Nigel Arden

Nigel Arden

Professor Nigel Arden

MBBS, FRCP, MSc, MD

Professor of Rheumatology
Director of Musculoskeletal Epidemiology
Director of Oxford Musculoskeletal BioBank
Deputy Director of Oxford Biomedical Research Unit

Email: nigel.arden@ndorms.ox.ac.uk

Professor Arden trained at St Thomas's Hospital, London, where he also completed four years of research into the genetics of osteoporosis. During this time, he gained an MSc in Epidemiology and an MD.

He moved to the South Coast in 1996 and in 1998 spent six months as Visiting Professor in Epidemiology at the University of San Francisco.

In February 2000 he commenced his post as Consultant Rheumatologist at Southampton General Hospital, and Senior Lecturer in Rheumatology at the University of Southampton. He is based at the Botnar Research Centre, where he continues his research into osteoarthritis and osteoporosis. He currently is a Member of WHO/International Osteoporosis Foundation Committee for e-learning project and the National Osteoporosis Society Scientific Advisory Board; he is an International Osteoporosis Foundation Scientific Ambassador and sits on the EULAR (European League Against Rheumatism) Osteoarthritis Guideline Committee and OARSI (Osteoarthritis Research Society International) Guidelines Committee.

Research Interests:

  • The epidemiology and pathophysiology of osteoarthritis
  • The epidemiology and pathophysiology of osteoporosis
  • The role of vitamin D in musculoskeletal health
  • Clinical trials in common musculoskeletal conditions

Publications

View all publications (the list below shows the past five years). Arranged by year. Sorted by date of publication. Sort by title? Where possible, links point to PubMed. Click icon to switch to Europe PubMed Central UK PubMed Central icon

2015

  1. Arden N, Richette P, Cooper C, Bruyère O, Abadie E, Branco J et al. Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Biomarkers and Frailty. Drugs & aging. 2015 Jul; 7(32): 525-535. doi: 10.1007/s40266-015-0276-7
  2. Hawley S, Javaid MK, Rubin KH, Judge A, Arden NK, Vestergaard P et al. Incidence and Predictors of Multiple Fractures Despite High Adherence to Oral Bisphosphonates: A Binational Population-Based Cohort Study. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2015 Jul. doi: 10.1002/jbmr.2595
  3. Kluzek S, Newton JL, Arden NK. Is osteoarthritis a metabolic disorder?. British medical bulletin. 2015 Jul. doi: 10.1093/bmb/ldv028
  4. Kluzek S, Arden NK, Newton J. Adipokines as potential prognostic biomarkers in patients with acute knee injury. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2015 May: 1-7
  5. Hunter DJ, Arden N, Cicuttini F, Crema MD, Dardzinski B, Duryea J et al. OARSI Clinical Trials Recommendations: Hand imaging in clinical trials in osteoarthritis. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2015 May; 5(23): 732-746. doi: 10.1016/j.joca.2015.03.003
  6. Kingsbury SR, Tharmanathan P, Arden NK, Batley M, Birrell F, Cocks K et al. Pain reduction with oral methotrexate in knee osteoarthritis, a pragmatic phase iii trial of treatment effectiveness (PROMOTE): study protocol for a randomized controlled trial. TRIALS. 2015 Mar. doi: 10.1186/s13063-015-0602-8
  7. Bruyère O, Cooper C, Arden N, Branco J, Brandi ML, Herrero-Beaumont G et al. Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Epidemiology and Phenotype of Osteoarthritis. Drugs and Aging. 2015 Feb. doi: 10.1007/s40266-015-0243-3
  8. Hardcastle SA, Dieppe P, Gregson CL, Arden NK, Spector TD, Hart DJ et al. Individuals with high bone mass have an increased prevalence of radiographic knee osteoarthritis. Bone. 2015 Feb: 171-179. doi: 10.1016/j.bone.2014.10.015
  9. Colebatch-Bourn AN, Conaghan PG, Arden NK, Cooper C, Dougados M, Edwards CJ. Raising the quality of rheumatology management recommendations: lessons from the EULAR process 10 years after provision of standard operating procedures. Rheumatology (Oxford, England). 2015 Feb
  10. Kiran A, Bottomley N, Biant LC, Javaid MK, Carr AJ, Cooper C et al. Variations In Good Patient Reported Outcomes After Total Knee Arthroplasty. The Journal of arthroplasty. 2015 Feb. doi: 10.1016/j.arth.2015.02.039
  11. Mukherjee S, Culliford D, Arden N, Edwards C. What is the risk of having a total hip or knee replacement for patients with lupus?. LUPUS. 2015 Feb; 2(24): 198-202. doi: 10.1177/0961203314547894
  12. Hochberg MC, Martel-Pelletier J, Monfort J, Möller I, Castillo JR, Arden N et al. Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib. Annals of the rheumatic diseases. 2015 Jan. doi: 10.1136/annrheumdis-2014-206792
  13. Mcalindon TEM, Bannuru RR, Sullivan MC, Arden NK, Bérenbaum F, Bierma-Zeinstra SMA et al. Corrigendum to \'2014 OARSI Guidelines for the Non-Surgical Management of Knee Osteoarthritis\' [Osteoarthritis and Cartilage 22(2014) 363-388]. Osteoarthritis and Cartilage. 2015 Jan. doi: 10.1016/j.joca.2015.02.014
  14. McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM et al. Corrigendum to \'2014 OARSI Guidelines for the Non-Surgical Management of Knee Osteoarthritis\' [Osteoarthritis and Cartilage 22(2014) 363-388]. Osteoarthritis and Cartilage. 2015 Jan; 6(23): 1026-1034. doi: 10.1016/j.joca.2015.02.014
  15. Culliford D, Maskell J, Judge A, Cooper C, Prieto-Alhambra D, Arden NK. Future Projections Of Total Hip And Knee Arthroplasty In The Uk: Results From The Uk Clinical Practice Research Datalink. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2015 Jan. doi: 10.1016/j.joca.2014.12.022
  16. Robson JC, Kiran A, Maskell J, Hutchings A, Arden N, Dasgupta B et al. The relative risk of aortic aneurysm in patients with giant cell arteritis compared with the general population of the UK. ANNALS OF THE RHEUMATIC DISEASES. 2015 Jan; 1(74): 129-135. doi: 10.1136/annrheumdis-2013-204113

