Research

Nigel Arden

Nigel Arden

Professor Nigel Arden

MBBS, FRCP, MSc, MD

Professor of Rheumatology
Director of Musculoskeletal Epidemiology
Director of Oxford Musculoskeletal BioBank
Deputy Director of Oxford Biomedical Research Unit

Email: nigel.arden@ndorms.ox.ac.uk

Professor Arden trained at St Thomas's Hospital, London, where he also completed four years of research into the genetics of osteoporosis. During this time, he gained an MSc in Epidemiology and an MD.

He moved to the South Coast in 1996 and in 1998 spent six months as Visiting Professor in Epidemiology at the University of San Francisco.

In February 2000 he commenced his post as Consultant Rheumatologist at Southampton General Hospital, and Senior Lecturer in Rheumatology at the University of Southampton. He is based at the Botnar Research Centre, where he continues his research into osteoarthritis and osteoporosis. He currently is a Member of WHO/International Osteoporosis Foundation Committee for e-learning project and the National Osteoporosis Society Scientific Advisory Board; he is an International Osteoporosis Foundation Scientific Ambassador and sits on the EULAR (European League Against Rheumatism) Osteoarthritis Guideline Committee and OARSI (Osteoarthritis Research Society International) Guidelines Committee.

Research Interests:

  • The epidemiology and pathophysiology of osteoarthritis
  • The epidemiology and pathophysiology of osteoporosis
  • The role of vitamin D in musculoskeletal health
  • Clinical trials in common musculoskeletal conditions

Publications

View all publications (the list below shows the past five years). Arranged by year. Sorted by date of publication. Sort by title? Where possible, links point to PubMed. Click icon to switch to Europe PubMed Central UK PubMed Central icon

