RJ, Maxwell R, Arden NK, Carr AJ. Temporal trends and geographical variation in the use of subacromial decompression and rotator cuff repair of the shoulder in England. Bone Joint J. 2014 Jan; 1(96): 70-74. doi: 10.1302/0301-620X.96B1.32556
  26. Wartolowska K, Beard DJ, Carr AJ. Attitudes and Beliefs about Placebo Surgery among Orthopedic Shoulder Surgeons in the United Kingdom. PLoS One. 2014; 3(9): e91699. doi: 10.1371/journal.pone.0091699
  27. James SJ, Mirza SB, Culliford DJ, Taylor PA, Carr AJ, Arden NK. Baseline bone mineral density and boneturnover in pre-operative hip and knee arthroplasty patients. Bone Joint Res. 2014; 1(3): 14-19. doi: 10.1302/2046-3758.31.2000218
  28. Poulsen RC, Knowles HJ, Carr AJ, Hulley PA. Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposure. Cell Death Dis. 2014: e1074. doi: 10.1038/cddis.2014.52
  29. Lidgren L, Gomez-Barrena E, N Duda G, Puhl W, Carr A. European musculoskeletal health and mobility in Horizon 2020: Setting priorities for musculoskeletal research and innovation. Bone & joint research. 2014; 3(3): 48-50. doi: 10.1302/2046-3758.33.2000296
  30. Ackermann PW, Franklin SL, Dean BJ, Carr AJ, Salo PT, Hart DA. Neuronal pathways in tendon healing and tendinopathy--update. Frontiers in bioscience (Landmark edition). 2014: 1251-1278. doi: 10.2741/4280
  31. Davies BM, Rikabi S, French A, Pinedo-Villanueva R, Morrey ME, Wartolowska K et al. Quantitative assessment of barriers to the clinical development and adoption of cellular therapies: A pilot study. Journal of tissue engineering. 2014: 2041731414551764. doi: 10.1177/2041731414551764
  32. Wartolowska K, Judge A, Hopewell S, Collins GS, Dean BJ, Rombach I et al. Use of placebo controls in the evaluation of surgery: systematic review. BMJ (Clinical research ed.). 2014: g3253. doi: 10.1136/bmj.g3253

2013

  1. Holt TA, Mant D, Carr A, Gwilym S, Beard D, Toms C et al. Corticosteroid injection for shoulder pain: single-blind randomized pilot trial in primary care. Trials. 2013 Dec; 1(14): 425. doi: 10.1186/1745-6215-14-425
  2. Snelling S, Rout R, Davidson R, Clark I, Carr A, Hulley PA et al. A gene expression study of normal and damaged cartilage in Anteromedial Gonarthrosis, a phenotype of osteoarthritis. Osteoarthritis Cartilage. 2013 Dec. doi: 10.1016/j.joca.2013.12.009
  3. Brindley DA, Davies B, Pinedo-Villanueva R, Wartolowska K, Rooke K, Kramm A et al. The implementation of novel collaborative structures for the identification and resolution of barriers to pluripotent stem cell translation. Stem Cells and Development. 2013 Dec; SUPPL.1(22): 63-72. doi: 10.1089/scd.2013.0403
  4. Kynaston-Pearson F, Ashmore AM, Malak TT, Rombach I, Taylor A, Beard D et al. Primary hip replacement prostheses and their evidence base: Systematic review of literature. BMJ (Online). 2013 Dec. doi: 10.1136/bmj.f6956
  5. Davies BM, Mouthuy P-A, Baboldashti NZ, Hakimi O, Snelling S, Price A et al. Repairing damaged tendon and muscle: Are mesenchymal stem cells and scaffolds the answer?. Regenerative Medicine. 2013 Sep; 5(8): 613-630. doi: 10.2217/rme.13.55
  6. Beard D, Price A, Carr A, Arden N, Cooper C, Davies L et al. Total or Partial Knee Arthroplasty Trial - TOPKAT: Study protocol for a randomised controlled trial. Trials. 2013 Sep; 1(14). doi: 10.1186/1745-6215-14-292
  7. Evangelou E, Ntzani EE, Tsilidis KK, Ioannidis JPA, Metrustry S, Spector TD et al. A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip. Annals of the Rheumatic Diseases. 2013 Aug. doi: 10.1136/annrheumdis-2012-203114