2014

  1. Martinez-Laguna D, Tebe C, Javaid MK, Nogues X, Arden NK, Cooper C et al. Incident type 2 diabetes and hip fracture risk: a population-based matched cohort study. Osteoporosis international. 2014 Dec
  2. Kerkhof HJ, Bierma-Zeinstra SM, Arden NK, Metrustry S, Castano-Betancourt M, Hart DJ et al. Prediction model for knee osteoarthritis incidence, including clinical, genetic and biochemical risk factors. Annals of the rheumatic diseases. 2014 Dec; 12(73): 2116-2121. doi: 10.1136/annrheumdis-2013-203620
  3. Prieto-Alhambra D, Muñoz-Ortego J, De Vries F, Vosse D, Arden NK, Bowness P et al. Ankylosing spondylitis confers substantially increased risk of clinical spine fractures: a nationwide case-control study. Osteoporosis international. 2014 Oct. doi: 10.1007/s00198-014-2939-3
  4. Hochberg M, Martel-Pelletier J, Monfort J, Moller I, Ramon Castillo J, Arden NK et al. Combined Chondroitin Sulfate and Glucosamine Is Comparable to Celecoxib for Painful Knee Osteoarthritis. Results from a Multicenter, Randomized, Double-Blind, PHASE IV NON-Inferiority TRIAL. ARTHRITIS & RHEUMATOLOGY. 2014 Oct: S971
  5. Fina-Aviles F, Medina-Peralta M, Mendez-Boo L, Hermosilla E, Elorza JM, Garcia-Gil M et al. The descriptive epidemiology of rheumatoid arthritis in Catalonia: a retrospective study using routinely collected data. Clinical rheumatology. 2014 Oct. doi: 10.1007/s10067-014-2801-1
  6. Luqmani R, Morsley K, Miller A, Edwards CJ, Javaid MK, Prieto-Alhambra D et al. Diagnostic Accuracy and Associated Costs of Rheumatoid Factor Testing in Primary Care: A Population-Based Cohort Study in Spain. ARTHRITIS & RHEUMATOLOGY. 2014 Oct: S157-S158
  7. Wilson N, Sanchez-Riera L, Morros R, Diez-Perez A, Javaid MK, Cooper C et al. Drug utilization in patients with OA: a population-based study. Rheumatology (Oxford, England). 2014 Oct. doi: 10.1093/rheumatology/keu403
  8. Nelson AE, Stiller JL, Shi XA, Leyland KM, Renner JB, Schwartz TA et al. Measures of Hip Morphology Are Related to Development of Incident Radiographic Hip Osteoarthritis over 6 to 13 Year Follow-up: The Johnston County Osteoarthritis Project. ARTHRITIS & RHEUMATOLOGY. 2014 Oct: S84
  9. Castillo JR, Hochberg MC, Martel-Pelletier J, Monfort J, Moeller I, Arden N et al. MULTICENTRIC OSTEOARTHRITIS INTERVENTION STUDY WITH SYSADOA (MOVES): EFFECTS OF COMBINED GLUCOSAMINE HYDROCHLORIDE AND CHONDROITIN SULFATE VS. CELECOXIB FOR PAINFUL KNEE OSTEOARTHRITIS. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2014 Oct: 12
  10. Agricola R, Waarsing JH, Thomas GE, Carr AJ, Reijman M, Bierma-Zeinstra SM et al. Response to letter to editor: "Cam impingement: defining the presence of a cam deformity by the alpha angle Data from the CHECK cohort an Chingford cohort". Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2014 Oct. doi: 10.1016/j.joca.2014.09.022
  11. Ramos YF, Metrustry S, Arden N, Bay-Jensen AC, Beekman M, de Craen AJ et al. Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance. Journal of medical genetics. 2014 Sep; 9(51): 596-604. doi: 10.1136/jmedgenet-2014-102478
  12. Hochberg MC, Martel-Pelletier J, Monfort J, Moeller I, Castillo J-R, Arden N et al. MULTICENTRIC OSTEOARTHRITIS INTERVENTION STUDY WITH SYSADOA (MOVES): EFFECTS OF COMBINED GLUCOSAMINE HYDROCHLORIDE AND CHONDROITIN SULFATE VS CELECOXIB FOR PAINFUL KNEE OSTEOARTHRITIS. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2014 Sep: 25
  13. Hardcastle SA, Dieppe P, Gregson CL, Arden NK, Spector TD, Hart DJ et al. Osteophytes, enthesophytes, and high bone mass: a bone-forming triad with potential relevance in osteoarthritis. Arthritis & rheumatology (Hoboken, N.J.). 2014 Sep; 9(66): 2429-2439. doi: 10.1002/art.38729
  14. Conaghan PG, Peloso PM, Everett SV, Rajagopalan S, Black CM, Mavros P et al. Inadequate pain relief and large functional loss among patients with knee osteoarthritis: evidence from a prospective multinational longitudinal study of osteoarthritis real-world therapies. Rheumatology (Oxford, England). 2014 Aug. doi: 10.1093/rheumatology/keu332
  15. Kynaston-Pearson F, Ashmore AM, Malak TT, Rombach I, Taylor A, Beard D et al. Primary hip replacement prostheses and their evidence base: systematic review of literature. British journal of sports medicine. 2014 Aug; 15(48): 1198. doi: 10.1136/bjsports-2014-f6956rep
  16. Gay A, Culliford D, Leyland K, Arden NK, Bowen CJ. Associations between body mass index and foot joint pain in middle-aged and older women: a longitudinal population-based cohort study. Arthritis care & research. 2014 Jul. doi: 10.1002/acr.22408
  17. Hinsley H, Nicholls A, Daines M, Wallace G, Arden N, Carr A. Classification of rotator cuff tendinopathy using high definition ultrasound. Muscles, ligaments and tendons journal. 2014 Jul; 3(4): 391-397
  18. Prieto-Alhambra D, Lalmohamed A, Abrahamsen B, Arden NK, de Boer A, Vestergaard P et al. Oral bisphosphonate use and total knee/hip implant survival: validation of results in an external population-based cohort. Arthritis & rheumatology (Hoboken, N.J.). 2014 Jul. doi: 10.1002/art.38789
  19. Thomas GE, Palmer AJ, Batra RN, Kiran A, Hart D, Spector T et al. Subclinical deformities of the hip are significant predictors of radiographic osteoarthritis and joint replacement in women. A 20 year longitudinal cohort study. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2014 Jul
  20. Vimaleswaran KS, Cavadino A, Berry DJ, Jorde R, Dieffenbach AK, Lu C et al. Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. The lancet. Diabetes & endocrinology. 2014 Jun
  21. Hooper L, Bowen CJ, Gates L, Culliford D, Arden NK, Edwards CJ. Comparative distribution of ultrasound-detectable forefoot bursae in patients with osteoarthritis and rheumatoid arthritis. Arthritis Care and Research. 2014 Jun; 6(66): 869-877. doi: 10.1002/acr.22217
  22. Kiran A, Hunter DJ, Judge A, Field RE, Javaid MK, Cooper C et al. A Novel Methodological Approach for Measuring Symptomatic Change Following Total Joint Arthroplasty. The Journal of arthroplasty. 2014 Jun. doi: 10.1016/j.arth.2014.06.008
  23. Hiligsmann M, Cooper C, Guillemin F, Hochberg MC, Tugwell P, Arden N et al. A reference case for economic evaluations in osteoarthritis: An expert consensus article from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Seminars in arthritis and rheumatism. 2014 Jun. doi: 10.1016/j.semarthrit.2014.06.005
  24. Cherry L, King L, Thomas M, Roemer F, Culliford D, Bowen CJ et al. The reliability of a novel magnetic resonance imaging-based tool for the evaluation of forefoot bursae in patients with rheumatoid arthritis: the FFB score. Rheumatology (Oxford). 2014 Jun. doi: 10.1093/rheumatology/keu232