2014

  1. Kynaston-Pearson F, Ashmore AM, Malak TT, Rombach I, Taylor A, Beard D, Arden NK, Price A, Prieto-Alhambra D, Judge A, Carr AJ, Glyn-Jones S Primary hip replacement prostheses and their evidence base: systematic review of literature British journal of sports medicine. 2014 Aug; 15(48): 1198. doi: 10.1136/bjsports-2014-f6956rep
  2. Hooper L, Bowen CJ, Gates L, Culliford D, Arden NK, Edwards CJ Comparative distribution of ultrasound-detectable forefoot bursae in patients with osteoarthritis and rheumatoid arthritis Arthritis Care and Research. 2014 Jun; 6(66): 869-877. doi: 10.1002/acr.22217
  3. Cherry L, King L, Thomas M, Roemer F, Culliford D, Bowen CJ, Arden NK, Edwards CJ The reliability of a novel magnetic resonance imaging-based tool for the evaluation of forefoot bursae in patients with rheumatoid arthritis: the FFB score Rheumatology (Oxford). 2014 Jun. doi: 10.1093/rheumatology/keu232
  4. Wallace G, Judge A, Alhambra DP, de Vries F, Arden NK, Cooper C The effect of body mass index on the risk of post-operative complications during the six months following total hip replacement or total knee replacement surgery Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2014 May. doi: 10.1016/j.joca.2014.04.013
  5. Styrkarsdottir U, Thorleifsson G, Helgadottir HT, Bomer N, Metrustry S, Bierma-Zeinstra S, Strijbosch AM, Evangelou E, Hart D, Beekman M, Jonasdottir A, Sigurdsson A, Eiriksson FF, Thorsteinsdottir M, Frigge ML, Kong A, Gudjonsson SA, Magnusson OT, Masson G, Hofman A, Arden NK, Ingvarsson T, Lohmander S, Kloppenburg M, Rivadeneira F, Nelissen RG, Spector T, Uitterlinden A, Slagboom PE, Thorsteinsdottir U, Jonsdottir I, Valdes AM, Meulenbelt I, van Meurs J, Jonsson H, Stefansson K Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31 Nature genetics. 2014 May; 5(46): 498-502. doi: 10.1038/ng.2957
  6. Rodriguez-Fontenla C, Calaza M, Gonzalez A, Evangelou E, Ntzani EE, Ioannidis JPA, Valdes AM, Zhai G, Spector TD, Arden N, Carr A, Chapman K, Blanco FJ, Oreiro N, Deloukas P, Panoutsopoulou K, Zeggini E, Doherty M, Esko T, Metspalu A, Garcés Aletá CM, Riancho JA, Gomez-Reino Carnota JJ, Helgadottir H, Jonsdottir I, Styrkarsdottir U, Thorsteinsdottir U, Thorleifsson G, Stefansson K, Hofman A, Kerkhof HJM, Rivadeneira F, Slagboom PE, Uitterlinden AG, Meulenbelt I, Van Meurs JB, Kloppenburg M, Ramos YF, McCaskie A, Loughlin J, Ollier WER, Ralston SH, Tsezou A, Wallis GA, Wilkinson JM, Zhu Y, Felson DT Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies Arthritis and Rheumatology. 2014 Apr; 4(66): 940-949. doi: 10.1002/art.38300
  7. Kluzek S, Bay-Jensen A-C, Spector T, Hart D, Leyland K, Sanchez-Santos M, Arden N, Newton J HIGHER SERUM LEVELS OF CARTILAGE OLIGOMERIC MATRIX PROTEIN (COMP) ARE ASSOCIATED WITH SELF-REPORTED KNEE PAIN OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S74
  8. Rannou F, Peloso PM, Rajagopalan S, Mavros P, Everett SV, Arden N, Conaghan P, Phillips CJ, Moore RA, van de Laar M, Taylor SD LONGITUDINAL ASSESSMENT OF PAIN IN PATIENTS WITH KNEE OSTEOARTHRITIS (OA): USING DATA FROM THE STUDY OF REAL WORLD THERAPIES (SORT) OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S224