  8. Hakimi O, Mouthuy P-A, Carr A. Synthetic and degradable patches: An emerging solution for rotator cuff repair. International Journal of Experimental Pathology. 2013 Aug; 4(94): 287-292. doi: 10.1111/iep.12030
  9. Agricola R, Waarsing JH, Bierma-Zeinstra SMA, Arden NK, Carr AJ, Thomas GE et al. Cam impingement of the hip-a risk factor for hip osteoarthritis. Nature Reviews Rheumatology. 2013 Jul. doi: 10.1038/nrrheum.2013.114
  10. Murphy RJ, Kliskey K, Wheway K, Watkins EB, Beard DJ, Carr AJ. Age-related changes in the supraspinatus tendon. Br J Sports Med. 2013 Jun; 9(47): e2. doi: 10.1136/bjsports-2013-092459.13
  11. Poulsen RC, Watts AC, Murphy RJ, Snelling SJ, Carr AJ, Hulley PA. Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: In vivo and in vitro evidence. Annals of the Rheumatic Diseases. 2013 Jun. doi: 10.1136/annrheumdis-2012-203146
  12. Palmer AJ, Brown CP, McNally EG, Price AJ, Tracey I, Jezzard P et al. Non-invasive imaging of cartilage in early osteoarthritis. Bone Joint J. 2013 Jun; 6(95-B): 738-746. doi: 10.1302/0301-620X.95B6.31414
  13. Carr A, Cooper C, Murphy R, Watkins B, Wheway K, Rombach I et al. PARot - assessing platelet-rich plasma plus arthroscopic subacromial decompression in the treatment of rotator cuff tendinopathy: Study protocol for a randomized controlled trial. Trials. 2013 Jun; 1(14). doi: 10.1186/1745-6215-14-167
  14. Murphy RJ, Kliskey K, Wheway K, Watkins EB, Beard DJ, Carr AJ. Rotator cuff tendinopathy: immunohistochemical changes across the spectrum of pathology. Br J Sports Med. 2013 Jun; 9(47): e2. doi: 10.1136/bjsports-2013-092459.51
  15. Murphy RJ, Kliskey K, Wheway K, Watkins EB, Beard DJ, Carr AJ. Short term tissue response to current treatments for rotator cuff tendinopathy. Br J Sports Med. 2013 Jun; 9(47): e2. doi: 10.1136/bjsports-2013-092459.35
  16. Poulsen RC, Watts AC, Murphy RJ, Carr AJ, Hulley PA. Glucocorticoids induce senescence in primary human tenocytes: in vitro and in vivo evidence. Osteoarthritis and Cartilage. 2013 Apr: S63-S64. doi: 10.1016/j.joca.2013.02.141
  17. Dean BJ, Franklin SL, Carr AJ. The Peripheral Neuronal Phenotype is Important in the Pathogenesis of Painful Human Tendinopathy: A Systematic Review. Clin Orthop Relat Res. 2013 Apr. doi: 10.1007/s11999-013-3010-y
  18. Murphy RJ, Daines MT, Carr AJ, Rees JL. An independent learning method for orthopaedic surgeons performing shoulder ultrasound to identify full-thickness tears of the rotator cuff. J Bone Joint Surg Am. 2013 Feb; 3(95): 266-272. doi: 10.2106/JBJS.K.00706
  19. de Boer SF, Bouma HW, Pollard TC, Van Kampen PM, Carr AJ, Hogervorst T. Coxa recta, coxa profunda and abductor ratio: hip morphology variants compared in an arthroplasty 
and control population. Hip Int. 2013 Feb: 0. doi: 10.5301/hipint.5000012
  20. Palmer AJ, Thomas GE, Pollard TC, Rombach I, Taylor A, Arden N et al. The feasibility of performing a randomised controlled trial for femoroacetabular impingement surgery. Bone Joint Res. 2013 Feb; 2(2): 33-40. doi: 10.1302/2046-3758.22.2000137
  21. Agricola R, Waarsing JH, Reijman M, Bierma-Zeinstra SMA, Weinans H, Thomas GE et al. Cam impingement: defining the presence of a cam deformity by the alpha angle. Data from the CHECK cohort and Chingford cohort. Osteoarthritis and Cartilage. 2013. doi: 10.1016/j.joca.2013.11.007
  22. Qiu Y, Wang X, Zhang Y, Rout R, Carr AJ, Zhu L et al. Development of a refined tenocyte differentiation culture technique for tendon tissue engineering (vol 197, pg 27, 2013). CELLS TISSUES ORGANS. 2013; 6(198): 469