  25. Wallace G, Judge A, Alhambra DP, de Vries F, Arden NK, Cooper C. The effect of body mass index on the risk of post-operative complications during the six months following total hip replacement or total knee replacement surgery. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2014 May. doi: 10.1016/j.joca.2014.04.013
  26. Styrkarsdottir U, Thorleifsson G, Helgadottir HT, Bomer N, Metrustry S, Bierma-Zeinstra S et al. Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31. Nature genetics. 2014 May; 5(46): 498-502. doi: 10.1038/ng.2957
  27. Rodriguez-Fontenla C, Calaza M, Gonzalez A, Evangelou E, Ntzani EE, Ioannidis JPA et al. Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies. Arthritis and Rheumatology. 2014 Apr; 4(66): 940-949. doi: 10.1002/art.38300
  28. Pinedo-Villanueva R, Turner D, Raftery JP, Cooper C, Arden NK, Grp C. COST-EFFECTIVENESS OF TOTAL HIP REPLACEMENTS: A COMPREHENSIVE MODEL. OSTEOPOROSIS INTERNATIONAL. 2014 Apr: S286
  29. Kluzek S, Bay-Jensen A-C, Spector T, Hart D, Leyland K, Sanchez-Santos M et al. HIGHER SERUM LEVELS OF CARTILAGE OLIGOMERIC MATRIX PROTEIN (COMP) ARE ASSOCIATED WITH SELF-REPORTED KNEE PAIN. OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S74
  30. Rannou F, Peloso PM, Rajagopalan S, Mavros P, Everett SV, Arden N et al. LONGITUDINAL ASSESSMENT OF PAIN IN PATIENTS WITH KNEE OSTEOARTHRITIS (OA): USING DATA FROM THE STUDY OF REAL WORLD THERAPIES (SORT). OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S224
  31. Leyland KM, Sanchez-Santos MT, Muraki S, Judge A, Spector TD, Hart DJ et al. MANUAL LABOR OCCUPATIONS INCREASE THE SHORT-TERM INCIDENCE OF KNEE OSTEOARTHRITIS IN JAPANESE, BUT NOT CAUCASIAN SUBJECTS. OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S398
  32. Hardcastle SA, Dieppe P, Gregson CL, Arden NK, Spector TD, Hart DJ et al. OSTEOPHYTES, ENTHESOPHYTES AND INCREASED BONE MASS TOGETHER MAY HELP TO DEFINE A "BONE-FORMING" SUB-TYPE OF OSTEOARTHRITIS. OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S352
  33. van Middelkoop M, Arden N, Atchia I, Birrell F, Chao J, Lambert RG et al. THE OA TRIAL BANK: META-ANALYSIS OF INDIVIDUAL PATIENT DATA SHOW THAT PATIENTS WITH SEVERE PAIN OR WITH INFLAMMATORY SIGNS DETECTED BY ULTRASOUND ESPECIALLY BENEFIT FROM INTRA-ARTICULAR GLUCOCORTICOIDS FOR KNEE OR HIP OA. OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S474-S475
  34. Pinedo-Villanueva R, Turner D, Raftery JP, Cooper C, Arden NK. OUTCOMES AFTER TOTAL HIP REPLACEMENT. OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S214
  35. Judge A, Batra RN, Murray D, Dieppe PA, Sanchez-Santos MT, Thomas G et al. PATIENT REPORTED OUTCOMES FOLLOWING PRIMARY HIP REPLACEMENT SURGERY: DEVELOPMENT AND INTERNAL VALIDATION OF A PROGNOSTIC TOOL. OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S209
  36. Soni A, Batra R, Leyland K, Gwylim S, Spector T, Hart D et al. PRAGMATIC APPROACH TO QUANTITATIVE SENSORY TESTING IN KNEE OSTEOARTHRITIS: MEASURES OF MECHANICAL PAIN SENSITIVITY PREDICT CONCORDANT PAIN AND STRUCTURAL STATUS. OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S418
  37. Soni A, Gwylim S, Arden N, Tracey I, Price A, Javaid M. PRE-OPERATIVE EXPERIMENTAL THERMAL SENSITIVITY PREDICTS OXFORD KNEE SCORE 1-YEAR POST-OPERATIVELY: A PRELIMINARY STUDY. OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S414-S415
  38. Hardcastle SA, Dieppe P, Gregson CL, Hunter D, Thomas G, Arden NK et al. THE PREVALENCE OF RADIOGRAPHIC HIP OSTEOARTHRITIS IS INCREASED IN HIGH BONE MASS; A CASE-CONTROL STUDY. OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S343
  39. Pinedo-Villanueva R, Turner D, Raftery JP, Cooper C, Arden NK, Grp C. PRIMARY CARE COSTS ATTRIBUTABLE TO OSTEOARTHRITIS BEFORE TOTAL HIP REPLACEMENT. OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S210-S211
  40. Toner A, Wallace G, Rowe J, Garden S, Alhambra DP, Arden NK. THE RELATIONSHIP BETWEEN PRE-OPERATIVE \'TIMED GET UP AND GO\' AND LENGTH OF STAY IN PRIMARY ELECTIVE HIP AND KNEE ARTHROPLASTY PATIENTS. OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S380-S381
  41. Leyland KM, Sanchez-Santos MT, Kluzek S, Prieto-Alhambra D, Spector TD, Hart DJ et al. SUBJECTS WITH SELF-REPORTED BASELINE INJURY HAVE AN INCREASED RISK OF SYMPTOMATIC RADIOGRAPHIC KNEE OSTEOARTHRITIS OVER TWENTY-YEARS. OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S385
  42. Culliford DJ, Judge A, Prieto-Alhambra D, Cooper C, Arden NK. UK TEMPORAL TRENDS FOR TIME FROM DIAGNOSIS OF HIP/KNEE OSTEOARTHRITIS TO JOINT REPLACEMENT. OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S213
  43. Muñoz-Ortego J, Vestergaard P, Rubio JB, Wordsworth P, Judge A, Javaid MK et al. Ankylosing Spondylitis is Associated with an Increased Risk of Vertebral and Non-Vertebral Clinical Fractures: A Population-Based Cohort Study. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2014 Mar. doi: 10.1002/jbmr.2217
  44. McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis and Cartilage. 2014 Mar; 3(22): 363-388. doi: 10.1016/j.joca.2014.01.003
  45. Prieto-Alhambra D, Premaor MO, Avilés FF, Castro AS, Javaid MK, Nogués X et al. Relationship Between Mortality and BMI After Fracture: A Population-Based Study of Men and Women Aged ≥40 Years. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2014 Feb. doi: 10.1002/jbmr.2209
  46. Judge A, Batra RN, Thomas G, Beard D, Javaid MK, Murray D et al. Body mass index is not a clinically meaningful predictor of patient reported outcomes of primary hip replacement surgery: prospective cohort study. Osteoarthritis Cartilage. 2014 Jan. doi: 10.1016/j.joca.2013.12.018
  47. Prieto-Alhambra D, Javaid MK, Judge A, Maskell J, Cooper C, Arden NK. Hormone replacement therapy and mid-term implant survival following knee or hip arthroplasty for osteoarthritis: a population-based cohort study. Ann Rheum Dis. 2014 Jan. doi: 10.1136/annrheumdis-2013-204043
  48. Judge A, Murphy RJ, Maxwell R, Arden NK, Carr AJ. Temporal trends and geographical variation in the use of subacromial decompression and rotator cuff repair of the shoulder in England. Bone Joint J. 2014 Jan; 1(96): 70-74. doi: 10.1302/0301-620X.96B1.32556
  49. James SJ, Mirza SB, Culliford DJ, Taylor PA, Carr AJ, Arden NK. Baseline bone mineral density and boneturnover in pre-operative hip and knee arthroplasty patients. Bone Joint Res. 2014; 1(3): 14-19. doi: 10.1302/2046-3758.31.2000218
  50. Valdes AM, Hart D, Spector TD, Meulenbelt I, Slagboom EP, Chassaing E et al. Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis. Osteoarthritis and Cartilage. 2014. doi: 10.1016/j.joca.2014.02.007
  51. Aref-Eshghi E, Zhang Y, Hart D, Valdes AM, Furey A, Martin G et al. SMAD3 is associated with the total burden of radiographic osteoarthritis: the Chingford study. PloS one. 2014; 5(9): e97786. doi: 10.1371/journal.pone.0097786