  9. Leyland KM, Sanchez-Santos MT, Muraki S, Judge A, Spector TD, Hart DJ, Newton J, Cooper C, Yoshimura N, Arden NK MANUAL LABOR OCCUPATIONS INCREASE THE SHORT-TERM INCIDENCE OF KNEE OSTEOARTHRITIS IN JAPANESE, BUT NOT CAUCASIAN SUBJECTS OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S398
  10. Hardcastle SA, Dieppe P, Gregson CL, Arden NK, Spector TD, Hart DJ, Edwards MH, Dennison E, Cooper C, Williams M, Smith GD, Tobias JH OSTEOPHYTES, ENTHESOPHYTES AND INCREASED BONE MASS TOGETHER MAY HELP TO DEFINE A "BONE-FORMING" SUB-TYPE OF OSTEOARTHRITIS OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S352
  11. van Middelkoop M, Arden N, Atchia I, Birrell F, Chao J, Lambert RG, Ravaud P, Bijlsma JJ, Doherty M, Dziedzic KS, Lohmander S, McAlindon TE, Zhang W, Bierma-Zeinstra SM THE OA TRIAL BANK: META-ANALYSIS OF INDIVIDUAL PATIENT DATA SHOW THAT PATIENTS WITH SEVERE PAIN OR WITH INFLAMMATORY SIGNS DETECTED BY ULTRASOUND ESPECIALLY BENEFIT FROM INTRA-ARTICULAR GLUCOCORTICOIDS FOR KNEE OR HIP OA OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S474-S475
  12. Pinedo-Villanueva R, Turner D, Raftery JP, Cooper C, Arden NK OUTCOMES AFTER TOTAL HIP REPLACEMENT OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S214
  13. Judge A, Batra RN, Murray D, Dieppe PA, Sanchez-Santos MT, Thomas G, Beard D, Javaid MK, Dreinhoefer K, Peter-Guenther K, Cooper C, Arden NK PATIENT REPORTED OUTCOMES FOLLOWING PRIMARY HIP REPLACEMENT SURGERY: DEVELOPMENT AND INTERNAL VALIDATION OF A PROGNOSTIC TOOL OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S209
  14. Soni A, Batra R, Leyland K, Gwylim S, Spector T, Hart D, Arden N, Cooper C, Tracey I, Javaid M PRAGMATIC APPROACH TO QUANTITATIVE SENSORY TESTING IN KNEE OSTEOARTHRITIS: MEASURES OF MECHANICAL PAIN SENSITIVITY PREDICT CONCORDANT PAIN AND STRUCTURAL STATUS OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S418
  15. Soni A, Gwylim S, Arden N, Tracey I, Price A, Javaid M PRE-OPERATIVE EXPERIMENTAL THERMAL SENSITIVITY PREDICTS OXFORD KNEE SCORE 1-YEAR POST-OPERATIVELY: A PRELIMINARY STUDY OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S414-S415
  16. Hardcastle SA, Dieppe P, Gregson CL, Hunter D, Thomas G, Arden NK, Spector TD, Hart DJ, Laugharne MJ, Clague GA, Edwards MH, Dennison E, Cooper C, Williams M, Smith GD, Tobias JH THE PREVALENCE OF RADIOGRAPHIC HIP OSTEOARTHRITIS IS INCREASED IN HIGH BONE MASS; A CASE-CONTROL STUDY OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S343
  17. Pinedo-Villanueva R, Turner D, Raftery JP, Cooper C, Arden NK, Grp C PRIMARY CARE COSTS ATTRIBUTABLE TO OSTEOARTHRITIS BEFORE TOTAL HIP REPLACEMENT OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S210-S211
  18. Toner A, Wallace G, Rowe J, Garden S, Alhambra DP, Arden NK THE RELATIONSHIP BETWEEN PRE-OPERATIVE \'TIMED GET UP AND GO\' AND LENGTH OF STAY IN PRIMARY ELECTIVE HIP AND KNEE ARTHROPLASTY PATIENTS OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S380-S381