  23. Pollard TCB, Batra RN, Judge A, Watkins B, McNally EG, Gill HS et al. The hereditary predisposition to hip osteoarthritis and its association with abnormal joint morphology. Osteoarthritis and Cartilage. 2013; 2(21): 314-321
  24. Qiu Y, Zhu L, Wang X, Carr AJ, Xia Z, Sabokbar A et al. In vitro two-dimensional and three-dimensional tenocyte culture for tendon tissue engineering. Journal of Tissue Engineering and Regenerative Medicine. 2013. doi: 10.1002/term.1791
  25. Kendal AR, Prieto-Alhambra D, Arden NK, Carr A, Judge A. Mortality rates at 10 years after metal-on-metal hip resurfacing compared with total hip replacement in England: retrospective cohort analysis of hospital episode statistics. BMJ. 2013: f6549
  26. Worsley P, Warner M, Mottram S, Gadola S, Veeger HEJ, Hermens H et al. Motor control retraining exercises for shoulder impingement: Effects on function, muscle activation, and biomechanics in young adults. Journal of Shoulder and Elbow Surgery. 2013; 4(22): e11-e19
  27. Hudson G, Panoutsopoulou K, Wilson I, Southam L, Rayner NW, Arden N et al. No Evidence Of An Association Between Mitochondrial DNA Variants And Osteoarthritis In 7393 Cases And 5122 Controls. Annals of the Rheumatic Diseases 72(1):136-139 2013
  28. Rout R, McDonnell S, Hulley P, Jayadev C, Khan T, Carr A et al. The pattern of cartilage damage in antero-medial osteoarthritis of the knee and its relationship to the anterior cruciate ligament. Journal of Orthopaedic Research. 2013; 6(31): 908-913
  29. Dean BJF, Lostis E, Oakley T, Rombach I, Morrey ME, Carr AJ. The risks and benefits of glucocorticoid treatment for tendinopathy: A systematic review of the effects of local glucocorticoid on tendon. Seminars in Arthritis and Rheumatism. 2013. doi: 10.1016/j.semarthrit.2013.08.006
  30. Birkmeyer JD, Reames BN, McCulloch P, Carr AJ, Campbell WB, Wennberg JE. Understanding of regional variation in the use of surgery. The Lancet. 2013; 9898(382): 1121-1129. doi: 10.1016/S0140-6736(13)61215-5
  31. Dean BJF, Gwilym SE, Carr AJ. Why does my shoulder hurt? A review of the neuroanatomical and biochemical basis of shoulder pain. British Journal of Sports Medicine. 2013

2012

  1. Qiu Y, Wang X, Zhang Y, Carr AJ, Zhu L, Xia Z et al. Development Of A Refined Tenocyte Expansion Culture Technique For Tendon Tissue Engineering. J Tissue Eng Regen Med. 2012 Sep. doi: 10.1002/term.1597
  2. Elliott KS, Chapman K, Day-Williams A, Panoutsopoulou K, Southam L, Lindgren CM et al. Evaluation Of The Genetic Overlap Between Osteoarthritis With Body Mass Index And Height Using Genome-Wide Association Scan Data. Ann Rheum Dis. 2012 Sep. doi: 10.1136/annrheumdis-2012-202081
  3. arcOGEN Consortium and arcOGEN Collaborators. Identification Of New Susceptibility Loci For Osteoarthritis (Arcogen): A Genome-Wide Association Study. Lancet. 2012 Jul. doi: 10.1016/S0140-6736(12)60681-3
  4. Dean BJ, Franklin SL, Carr AJ. A systematic review of the histological and molecular changes in rotator cuff disease. Bone Joint Res. 2012 Jul; 7(1): 158-166. doi: 10.1302/2046-3758.17.2000115
  5. Rodriguez-Fontenla C, Carr A, Gomez-Reino JJ, Tsezou A, Loughlin J, Gonzalez A. ASSOCIATION OF A BMP5 MICROSATELLITE WITH KNEE OSTEOARTHRITIS. ANNALS OF THE RHEUMATIC DISEASES. 2012 Jun: 473-474
  6. Rasmussen JV, Olsen BS, Fevang BT, Furnes O, Skytta ET, Rahme H et al. A Review Of National Shoulder And Elbow Joint Replacement Registries. J Shoulder Elbow Surg. 2012 Jun. doi: 10.1016/j.jse.2012.03.004