2013

  1. Hiligsmann M, Bruyère O, Reginster J-Y, Cooper C, Arden N, Boers M et al. Health economics in the field of osteoarthritis: An Expert's consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Seminars in Arthritis and Rheumatism. 2013 Dec; 3(43): 303-313. doi: 10.1016/j.semarthrit.2013.07.003
  2. Kynaston-Pearson F, Ashmore AM, Malak TT, Rombach I, Taylor A, Beard D et al. Primary hip replacement prostheses and their evidence base: Systematic review of literature. BMJ (Online). 2013 Dec. doi: 10.1136/bmj.f6956
  3. Judge A, Arden NK. Decision making in knee arthroplasty. Rheumatology (Oxford). 2013 Oct. doi: 10.1093/rheumatology/ket339
  4. Arden NK, Akermark C, Andersson M, Todman MG, Altman RD. A randomized saline-controlled trial of NASHA hyaluronic acid for knee osteoarthritis. Curr Med Res Opin. 2013 Oct. doi: 10.1185/03007995.2013.855631
  5. Robson JC, Kiran A, Arden N, Luqmani RA, Maskell J, Culliford D et al. The relative risk of aortic aneurysm in patients with giant cell arteritis compared with the general population of the UK. Annals of the Rheumatic Diseases. 2013 Oct. doi: 10.1136/annrheumdis-2013-204113
  6. Beard D, Price A, Carr A, Arden N, Cooper C, Davies L et al. Total or Partial Knee Arthroplasty Trial - TOPKAT: Study protocol for a randomised controlled trial. Trials. 2013 Sep; 1(14). doi: 10.1186/1745-6215-14-292
  7. Panoutsopoulou K, Zeggini E, Metrustry S, Hart DJ, Spector TD, Valdes AM et al. The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: A mendelian randomisation study. Annals of the Rheumatic Diseases. 2013 Aug. doi: 10.1136/annrheumdis-2013-203772
  8. Evangelou E, Ntzani EE, Tsilidis KK, Ioannidis JPA, Metrustry S, Spector TD et al. A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip. Annals of the Rheumatic Diseases. 2013 Aug. doi: 10.1136/annrheumdis-2012-203114
  9. Bowen CJ, Hooper L, Edwards CJ, Arden NK. Using ultrasound to image the foot in rheumatoid arthritis: Current understanding, challenges and future scope. Imaging in Medicine. 2013 Aug; 4(5): 347-356. doi: 10.2217/iim.13.37
  10. Agricola R, Waarsing JH, Bierma-Zeinstra SMA, Arden NK, Carr AJ, Thomas GE et al. Cam impingement of the hip-a risk factor for hip osteoarthritis. Nature Reviews Rheumatology. 2013 Jul. doi: 10.1038/nrrheum.2013.114
  11. Neogi T, Soni A, Cooper C, Arden NK, Doherty SA, Zhang W et al. Contribution of the COMT Val158Met variant to symptomatic knee osteoarthritis. Annals of the Rheumatic Diseases. 2013 Jul. doi: 10.1136/annrheumdis-2013-203836
  12. Arden NK, Leyland K. Osteoarthritis year 2013 in review: Clinical. Osteoarthritis Cartilage. 2013 Jul. doi: 10.1016/j.joca.2013.06.021
  13. Boucas SB, Lennie KH, Dziedzic K, Arden N, Burridge J, Hammond A et al. DIFFERENCES BETWEEN SERVICE PROVIDERS AND USERS WHEN DEFINING FEASIBLE OPTIMAL NHS OCCUPATIONAL THERAPY TREATMENT FOR PATIENTS WITH THUMB BASE OA: RESULTS FROM A DELPHI STUDY. ANNALS OF THE RHEUMATIC DISEASES. 2013 Jun: 1083
  14. Prieto-Alhambra D, Judge A, Arden NK, Cooper C, Lyles KW, Javaid MK. Fracture prevention in patients with cognitive impairment presenting with a hip fracture: secondary analysis of data from the HORIZON Recurrent Fracture Trial. Osteoporos Int. 2013 Jun. doi: 10.1007/s00198-013-2420-8
  15. Prieto-Alhambra D, Judge A, Javaid MK, Cooper C, Diez-Perez A, Arden NK. Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints. Ann Rheum Dis. 2013 Jun. doi: 10.1136/annrheumdis-2013-203355
  16. Prieto-Alhambra D, Leyland K, Judge A, Javaid MK, Cooper C, Arden NK. THE INFLUENCE OF OVERWEIGHT/OBESITY ON THE RISK OF TOTAL KNEE ARTHROPLASTY AMONGST PATIENTS WITH NEWLY DIAGNOSED KNEE OSTEOARTHRITIS: A POPULATION-BASED COHORT STUDY. ANNALS OF THE RHEUMATIC DISEASES. 2013 Jun: 339-340
  17. Prieto-Alhambra D, Pagès-Castellà A, Wallace G, Javaid M, Judge A, Nogués X et al. Predictors of fracture while on treatment with oral bisphosphonates: A population-based cohort study. J Bone Miner Res. 2013 Jun. doi: 10.1002/jbmr.2011
  18. Soni A, Batra R, Gwilym S, Spector T, Hart D, Arden N et al. Neuropathic features of joint pain: A community-based study. Arthritis Rheum. 2013 Apr. doi: 10.1002/art.37962
  19. Robson J, Kiran A, Maskell J, Hutchings A, Arden N, Dasgupta B et al. The relative risk of aortic aneurysm in patients with giant cell arteritis compared with the general population of the UK. PRESSE MEDICALE. 2013 Apr; 4(42): 672-673. doi: 10.1016/j.lpm.2013.02.052