  19. Leyland KM, Sanchez-Santos MT, Kluzek S, Prieto-Alhambra D, Spector TD, Hart DJ, Newton J, Arden NK SUBJECTS WITH SELF-REPORTED BASELINE INJURY HAVE AN INCREASED RISK OF SYMPTOMATIC RADIOGRAPHIC KNEE OSTEOARTHRITIS OVER TWENTY-YEARS OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S385
  20. Culliford DJ, Judge A, Prieto-Alhambra D, Cooper C, Arden NK UK TEMPORAL TRENDS FOR TIME FROM DIAGNOSIS OF HIP/KNEE OSTEOARTHRITIS TO JOINT REPLACEMENT OSTEOARTHRITIS AND CARTILAGE. 2014 Apr: S213
  21. Muñoz-Ortego J, Vestergaard P, Rubio JB, Wordsworth P, Judge A, Javaid MK, Arden NK, Cooper C, Díez-Pérez A, Prieto-Alhambra D Ankylosing Spondylitis is Associated with an Increased Risk of Vertebral and Non-Vertebral Clinical Fractures: A Population-Based Cohort Study Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2014 Mar. doi: 10.1002/jbmr.2217
  22. McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, Hawker GA, Henrotin Y, Hunter DJ, Kawaguchi H, Kwoh K, Lohmander S, Rannou F, Roos EM, Underwood M OARSI guidelines for the non-surgical management of knee osteoarthritis Osteoarthritis and Cartilage. 2014 Mar; 3(22): 363-388. doi: 10.1016/j.joca.2014.01.003
  23. Prieto-Alhambra D, Premaor MO, Avilés FF, Castro AS, Javaid MK, Nogués X, Arden NK, Cooper C, Compston JE, Diez-Perez A Relationship Between Mortality and BMI After Fracture: A Population-Based Study of Men and Women Aged ≥40 Years Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2014 Feb. doi: 10.1002/jbmr.2209
  24. Judge A, Batra RN, Thomas G, Beard D, Javaid MK, Murray D, Dieppe PA, Dreinhoefer KE, Peter-Guenther K, Field R, Cooper C, Arden NK Body mass index is not a clinically meaningful predictor of patient reported outcomes of primary hip replacement surgery: prospective cohort study Osteoarthritis Cartilage. 2014 Jan. doi: 10.1016/j.joca.2013.12.018
  25. Prieto-Alhambra D, Javaid MK, Judge A, Maskell J, Cooper C, Arden NK Hormone replacement therapy and mid-term implant survival following knee or hip arthroplasty for osteoarthritis: a population-based cohort study Ann Rheum Dis. 2014 Jan. doi: 10.1136/annrheumdis-2013-204043
  26. Judge A, Murphy RJ, Maxwell R, Arden NK, Carr AJ Temporal trends and geographical variation in the use of subacromial decompression and rotator cuff repair of the shoulder in England Bone Joint J. 2014 Jan; 1(96): 70-74. doi: 10.1302/0301-620X.96B1.32556
  27. James SJ, Mirza SB, Culliford DJ, Taylor PA, Carr AJ, Arden NK Baseline bone mineral density and boneturnover in pre-operative hip and knee arthroplasty patients Bone Joint Res. 2014; 1(3): 14-19. doi: 10.1302/2046-3758.31.2000218
  28. Valdes AM, Hart D, Spector TD, Meulenbelt I, Slagboom EP, Chassaing E, Arden NK, Bierma-Zeinstra S, Hofman A, Uitterlinden AG, Karsdal M, Bay-Jensen AC, Kloppenburg M, van Meurs JB, Kroon HM Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis Osteoarthritis and Cartilage. 2014. doi: 10.1016/j.joca.2014.02.007