  7. Judge A, Arden NK, Cooper C, Kassim Javaid M, Carr AJ, Field RE et al. Predictors of outcomes of total knee replacement surgery. Rheumatology (Oxford). 2012 Apr 24. [Epub ahead of print]
  8. Fary C, Thomas GE, Taylor A, Beard D, Carr A, Glyn-Jones S. [Adverse Reactions Of Metal/Metal Hip Prostheses - Diagnosis And Examination]. Praxis (Bern 1994). 2012 Apr; 9(101): 593-599. doi: 10.1024/1661-8157/a000940
  9. Carr AJ, Robertsson O, Graves S, Price AJ, Arden NK, Judge A et al. Knee replacement. Lancet. 2012 Mar 5. [Epub ahead of print]
  10. Pollard TC, Batra RN, Judge A, Watkins B, McNally EG, Gill HS et al. Genetic predisposition to the presence and 5-year clinical progression of hip osteoarthritis. Osteoarthritis Cartilage. 2012 Feb 14. [Epub ahead of print]
  11. Chaudhury S, Carr AJ. Lessons we can learn from gene expression patterns in rotator cuff tears and tendinopathies. J Shoulder Elbow Surg. 2012 Feb;21(2):191-9
  12. Hakimi O, Murphy R, Stachewicz U, Hislop S, Carr AJ. An Electrospun Polydioxanone Patch For The Localisation Of Biological Therapies During Tendon Repair. Eur Cell Mater. 2012: 344-357
  13. Qiu Y, Wang X, Zhang Y, Carr AJ, Zhu L, Xia Z et al. Development of a refined tenocyte differentiation culture technique for tendon tissue engineering. Cells Tissues Organs. 2012; 1(197): 27-36
  14. Fary C, Thomas GER, Taylor A, Beard D, Carr A, Glyn-Jones S. Diagnosing And Investigating Adverse Reactions In Metal On Metal Hip Implants | Unerwünschte Reaktionen Bei Metall/Metall-Hüftendoprothesen - Diagnostik Und Untersuchung. Praxis. 2012; 9(101): 593-599
  15. Esapa CT, Hough TA, Testori S, Head RA, Crane EA, Chan CPS et al. A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to a Col2a1 mutation. Journal of Bone and Mineral Research. 2012; 2(27): 413-428
  16. Esapa CT, Head RA, Jeyabalan J, Evans H, Hough TA, Cheeseman MT et al. A Mouse With An N-Ethyl-N-Nitrosourea (Enu) Induced Trp589Arg Galnt3 Mutation Represents A Model For Hyperphosphataemic Familial Tumoural Calcinosis. PLoS One. 2012; 8(7): e43205. doi: 10.1371/journal.pone.0043205
  17. Rangan A, Brealey S, Carr A. Orthopaedic trial networks. Journal of Bone and Joint Surgery - Series A. 2012; SUPPL. 1(94): 97-100
  18. Cook JA, Ramsay CR, Carr AJ, Rees JL. A Questionnaire Elicitation Of Surgeons' Belief About Learning Within A Surgical Trial. PLoS One. 2012; 11(7): e49178. doi: 10.1371/journal.pone.0049178
  19. Liang M, Cornell HR, Zargar Baboldashti N, Thompson MS, Carr AJ, Hulley PA. Regulation of hypoxia-induced cell death in human tenocytes. Adv Orthop. 2012: 984950. doi: 10.1155/2012/984950
  20. Dawson J, Doll H, Boller I, Fitzpatrick R, Little C, Rees J et al. Specificity and responsiveness of patient reported and clinician rated outcome measures in the context of elbow surgery, comparing patients with and without rheumatoid arthritis. Revue de Chirurgie Orthopedique et Traumatologique. 2012; 6(98): 584-585
  21. Dawson J, Doll H, Boller I, Fitzpatrick R, Little C, Rees J et al. Specificity and responsiveness of patient-reported and clinician-rated outcome measures in the context of elbow surgery, comparing patients with and without rheumatoid arthritis. Orthopaedics and Traumatology: Surgery and Research. 2012; 6(98): 652-658

2011