  20. Naidoo S, Bowen C, Redmond A, Arden N. Training the next generation of clinical researchers: Evaluation of a graduate podiatrist research internship in rheumatology. Journal of Foot and Ankle Research. 2013 Apr; 1(6). doi: 10.1186/1757-1146-6-15
  21. Javaid M, Arden N. Bone and osteoarthritis: What is the relationship?. Arthritis Rheum. 2013 Mar. doi: 10.1002/art.37924
  22. Kingsbury SR, Grainger A, Wakefield RJ, Conaghan PG, Tharmanathan P, Adamson J et al. Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis (HERO): Study protocol for a randomized controlled trial. Trials. 2013 Mar; 1(14). doi: 10.1186/1745-6215-14-64
  23. Palmer AJ, Thomas GE, Pollard TC, Rombach I, Taylor A, Arden N et al. The feasibility of performing a randomised controlled trial for femoroacetabular impingement surgery. Bone Joint Res. 2013 Feb; 2(2): 33-40. doi: 10.1302/2046-3758.22.2000137
  24. Williams DP, Price AJ, Beard DJ, Hadfield SG, Arden NK, Murray DW et al. The Effects Of Age On Patient-Reported Outcome Measures In Total Knee Replacements. Bone Joint J. 2013 Jan; 1(95-B): 38-44. doi: 10.1302/0301-620X.95B1.28061
  25. Blumenfeld O, Livshits G, Williams FMK, Hart DJ, Spector TD, Arden N. Association between cartilage and bone biomarkers and incidence of radiographic knee osteoarthritis (RKOA) in UK females: a prospective study. Osteoarthritis and Cartilage. 2013. doi: 10.1016/j.joca.2013.04.009
  26. Judge A, Arden NK, Batra RN, Thomas G, Beard D, Javaid MK et al. The association of patient characteristics and surgical variables on symptoms of pain and function over 5 years following primary hip-replacement surgery: a prospective cohort study. BMJ Open. 2013; 3(3). doi: 10.1136/bmjopen-2012-002453
  27. Agricola R, Waarsing JH, Reijman M, Bierma-Zeinstra SMA, Weinans H, Thomas GE et al. Cam impingement: defining the presence of a cam deformity by the alpha angle. Data from the CHECK cohort and Chingford cohort. Osteoarthritis and Cartilage. 2013. doi: 10.1016/j.joca.2013.11.007
  28. Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT et al. Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts. PLoS Medicine. 2013; 2(10)
  29. Hauber AB, Arden NK, Mohamed AF, Johnson FR, Peloso PM, Watson DJ et al. A discrete-choice experiment of United Kingdom patients' willingness to risk adverse events for improved function and pain control in osteoarthritis. Osteoarthritis and Cartilage. 2013; 2(21): 289-297
  30. Pollard TCB, Batra RN, Judge A, Watkins B, McNally EG, Gill HS et al. The hereditary predisposition to hip osteoarthritis and its association with abnormal joint morphology. Osteoarthritis and Cartilage. 2013; 2(21): 314-321
  31. Housman L, Arden N, Schnitzer TJ, Birbara C, Conrozier T, Skrepnik N et al. Intra-articular hylastan versus steroid for knee osteoarthritis. Knee Surgery, Sports Traumatology, Arthroscopy. 2013: 1-9
  32. Blumenfeld O, Williams FMK, Hart DJ, Arden NK, Spector TD, Livshits G. Lower limbs composition and radiographic knee osteoarthritis (RKOA) in Chingford sample-A longitudinal study. Archives of Gerontology and Geriatrics. 2013; 1(56): 148-154
  33. Kendal AR, Prieto-Alhambra D, Arden NK, Carr A, Judge A. Mortality rates at 10 years after metal-on-metal hip resurfacing compared with total hip replacement in England: retrospective cohort analysis of hospital episode statistics. BMJ. 2013: f6549
  34. Leighton R, Åkermark C, Therrien R, Richardson JB, Andersson M, Todman MG et al. NASHA hyaluronic acid vs methylprednisolone for knee osteoarthritis: a prospective, multi-centre, randomized, non-inferiority trial. Osteoarthritis and Cartilage. 2013. doi: 10.1016/j.joca.2013.10.009
  35. Hudson G, Panoutsopoulou K, Wilson I, Southam L, Rayner NW, Arden N et al. No Evidence Of An Association Between Mitochondrial DNA Variants And Osteoarthritis In 7393 Cases And 5122 Controls. Annals of the Rheumatic Diseases 72(1):136-139 2013
  36. Culliford D, Maskell J, Judge A, Arden NK. A population-based survival analysis describing the association of body mass index on time to revision for total hip and knee replacements: results from the UK general practice research database. BMJ Open. 2013; 11(3): e003614. doi: 10.1136/bmjopen-2013-003614
  37. Sankar WN, Arden N, Kim YJ, Grodzinsky AJ, Sandell L, Scanzello C et al. Staging of hip osteoarthritis for clinical trials on femoroacetabular impingement. The Journal of the American Academy of Orthopaedic Surgeons. 2013: S33-S38. doi: 10.5435/jaaos-21-07-s33