2013

  1. Hiligsmann M, Bruyère O, Reginster J-Y, Cooper C, Arden N, Boers M, Branco JC, Luisa Brandi M, Guillemin F, Hochberg MC, Hunter DJ, Kanis JA, Kvien TK, Laslop A, Tsouderos Y, Pelletier J-P, Pinto D, Reiter-Niesert S, Rizzoli R, Rovati LC, Severens JLH, Silverman S, Tugwell P Health economics in the field of osteoarthritis: An Expert's consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) Seminars in Arthritis and Rheumatism. 2013 Dec; 3(43): 303-313. doi: 10.1016/j.semarthrit.2013.07.003
  2. Kynaston-Pearson F, Ashmore AM, Malak TT, Rombach I, Taylor A, Beard D, Arden NK, Price A, Prieto-Alhambra D, Judge Senior A, Carr AJ, Glyn-Jones S Primary hip replacement prostheses and their evidence base: Systematic review of literature BMJ (Online). 2013 Dec. doi: 10.1136/bmj.f6956
  3. Prieto-Alhambra D, Morros R, Arden N ASSOCIATION BETWEEN CHONDROITIN SULPHATE USE AND THE RISK OF TOTAL KNEE ARTRHOPLASTY IN OSTEOARTHITIS PATIENTS: A PROPENSITY-SCORE MATCHED COHORT STUDY BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2013 Oct: 34
  4. Judge A, Arden NK Decision making in knee arthroplasty Rheumatology (Oxford). 2013 Oct. doi: 10.1093/rheumatology/ket339
  5. Arden NK, Akermark C, Andersson M, Todman MG, Altman RD A randomized saline-controlled trial of NASHA hyaluronic acid for knee osteoarthritis Curr Med Res Opin. 2013 Oct. doi: 10.1185/03007995.2013.855631
  6. Robson JC, Kiran A, Arden N, Luqmani RA, Maskell J, Culliford D, Hutchings A, Dasgupta B, Hamilton W, Emin A The relative risk of aortic aneurysm in patients with giant cell arteritis compared with the general population of the UK Annals of the Rheumatic Diseases. 2013 Oct. doi: 10.1136/annrheumdis-2013-204113
  7. Beard D, Price A, Carr A, Arden N, Cooper C, Davies L, Murray D, Fitzpatrick R, Campbell H, Cook J, Campbell M, Doll H Total or Partial Knee Arthroplasty Trial - TOPKAT: Study protocol for a randomised controlled trial Trials. 2013 Sep; 1(14). doi: 10.1186/1745-6215-14-292
  8. Panoutsopoulou K, Zeggini E, Metrustry S, Hart DJ, Spector TD, Valdes AM, Doherty SA, Zhang W, Wheeler M, Doherty M, Laslett LL, Jones G, Maciewicz RA, Muir KR, Cooper C, Arden NK, Cicuttini FM The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: A mendelian randomisation study Annals of the Rheumatic Diseases. 2013 Aug. doi: 10.1136/annrheumdis-2013-203772
  9. Evangelou E, Ntzani EE, Tsilidis KK, Ioannidis JPA, Metrustry S, Spector TD, Valdes AM, Kerkhof HJ, Rivadeneira F, Uitterlinden AG, van Meurs JBJ, Styrkarsdottir U, Thorleifsson G, Helgadottir HT, Thorsteinsdottir U, Jonsdottir I, Stefansson K, Bos SD, Ramos YFM, Slagboom PE, Meulenbelt I, Esko T, Milani L, Metspalu A, Evans DS, Parimi N, Panoutsopoulou K, Day-Williams AG, Deloukas P, Southam L, Zeggini E, Arden N, Carr A, Chapman K, Aslam N, Bellamy N, Birrell F, McCaskie A, Loughlin J, Reed MR, Blanco FJ, Doherty M, Engström G, Nilsson PM, Hofman A, Ingvarsson T, Jonsson H, Keis A, Keurentjes JC, Nelissen RGHH, Kloppenburg M, Lind PA, Martin NG, Montgomery GW, Nevitt MC, Ollier WER, Rai A, Ralston SH, Riancho JA, Rodriguez-Fontenla C, Gonzalez A, Tsezou A, Wallis GA, Wilkinson JM, Lane NE, Lohmander LS A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip Annals of the Rheumatic Diseases. 2013 Aug. doi: 10.1136/annrheumdis-2012-203114
  10. Bowen CJ, Hooper L, Edwards CJ, Arden NK Using ultrasound to image the foot in rheumatoid arthritis: Current understanding, challenges and future scope Imaging in Medicine. 2013 Aug; 4(5): 347-356. doi: 10.2217/iim.13.37
  11. Agricola R, Waarsing JH, Bierma-Zeinstra SMA, Arden NK, Carr AJ, Thomas GE, Glyn-Jones S, Weinans H Cam impingement of the hip-a risk factor for hip osteoarthritis Nature Reviews Rheumatology. 2013 Jul. doi: 10.1038/nrrheum.2013.114