  1. Judge A, Arden NK, Price A, Glyn-Jones S, Beard D, Carr AJ et al. Assessing patients for joint replacement: Can pre-operative Oxford hip and knee scores be used to predict patient satisfaction following joint replacement surgery and to guide patient selection?. J Bone Joint Surg Br. 2011 Dec;93(12):1660-4
  2. Prieto-Alhambra D, Javaid MK, Judge A, Murray D, Carr A, Cooper C et al. Association between bisphosphonate use and implant survival after primary total arthroplasty of the knee or hip: population based retrospective cohort study. BMJ. 2011 Dec 6;343:d7222. doi: 10.1136/bmj.d7222
  3. Tilley JM, Chaudhury S, Hakimi O, Carr AJ, Czernuszka JT. Tenocyte proliferation on collagen scaffolds protects against degradation and improves scaffold properties. J Mater Sci Mater Med. 2011 Dec 24. [Epub ahead of print]
  4. Chaudhury S, Holland C, Porter D, Tirlapur UK, Vollrath F, Carr AJ. Torn human rotator cuff tendons have reduced collagen thermal properties on differential scanning calorimetry. J Orthop Res. 2011 Dec;29(12):1938-43. doi: 10.1002/jor.21450. Epub 2011 May 11
  5. Fary C, Thomas GE, Taylor A, Beard D, Carr A, Glyn-Jones S. Diagnosing and investigating adverse reactions in metal on metal hip implants. BMJ. 2011 Nov 29;343:d7441. doi: 10.1136/bmj.d7441. No abstract available
  6. Hakimi O, Chaudhury S, Murphy R, Carr A. Differential growth on sutures of tendon cells derived from torn human rotator cuff. J Biomed Mater Res B Appl Biomater. 2011 Nov 28. doi: 10.1002/jbm.b.31993
  7. Fary C, Rhys GE, Taylor A, Beard D, Carr A, Glyn-Jones S. Practice Pointer Diagnosing And Investigating Adverse Reactions In Metal On Metal Hip Implants. BRITISH MEDICAL JOURNAL. 2011 Nov. doi: 10.1136/bmj.d7441
  8. Wang X, Qiu Y, Triffitt J, Carr A, Xia Z, Sabokbar A. Proliferation and differentiation of human tenocytes in response to platelet rich plasma: An in vitro and in vivo study. J Orthop Res. 2011 Nov 18. doi: 10.1002/jor.22016. [Epub ahead of print]
  9. Chaudhury S, Holland C, Thompson MS, Vollrath F, Carr AJ. Tensile and shear mechanical properties of rotator cuff repair patches. J Shoulder Elbow Surg. 2011 Nov 12. [Epub ahead of print]
  10. Day-Williams AG, Southam L, Panoutsopoulou K, Rayner NW, Esko T, Estrada K et al. A variant in MCF2L is associated with osteoarthritis. Am J Hum Genet. 2011 Sep 9;89(3):446-50. doi: 10.1016/j.ajhg.2011.08.001. Epub 2011 Aug 25
  11. Nicholls AS, Kiran A, Pollard TC, Hart D, Arden CP, Spector T et al. The association between hip morphology parameters and 19-year risk of end-stage osteoarthritis in the hip: A nested case-control study. Arthritis Rheum. 2011 Jul 7. doi: 10.1002/art.30523. [Epub ahead of print]
  12. Tilley JM, Carr AJ, Czernuszka JT. Atomic Force Microscopy of bulk tendon samples: Affect of location and fixation on tissue ultrastructure. MICRON. 2011 Jul;42(5):531-5. Epub 2011 Jan 6
  13. Nicholls AS, Kiran A, Javaid MK, Hart DJ, Spector TD, Carr AJ et al. Change in body mass index during middle age affects risk of total knee arthoplasty due to osteoarthritis: A 19-year prospective study of 1003 women. Knee. 2011 Jul 20. [Epub ahead of print]
  14. Chaudhury S, Holland C, Vollrath F, Carr AJ. Comparing normal and torn rotator cuff tendons using dynamic shear analysis. J Bone Joint Surg Br. 2011 Jul;93(7):942-8
  15. Rout R, McDonnell S, Benson R, Athanasou N, Carr A, Doll H et al. The histological features of Anteromedial Gonarthrosis - The comparison of two grading systems in a human phenotype of osteoarthritis. KNEE. 2011 Jun;18(3):172-6. Epub 2010 May 31