2012

  1. Elliott KS, Chapman K, Day-Williams A, Panoutsopoulou K, Southam L, Lindgren CM et al. Evaluation Of The Genetic Overlap Between Osteoarthritis With Body Mass Index And Height Using Genome-Wide Association Scan Data. Ann Rheum Dis. 2012 Sep. doi: 10.1136/annrheumdis-2012-202081
  2. Peters MJ, Broer L, Willemen HL, Eiriksdottir G, Hocking LJ, Holliday KL et al. Genome-Wide Association Study Meta-Analysis Of Chronic Widespread Pain: Evidence For Involvement Of The 5P15.2 Region. Ann Rheum Dis. 2012 Sep. doi: 10.1136/annrheumdis-2012-201742
  3. Patel MB, Makepeace AE, Jameson KA, Masterson LM, Holt RI, Swaminathan R et al. Weight In Infancy And Adult Calcium Absorption As Determinants Of Bone Mineral Density In Adult Men: The Hertfordshire Cohort Study. Calcif Tissue Int. 2012 Sep. doi: 10.1007/s00223-012-9648-8
  4. Hooper L, Bowen CJ, Gates L, Culliford DJ, Ball C, Edwards CJ et al. Prognostic Indicators Of Foot-Related Disability In Patients With Rheumatoid Arthritis: Results Of A Prospective Three-Year Study. Arthritis Care Res (Hoboken). 2012 Aug; 8(64): 1116-1124. doi: 10.1002/acr.21672
  5. Prieto-Alhambra D, Nogues X, Javaid MK, Wyman A, Arden NK, Azagra R et al. An Increased Rate Of Falling Leads To A Rise In Fracture Risk In Postmenopausal Women With Self-Reported Osteoarthritis: A Prospective Multinational Cohort Study (Glow). Ann Rheum Dis. 2012 Jun. doi: 10.1136/annrheumdis-2012-201451
  6. Javaid M, Kiran A, Guermazi A, Kwoh K, Zaim S, Carbone L et al. Individual Mri And Radiographic Features Of Knee Oa In Subjects With Unilateral Knee Pain: Health Abc Study. Arthritis Rheum. 2012 Jun. doi: 10.1002/art.34594
  7. Arden NK, Hauber AB, Mohamed AF, Johnson FR, Peloso PM, Watson DJ et al. How Do Physicians Weigh Benefits And Risks Associated With Treatments In Patients With Osteoarthritis In The United Kingdom?. J Rheumatol. 2012 May; 5(39): 1056-1063. doi: 10.3899/jrheum.111066
  8. Pinedo-Villanueva RA, Turner D, Judge A, Raftery JP, Arden NK. Mapping The Oxford Hip Score Onto The Eq-5D Utility Index. Qual Life Res. 2012 Apr. doi: 10.1007/s11136-012-0174-y
  9. Judge A, Arden NK, Cooper C, Kassim Javaid M, Carr AJ, Field RE et al. Predictors of outcomes of total knee replacement surgery. Rheumatology (Oxford). 2012 Apr 24. [Epub ahead of print]
  10. Soni A, Kiran A, Hart DJ, Leyland KM, Goulston L, Cooper C et al. Prevalence Of Reported Knee Pain Over Twelve Years In A Community-Based Cohort. Arthritis Rheum. 2012 Apr; 4(64): 1145-1152. doi: 10.1002/art.33434
  11. Judge A, Arden NK, Kiran A, Price A, Javaid MK, Beard D et al. Interpretation Of Patient-Reported Outcomes For Hip And Knee Replacement Surgery: Identification Of Thresholds Associated With Satisfaction With Surgery. J Bone Joint Surg Br. 2012 Mar; 3(94): 412-418. doi: 10.1302/0301-620X.94B3.27425
  12. Carr AJ, Robertsson O, Graves S, Price AJ, Arden NK, Judge A et al. Knee replacement. Lancet. 2012 Mar 5. [Epub ahead of print]
  13. Culliford DJ, Maskell J, Kiran A, Judge A, Javaid MK, Cooper C et al. The Lifetime Risk Of Total Hip And Knee Arthroplasty: Results From The Uk General Practice Research Database. Osteoarthritis Cartilage. 2012 Mar. doi: 10.1016/j.joca.2012.02.636
  14. Leyland KM, Hart D, Javaid MK, Judge A, Kiran A, Soni A et al. The Natural History Of Radiographic Knee Osteoarthritis: A Fourteen Year Population-Based Cohort Study. Arthritis Rheum. 2012 Mar. doi: 10.1002/art.34415
  15. Prieto-Alhambra D, Servitja S, Javaid MK, Garrigós L, Arden NK, Cooper C et al. Vitamin D Threshold To Prevent Aromatase Inhibitor-Related Bone Loss: The B-Able Prospective Cohort Study. Breast Cancer Res Treat. 2012 Mar. doi: 10.1007/s10549-012-2013-9
  16. Prieto-Alhambra D, Avilés FF, Judge A, Van Staa T, Nogués X, Arden NK et al. Burden Of Pelvis Fracture: A Population-Based Study Of Incidence, Hospitalisation And Mortality. Osteoporos Int. 2012 Feb. doi: 10.1007/s00198-012-1907-z
  17. Pollard TC, Batra RN, Judge A, Watkins B, McNally EG, Gill HS et al. Genetic predisposition to the presence and 5-year clinical progression of hip osteoarthritis. Osteoarthritis Cartilage. 2012 Feb 14. [Epub ahead of print]
  18. Judge A, Javaid MK, Arden NK, Cushnaghan J, Reading I, Croft P et al. A clinical tool to identify patients who are most likely to receive long term improvement in physical function after total hip arthroplasty. Arthritis Care Res (Hoboken). 2012 Jan 9. doi: 10.1002/acr.21594. [Epub ahead of print]
  19. Valdes AM, Doherty S, Muir KR, Zhang W, Maciewicz RA, Wheeler M et al. Genetic Contribution To Radiographic Severity In Osteoarthritis Of The Knee. Annals of the Rheumatic Diseases. 2012; 9(71): 1537-1540
  20. Castaño Betancourt MC, Cailotto F, Kerkhof HJ, Cornelis FMF, Doherty SA, Hart DJ et al. Genome-Wide Association And Functional Studies Identify The Dot1L Gene To Be Involved In Cartilage Thickness And Hip Osteoarthritis. Proceedings of the National Academy of Sciences of the United States of America. 2012; 21(109): 8218-8223
  21. Edwards CJ, Campbell J, Van Staa T, Arden NK. Regional and temporal variation in the treatment of rheumatoid arthritis across the UK: A descriptive register-based cohort study. BMJ Open. 2012; 6(2)
  22. Malfait A-M, Seymour AB, Gao F, Tortorella MD, Graverand-Gastineau M-PHL, Wood LS et al. A Role For Pace4 In Osteoarthritis Pain: Evidence From Human Genetic Association And Null Mutant Phenotype. Annals of the Rheumatic Diseases. 2012