  12. Neogi T, Soni A, Cooper C, Arden NK, Doherty SA, Zhang W, Wheeler M, Doherty M, Valdes AM, Laslett LL, Jones G, Maciewicz RA, Hart DJ, Spector TD, Muir KR, Cicuttini F, Nevitt M, Liu Y Contribution of the COMT Val158Met variant to symptomatic knee osteoarthritis Annals of the Rheumatic Diseases. 2013 Jul. doi: 10.1136/annrheumdis-2013-203836
  13. Arden NK, Leyland K Osteoarthritis year 2013 in review: Clinical Osteoarthritis Cartilage. 2013 Jul. doi: 10.1016/j.joca.2013.06.021
  14. Boucas SB, Lennie KH, Dziedzic K, Arden N, Burridge J, Hammond A, Stokes M, Lewis M, Gooberman-Hill R, Coales K, Adams J DIFFERENCES BETWEEN SERVICE PROVIDERS AND USERS WHEN DEFINING FEASIBLE OPTIMAL NHS OCCUPATIONAL THERAPY TREATMENT FOR PATIENTS WITH THUMB BASE OA: RESULTS FROM A DELPHI STUDY ANNALS OF THE RHEUMATIC DISEASES. 2013 Jun: 1083
  15. Prieto-Alhambra D, Judge A, Arden NK, Cooper C, Lyles KW, Javaid MK Fracture prevention in patients with cognitive impairment presenting with a hip fracture: secondary analysis of data from the HORIZON Recurrent Fracture Trial Osteoporos Int. 2013 Jun. doi: 10.1007/s00198-013-2420-8
  16. Prieto-Alhambra D, Judge A, Javaid MK, Cooper C, Diez-Perez A, Arden NK Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints Ann Rheum Dis. 2013 Jun. doi: 10.1136/annrheumdis-2013-203355
  17. Prieto-Alhambra D, Leyland K, Judge A, Javaid MK, Cooper C, Arden NK THE INFLUENCE OF OVERWEIGHT/OBESITY ON THE RISK OF TOTAL KNEE ARTHROPLASTY AMONGST PATIENTS WITH NEWLY DIAGNOSED KNEE OSTEOARTHRITIS: A POPULATION-BASED COHORT STUDY ANNALS OF THE RHEUMATIC DISEASES. 2013 Jun: 339-340
  18. Prieto-Alhambra D, Pagès-Castellà A, Wallace G, Javaid M, Judge A, Nogués X, Arden N, Cooper C, Diez-Perez A Predictors of fracture while on treatment with oral bisphosphonates: A population-based cohort study J Bone Miner Res. 2013 Jun. doi: 10.1002/jbmr.2011
  19. Soni A, Batra R, Gwilym S, Spector T, Hart D, Arden N, Cooper C, Tracey I, Javaid M Neuropathic features of joint pain: A community-based study Arthritis Rheum. 2013 Apr. doi: 10.1002/art.37962
  20. Robson J, Kiran A, Maskell J, Hutchings A, Arden N, Dasgupta B, Hamilton W, Culliford D, Emin A, Luqmani R The relative risk of aortic aneurysm in patients with giant cell arteritis compared with the general population of the UK PRESSE MEDICALE. 2013 Apr; 4(42): 672-673. doi: 10.1016/j.lpm.2013.02.052
  21. Naidoo S, Bowen C, Redmond A, Arden N Training the next generation of clinical researchers: Evaluation of a graduate podiatrist research internship in rheumatology Journal of Foot and Ankle Research. 2013 Apr; 1(6). doi: 10.1186/1757-1146-6-15
  22. Javaid M, Arden N Bone and osteoarthritis: What is the relationship? Arthritis Rheum. 2013 Mar. doi: 10.1002/art.37924
  23. Kingsbury SR, Grainger A, Wakefield RJ, Conaghan PG, Tharmanathan P, Adamson J, Cockayne S, Hewitt CE, Torgerson DJ, Arden NK, Birrell F, Dickson J, Doherty M, Dziedzic KS, O'Neill TW, Scott DL, Vincent TL, Watt FE Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis (HERO): Study protocol for a randomized controlled trial Trials. 2013 Mar; 1(14). doi: 10.1186/1745-6215-14-64
  24. Palmer AJ, Thomas GE, Pollard TC, Rombach I, Taylor A, Arden N, Beard DJ, Andrade AJ, Carr AJ, Glyn-Jones S The feasibility of performing a randomised controlled trial for femoroacetabular impingement surgery Bone Joint Res. 2013 Feb; 2(2): 33-40. doi: 10.1302/2046-3758.22.2000137
  25. Williams DP, Price AJ, Beard DJ, Hadfield SG, Arden NK, Murray DW, Field RE The Effects Of Age On Patient-Reported Outcome Measures In Total Knee Replacements Bone Joint J. 2013 Jan; 1(95-B): 38-44. doi: 10.1302/0301-620X.95B1.28061