  16. Wang X, Qiu Y, Carr AJ, Triffitt JT, Sabokbar A, Xia Z. Improved human tenocyte proliferation and differentiation in vitro by optimized silk degumming. Biomed Mater. 2011 Jun;6(3):035010. Epub 2011 May 10
  17. Dawson J, Fitzpatrick R, Carr AJ, Churchman D. Assessing The Outcome Of Shoulder Surgery: Development, Validation And Responsiveness Of The Patient-Reported Oxford Shoulder Score (Oss). VALUE IN HEALTH. 2011 May; 3(14): A90
  18. Carr A. Combined treatment with corticosteroid injection plus exercise and manual therapy was similar to exercise and manual therapy alone for shoulder pain at 12 weeks. J Bone Joint Surg Am. 2011 May 18;93(10):971. No abstract available
  19. Brown CP, Jayadev C, Glyn-Jones S, Carr AJ, Murray DW, Price AJ et al. Characterization of early stage cartilage degradation using diffuse reflectance near infrared spectroscopy. PHYS MED BIOL. 2011 Apr 7;56(7):2299-307. Epub 2011 Mar 16
  20. Gwilym SE, Oag HC, Tracey I, Carr AJ. Evidence that central sensitisation is present in patients with shoulder impingement syndrome and influences the outcome after surgery. J Bone Joint Surg Br. 2011 Apr;93(4):498-502
  21. Chaudhury S, Dicko C, Burgess M, Vollrath F, Carr AJ. Fourier transform infrared spectroscopic analysis of normal and torn rotator-cuff tendons. J Bone Joint Surg Br. 2011 Mar;93(3):370-7
  22. Poulsen RC, Carr AJ, Hulley PA. Protection against Glucocorticoid-Induced Damage in Human Tenocytes by Modulation of ERK, Akt, and Forkhead Signaling. ENDOCRINOLOGY. 2011 Feb;152(2):503-14. Epub 2011 Jan 5
  23. Arden NK, Kiran A, Judge A, Biant LC, Javaid MK, Murray DW et al. What is a good patient reported outcome after total hip replacement?. OSTEOARTHR CARTILAGE. 2011 Feb;19(2):155-62. Epub 2010 Oct 15
  24. Dodd AW, Rodriguez-Fontenla C, Calaza M, Carr A, Gomez-Reino JJ, Tsezou A et al. Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus. OSTEOARTHR CARTILAGE. 2011 Jan 28. [Epub ahead of print]
  25. Southam L, Panoutsopoulou K, Rayner NW, Chapman K, Durrant C, Ferreira T et al. The effect of genome-wide association scan quality control on imputation outcome for common variants. EUR J HUM GENET. 2011 May;19(5):610-614. Epub 2011 Jan 26
  26. Meulenbelt I, Bos SD, Chapman K, van der Breggen R, Houwing-Duistermaat JJ, Kremer D et al. Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility. Ann Rheum Dis. 2011 Jan;70(1):164-7. Epub 2010 Aug 19
  27. Murphy R, Carr A. Shoulder pain. AM FAM PHYSICIAN. 2011 Jan 15;83(2):137. No abstract available
  28. Hakimi O, Vollrath F, Carr AJ. Evaluation of Silk as a Scaffold for Musculoskeletal Regeneration: the Path from the Laboratory to Clinical Trials. In: Comprehensive Biotechnology (Second Edition), Academic Press (2011), Burlington, pp 341-351

2010

  1. Panoutsopoulou K, Southam L, Elliott KS, Wrayner N, Zhai G, Beazley C et al. Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study. ANN RHEUM DIS. 2010 Dec 21. [Epub ahead of print]
  2. Kerkhof HJ, Meulenbelt I, Carr A, Gonzalez A, Hart D, Hofman A et al. Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis. BMC MED GENET. 2010 Nov 16;11(1):164. [Epub ahead of print]
  3. Evangelou E, Valdes AM, Kerkhof HJ, Styrkarsdottir U, Zhu Y, Meulenbelt I et al. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. ANN RHEUM DIS. 2010 Nov 10. [Epub ahead of print]
  4. Kerkhof HJ, Meulenbelt I, Akune T, Arden NK, Aromaa A, Bierma-Zeinstra SM et al. Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. OSTEOARTHR CARTILAGE. 2010 Nov 6. [Epub ahead of print]