2011

  1. Judge A, Arden NK, Price A, Glyn-Jones S, Beard D, Carr AJ et al. Assessing patients for joint replacement: Can pre-operative Oxford hip and knee scores be used to predict patient satisfaction following joint replacement surgery and to guide patient selection?. J Bone Joint Surg Br. 2011 Dec;93(12):1660-4
  2. Prieto-Alhambra D, Javaid MK, Judge A, Murray D, Carr A, Cooper C et al. Association between bisphosphonate use and implant survival after primary total arthroplasty of the knee or hip: population based retrospective cohort study. BMJ. 2011 Dec 6;343:d7222. doi: 10.1136/bmj.d7222
  3. Muraki S, Dennison E, Jameson K, Boucher BJ, Akune T, Yoshimura N et al. Association of vitamin D status with knee pain and radiographic knee osteoarthritis. Osteoarthritis Cartilage. 2011 Nov;19(11):1301-6. Epub 2011 Aug 16
  4. Villanueva PRA, Turner D, Judge A, Raftery JP, Arden NK. The Beauty Of Mapping: Need The Mean Health-Related Quality Of Life Score For A Group Of Hip Patients And Don'T Have Eq-5D? Just Use The Oxford Hip Score!. VALUE IN HEALTH. 2011 Nov; 7(14): A541
  5. Ghebre MA, Hart DJ, Hakim AJ, Kato BS, Thompson V, Arden NK et al. Association Between Dheas And Bone Loss In Postmenopausal Women: A 15-Year Longitudinal Population-Based Study. CALCIFIED TISSUE INT. 2011 Oct; 4(89): 295-302. doi: 10.1007/s00223-011-9518-9
  6. Goulston LM, Kiran A, Javaid MK, Soni A, White KM, Hart DJ et al. Does Obesity Predict Knee Pain Over Fourteen Years In Women, Independently Of Radiographic Changes?. Arthritis Care Res (Hoboken). 2011 Oct; 10(63): 1398-1406. doi: 10.1002/acr.20546
  7. Kerkhof H, Panagiotou O, Irving M, Esko T, Meulenbelt I, Panoutsopoulou K et al. COMMON VARIANTS IN SKELETAL DYSPLASIA GENES ARE ASSOCIATED WITH OSTEOARTHRITIS. OSTEOARTHRITIS AND CARTILAGE. 2011 Sep: S160-S161
  8. Betancourt MCC, Valdes A, Cornelis F, Kerkhof H, Doherty S, Wheeler M et al. A GENOME WIDE ASSOCIATION STUDY ON JOINT SPACE WIDTH IDENTIFIES A NEW GENE INVOLVED IN CARTILAGE THICKNESS AND OSTEOARTHRITIS. OSTEOARTHRITIS AND CARTILAGE. 2011 Sep: S157-S158
  9. Day-Williams AG, Southam L, Panoutsopoulou K, Rayner NW, Esko T, Estrada K et al. A variant in MCF2L is associated with osteoarthritis. Am J Hum Genet. 2011 Sep 9;89(3):446-50. doi: 10.1016/j.ajhg.2011.08.001. Epub 2011 Aug 25
  10. Fernandez Y, Batra R, Prieto-Alhambra D, Spector T, Javaid K, Arden N. VITAMIN D AND FALLS AND FRACTURES IN OLDER WOMEN. OSTEOARTHRITIS AND CARTILAGE. 2011 Sep: S157
  11. Javaid MK, Prieto-Alhambra D, Lui LY, Cawthon P, Arden NK, Lang T et al. Self-reported weight at birth predicts measures of femoral size but not volumetric BMD in eldery men: MrOS. J Bone Miner Res. 2011 Aug;26(8):1802-7. doi: 10.1002/jbmr.411
  12. Nicholls AS, Kiran A, Pollard TC, Hart D, Arden CP, Spector T et al. The association between hip morphology parameters and 19-year risk of end-stage osteoarthritis in the hip: A nested case-control study. Arthritis Rheum. 2011 Jul 7. doi: 10.1002/art.30523. [Epub ahead of print]
  13. Nicholls AS, Kiran A, Javaid MK, Hart DJ, Spector TD, Carr AJ et al. Change in body mass index during middle age affects risk of total knee arthoplasty due to osteoarthritis: A 19-year prospective study of 1003 women. Knee. 2011 Jul 20. [Epub ahead of print]
  14. Judge A, Cooper C, Arden NK, Williams S, Hobbs N, Dixon D et al. Pre-operative expectation predicts 12-month post-operative outcome among patients undergoing primary total hip replacement in European orthopaedic centres. Osteoarthritis Cartilage. 2011 Jun;19(6):659-67. Epub 2011 Apr 11
  15. Prieto-Alhambra D, Javaid MK, Judge A, Maskell J, Kiran A, Cooper C et al. Bisphosphonate use and risk of post-operative fracture among patients undergoing a total knee replacement for knee osteoarthritis: a propensity score analysis. OSTEOPOROSIS INT. 2011 May;22(5):1555-71. Epub 2010 Aug 7
  16. Valdes AM, Evangelou E, Kerkhof HJ, Tamm A, Doherty SA, Kisand K et al. The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance. ANN RHEUM DIS. 2011 May;70(5):873-5. Epub 2010 Sep 24
  17. Prieto-Alhambra D, Javaid MK, Judge A, Maskell J, Kiran A, de Vries F et al. Fracture risk before and after total hip replacement in patients with osteoarthritis: potential benefits of bisphosphonate use. ARTHRITIS RHEUM-US. 2011 Apr;63(4):992-1001. doi: 10.1002/art.30214
  18. Luqmani R, Suppiah R, Edwards CJ, Phillip R, Maskell J, Culliford D et al. Mortality in Wegener's granulomatosis: a bimodal pattern. RHEUMATOLOGY. 2011 Apr;50(4):697-702. Epub 2010 Nov 25
  19. Williams FMK, Popham M, Hart DJ, de Schepper E, Bierma-Zeinstra S, Hofman A et al. Gdf5 Single-Nucleotide Polymorphism Rs143383 Is Associated With Lumbar Disc Degeneration In Northern European Women. ARTHRITIS RHEUM-US. 2011 Mar; 3(63): 708-712. doi: 10.1002/art.30169
  20. Williams F, Popham M, Hart D, de Schepper E, Bierma-Zeinstra S, Hofman A et al. GDF5 SNP rs143383 is associated with lumbar disc disease in northern European women. ARTHRITIS RHEUM-US. 2011 Mar;63(3):708-12. doi: 10.1002/art.30169
  21. Kerkhof HJ, Doherty M, Arden NK, Abramson SB, Attur M, Bos SD et al. Large-Scale Meta-Analysis Of Interleukin-1 Beta And Interleukin-1 Receptor Antagonist Polymorphisms On Risk Of Radiographic Hip And Knee Osteoarthritis And Severity Of Knee Osteoarthritis. Osteoarthritis Cartilage. 2011 Mar; 3(19): 265-271. doi: 10.1016/j.joca.2010.12.003
  22. Arden NK, Kiran A, Judge A, Biant LC, Javaid MK, Murray DW et al. What is a good patient reported outcome after total hip replacement?. OSTEOARTHR CARTILAGE. 2011 Feb;19(2):155-62. Epub 2010 Oct 15
  23. Prieto-Alhambra D, Javaid MK, Maskell J, Judge A, Nevitt M, Cooper C et al. Changes in Hip Fracture Rate before and after total knee replacement due to Osteoarthritis: a population-based cohort study. ANN RHEUM DIS. 2011 Jan;70(1):134-8. Epub 2010 Oct 26
  24. Southam L, Panoutsopoulou K, Rayner NW, Chapman K, Durrant C, Ferreira T et al. The effect of genome-wide association scan quality control on imputation outcome for common variants. EUR J HUM GENET. 2011 May;19(5):610-614. Epub 2011 Jan 26
  25. Hunter DJ, Arden N, Conaghan PG, Eckstein F, Gold G, Grainger A et al. Definition Of Osteoarthritis On Mri: Results Of A Delphi Exercise. Osteoarthritis and Cartilage. 2011; 8(19): 963-969
  26. Bolland BJRF, Culliford DJ, Maskell J, Latham JM, Dunlop DG, Arden NK. The Effect Of Hip And Knee Arthroplasty On Oral Anti-Inflammatory Use And The Relationship To Body Mass Index: Results From The Uk General Practice Research Database. Osteoarthritis and Cartilage. 2011; 1(19): 29-36
  27. Cooper C, Arden NK. Excess Mortality In Osteoarthritis. BMJ. 2011: d1407
  28. Bowen CJ, Culliford D, Allen R, Beacroft J, Gay A, Hooper L et al. Forefoot Pathology In Rheumatoid Arthritis Identified With Ultrasound May Not Localise To Areas Of Highest Pressure: Cohort Observations At Baseline And Twelve Months. J Foot Ankle Res. 2011; 1(4): 25. doi: 10.1186/1757-1146-4-25
  29. Bolland BJRF, Culliford DJ, Langton DJ, Millington JPS, Arden NK, Latham JM. High Failure Rates With A Large-Diameter Hybrid Metal-On-Metal Total Hip Replacement: Clinical, Radiological And Retrieval Analysis. Journal of Bone and Joint Surgery - Series B. 2011; 5(93 B): 608-615
  30. Valdes AM, De Wilde G, Doherty SA, Lories RJ, Vaughn FL, Laslett LL et al. The Ile585Val Trpv1 Variant Is Involved In Risk Of Painful Knee Osteoarthritis. Annals of the Rheumatic Diseases. 2011
  31. Lalmohamed A, Opdam F, Arden NK, Prieto-Alhambra D, van Staa T, Leufkens HGM et al. Knee Arthroplasty And Risk Of Hip Fracture: A Population-Based, Case-Control Study. Calcified Tissue International. 2011: 1-7

2010

  1. Bowen CJ, Hooper L, Culliford D, Dewbury K, Sampson M, Burridge J et al. Assessment of the natural history of forefoot bursae using ultrasonography in patients with rheumatoid arthritis: a twelve-month investigation. ARTHRIT RHEUM-ARTHR. 2010 Dec;62(12):1756-62. doi: 10.1002/acr.20326
  2. Panoutsopoulou K, Southam L, Elliott KS, Wrayner N, Zhai G, Beazley C et al. Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study. ANN RHEUM DIS. 2010 Dec 21. [Epub ahead of print]
  3. Evangelou E, Valdes AM, Kerkhof HJ, Styrkarsdottir U, Zhu Y, Meulenbelt I et al. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. ANN RHEUM DIS. 2010 Nov 10. [Epub ahead of print]
  4. Bridges JF, Taylor SD, Arden N, Hauber AB, Johnson FR, Watson D et al. Physicians' Stated Preferences Over Benefits And Risks Associated With Nsaid Use In Patients With Osteoarthritis In United Kingdom. VALUE IN HEALTH. 2010 Nov; 7(13): A316
  5. Bridges JF, Taylor SD, Arden N, Hauber AB, Johnson FR, Watson D et al. Preferences Over Benefits And Risks Associated With The Use Of Nsaids: Evidence From Patients Diagnosed With Osteoarthritis (Oa) In Uk. VALUE IN HEALTH. 2010 Nov; 7(13): A312
  6. Kerkhof HJ, Meulenbelt I, Akune T, Arden NK, Aromaa A, Bierma-Zeinstra SM et al. Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. OSTEOARTHR CARTILAGE. 2010 Nov 6. [Epub ahead of print]
  7. Roemer FW, Kassim Javaid M, Guermazi A, Thomas M, Kiran A, Keen R et al. Anatomical distribution of synovitis in knee osteoarthritis and its association with joint effusion assessed on non-enhanced and contrast-enhanced MRI. OSTEOARTHR CARTILAGE. 2010 Oct;18(10):1269-74. Epub 2010 Aug 5
  8. Valdes AM, Arden NK, Vaughn FL, Doherty SA, Leaverton PE, Zhang W et al. Role of the Na(V)1.7 R1150W amino acid change in susceptibility to symptomatic knee osteoarthritis and multiple regional pain. ARTHRIT RHEUM-ARTHR. 2010 Oct 28. [Epub ahead of print]
  9. Ayis S, Arden N, Doherty M, Pollard B, Johnston M, Dieppe P. Applying the impairment, activity limitation, and participation restriction constructs of the ICF model to osteoarthritis and low back pain trials: a reanalysis. J RHEUMATOL. 2010 Sep;37(9):1923-31. Epub 2010 Jul 1
  10. Valdes AM, McWilliams D, Arden NK, Doherty SA, Wheeler M, Muir KR et al. Involvement of different risk factors in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes. ARTHRITIS RHEUM-US. 2010 Sep;62(9):2688-95
  11. Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. LANCET. 2010 Jul 17;376(9736):180-8. Epub 2010 Jun 10
  12. Prieto-Alhambra D, Javaid MK, Servitja S, Arden NK, Martinez-García M, Diez-Perez A et al. Vitamin D threshold to prevent aromatase inhibitor-induced arthralgia: a prospective cohort study. BREAST CANCER RES TR. 2010 Jul 28. [Epub ahead of print]
  13. Bowen CJ, Edwards CJ, Hooper L, Dewbury K, Sampson M, Sawyer S et al. Improvement in symptoms and signs in the forefoot of Patients With Rheumatoid Arthritis treated with Anti-TNF Therapy. J Foot Ankle Res. 2010 Jun 17;3:10
  14. Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Streeten EA et al. Identification of genetic susceptibility loci for vitamin D insufficiency: the SUNLIGHT consortium. LANCET. In press
  15. Valdes AM, Arden NK, Tamm A, Kisand K, Doherty S, Pola E et al. A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis. OSTEOARTHR CARTILAGE. 2010 May;18(5):699-704. Epub 2010 Feb 6
  16. White KM, Chumley A, Petley GW, Edwards CJ, Taylor P, Mays S et al. Changes in proximal hip geometry between medieval and modern Britons. CALCIFIED TISSUE INT. Manuscript submitted and accepted
  17. Harvey N, Mahon P, Robinson S, Nisbet C, Javaid M, Crozier S et al. Different Indices of Fetal Growth Predict Bone Size and Volumetric Density at 4 Years Old. J BONE MINER RES. 2010 Apr;25(4):920-927
  18. Valdes AM, Spector TD, Tamm A, Kisand K, Doherty SA, Dennison EM et al. Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. ARTHRITIS RHEUM-US. 2010 Apr 21. [Epub ahead of print]
  19. Zhang W, Nuki G, Moskowitz RW, Abramson S, Altman RD, Arden NK et al. OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009. OSTEOARTHR CARTILAGE. 2010 Apr;18(4):476-99. Epub 2010 Feb 11. Review
  20. Zhai G, Wang-Sattler R, Hart DJ, Arden NK, Hakim AJ, Illig T et al. Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis. ANN RHEUM DIS. 2010 Apr 13. [Epub ahead of print]
  21. Zhang W, Doherty M, Peat G, Bierma-Zeinstra MA, Arden NK, Bresnihan B et al. EULAR evidence-based recommendations for the diagnosis of knee osteoarthritis. ANN RHEUM DIS. 2010 Mar;69(3):483-9. Epub 2009 Sep 17
  22. Price AJ, Longino D, Rees J, Rout R, Pandit H, Javaid K et al. Are pain and function better measures of outcome than revision rates after TKR in the younger patient?. KNEE. 2010 Jun;17(3):196-9. Epub 2010 Feb 4
  23. Harvey NC, Javaid MK, Arden NK, Poole JR, Crozier SR, Robinson SM et al. Maternal Predictors Of Neonatal Bone Size And Geometry: The Southampton Women'S Survey. JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE. 2010 Feb; 1(1): 35-41. doi: 10.1017/S2040174409990055
  24. Bowen CJ, Culliford D, Dewbury K, Sampson M, Burridge J, Hooper L et al. The clinical importance of ultrasound detectable forefoot bursae in rheumatoid arthritis. RHEUMATOLOGY. 2010 Jan;49(1):191-2. Epub 2009 Sep 30
  25. Culliford DJ, Maskell J, Beard DJ, Murray DW, Price AJ, Arden NK. Temporal trends in hip and knee replacement in the United Kingdom: 1991 to 2006. J BONE JOINT SURG BR. 2010 Jan;92(1):130-5