  5. Gwilym SE, Filippini N, Douaud G, Carr AJ, Tracey I. Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study. ARTHRITIS RHEUM-US. 2010 Oct;62(10):2930-40
  6. Dawson J, Rogers K, Doll H, Fitzpatrick R, Cooper C, Carr A. Using Patient-Reported Outcome Measures (PROMs) Routinely: An Example in the Context of Elective Shoulder Surgery. The Open Epidemiology Journal. 2010 Oct; 1(4): 42-52. doi: 10.2174/18742971010030100042
  7. Rees JL, Dawson J, Hand GC, Cooper CD, Judge A, Price AJ et al. The use of patient-reported outcome measures and patient satisfaction ratings to assess outcome in hemiarthroplasty of the shoulder. J Bone Joint Surg Br. 2010 Aug;92(8):1107-11
  8. Riancho JA, Garca-Ibarbia C, Gravani A, Raine EV, Rodríguez-Fontenla C, Soto-Hermida A et al. Common variations in estrogen-related genes are associated with severe large-joint osteoarthritis: a multicenter genetic and functional study. OSTEOARTHR CARTILAGE. 2010 Jul;18(7):927-33. Epub 2010 Apr 22
  9. Murphy RJ, Carr AJ. Shoulder pain. Clin Evid (Online). 2010 Jul 22;2010. pii: 1107
  10. Dawson J, Fitzpatrick R, Doll H, Carr AJ, Churchman D. Assessing The Outcome Of Elbow Surgery: Development, Validation And Responsiveness Of The Patient-Reported Oxford Elbow Score (Oes). VALUE HEALTH. 2010 May; 3(13): A102
  11. Dawson J, Doll H, Boller I, Fitzpatrick R, Little C, Rees J et al. Factors associated with satisfaction in patients undergoing elbow surgery: A prospective study. J SHOULDER ELB SURG. 2010 May 6. [Epub ahead of print]
  12. Pollard TCB, McNally EG, Wilson DC, Wilson DR, Madler B, Watson M et al. Localized Cartilage Assessment with Three-Dimensional dGEMRIC in Asymptomatic Hips With Normal and Cam Morphology. J BONE JOINT SURG AM. 2010 Nov 3;92(15):2557-69
  13. Chaudhury S, Gwilym SE, Moser J, Carr AJ. Surgical options for patients with shoulder pain. NAT REV RHEUMATOL. 2010 Apr;6(4):217-26
  14. Benson RT, McDonnell SM, Knowles HJ, Rees JL, Carr AJ, Hulley PA. Tendinopathy and tears of the rotator cuff are associated with hypoxia and apoptosis. J Bone Joint Surg Br. 2010 Mar;92(3):448-53
  15. Price AJ, Longino D, Rees J, Rout R, Pandit H, Javaid K et al. Are pain and function better measures of outcome than revision rates after TKR in the younger patient?. KNEE. 2010 Jun;17(3):196-9. Epub 2010 Feb 4
  16. Pollard TC, Villar RN, Norton MR, Fern ED, Williams MR, Simpson DJ et al. Femoroacetabular impingement and classification of the cam deformity: the reference interval in normal hips. Acta Orthop. 2010 Feb;81(1):134-41
  17. Pollard TC, Villar RN, Norton MR, Fern ED, Williams MR, Murray DW et al. Genetic influences in the aetiology of femoroacetabular impingement: a sibling study. J Bone Joint Surg Br. 2010 Feb;92(2):209-16
  18. Kerkhof HJ, Lories RJ, Meulenbelt I, Jonsdottir I, Valdes AM, Arp P et al. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. ARTHRITIS RHEUM-US. 2010 Feb;62(2):499-510
  19. Moxley G, Meulenbelt I, Chapman K, van Diujn CM, Slagboom PE, Neale MC et al. Interleukin-1 region meta-analysis with osteoarthritis phenotypes. OSTEOARTHR CARTILAGE. 2010 Feb;18(2):200-7. Epub 2009 Sep 1
  20. Dawson J, Doll H, Fitzpatrick R, Jenkinson C, Carr AJ. The routine use of patient reported outcome measures in healthcare settings. BRIT MED J. 2010 Jan 18;340:c186. doi: 10.1136/bmj.c186
  21. Carr A, Gwilym S. Orthopaedic surgery: Current trends and recent innovations. Key Topics in Surgical Research and Methodology. 2010: 913-922. doi: 10.1007/978-3-540-71915-1_70