  26. Blumenfeld O, Livshits G, Williams FMK, Hart DJ, Spector TD, Arden N Association between cartilage and bone biomarkers and incidence of radiographic knee osteoarthritis (RKOA) in UK females: a prospective study Osteoarthritis and Cartilage. 2013. doi: 10.1016/j.joca.2013.04.009
  27. Judge A, Arden NK, Batra RN, Thomas G, Beard D, Javaid MK, Cooper C, Murray D The association of patient characteristics and surgical variables on symptoms of pain and function over 5 years following primary hip-replacement surgery: a prospective cohort study BMJ Open. 2013; 3(3). doi: 10.1136/bmjopen-2012-002453
  28. Agricola R, Waarsing JH, Reijman M, Bierma-Zeinstra SMA, Weinans H, Thomas GE, Carr AJ, Glyn-Jones S, Arden NK Cam impingement: defining the presence of a cam deformity by the alpha angle. Data from the CHECK cohort and Chingford cohort Osteoarthritis and Cartilage. 2013. doi: 10.1016/j.joca.2013.11.007
  29. Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z, Li R, Houston DK, Wood AR, Michaëlsson K, Vandenput L, Zgaga L, Yerges-Armstrong LM, McCarthy MI, Dupuis J, Kaakinen M, Kleber ME, Jameson K, Arden N, Raitakari O, Viikari J, Lohman KK, Ferrucci L, Melhus H, Ingelsson E, Byberg L, Lind L, Lorentzon M, Salomaa V, Campbell H, Dunlop M, Mitchell BD, Herzig K-H, Pouta A, Hartikainen A-L, Streeten EA, Theodoratou E, Jula A, Wareham NJ, Ohlsson C, Frayling TM, Kritchevsky SB, Spector TD, Richards JB, Lehtimäki T, Ouwehand WH, Kraft P, Cooper C, März W, Power C, Loos RJF, Wang TJ, Järvelin M-R, Whittaker JC, Hingorani AD, Hyppönen E Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts PLoS Medicine. 2013; 2(10)
  30. Hauber AB, Arden NK, Mohamed AF, Johnson FR, Peloso PM, Watson DJ, Mavros P, Gammaitoni A, Sen SS, Taylor SD A discrete-choice experiment of United Kingdom patients' willingness to risk adverse events for improved function and pain control in osteoarthritis Osteoarthritis and Cartilage. 2013; 2(21): 289-297
  31. Pollard TCB, Batra RN, Judge A, Watkins B, McNally EG, Gill HS, Thomas GER, Glyn-Jones S, Arden NK, Carr AJ The hereditary predisposition to hip osteoarthritis and its association with abnormal joint morphology Osteoarthritis and Cartilage. 2013; 2(21): 314-321
  32. Housman L, Arden N, Schnitzer TJ, Birbara C, Conrozier T, Skrepnik N, Wei N, Bockow B, Waddell D, Tahir H, Hammond A, Goupille P, Sanson B-J, Elkins C, Bailleul F Intra-articular hylastan versus steroid for knee osteoarthritis Knee Surgery, Sports Traumatology, Arthroscopy. 2013: 1-9
  33. Blumenfeld O, Williams FMK, Hart DJ, Arden NK, Spector TD, Livshits G Lower limbs composition and radiographic knee osteoarthritis (RKOA) in Chingford sample-A longitudinal study Archives of Gerontology and Geriatrics. 2013; 1(56): 148-154
  34. Kendal AR, Prieto-Alhambra D, Arden NK, Carr A, Judge A Mortality rates at 10 years after metal-on-metal hip resurfacing compared with total hip replacement in England: retrospective cohort analysis of hospital episode statistics BMJ. 2013: f6549
  35. Leighton R, Åkermark C, Therrien R, Richardson JB, Andersson M, Todman MG, Arden NK NASHA hyaluronic acid vs methylprednisolone for knee osteoarthritis: a prospective, multi-centre, randomized, non-inferiority trial Osteoarthritis and Cartilage. 2013. doi: 10.1016/j.joca.2013.10.009
  36. Hudson G, Panoutsopoulou K, Wilson I, Southam L, Rayner NW, Arden N, Birrell F, Carluke I, Carr A, Chapman K, Deloukas P, Doherty M, McCaskie A, Ollier WER, Ralston SH, Reed MR, Spector TD, Valdes AM, Wallis GA, Wilkinson JM, Zeggini E, Samuels DC, Loughlin J, Chinnery PF No Evidence Of An Association Between Mitochondrial DNA Variants And Osteoarthritis In 7393 Cases And 5122 Controls Annals of the Rheumatic Diseases 72(1):136-139 2013
  37. Culliford D, Maskell J, Judge A, Arden NK A population-based survival analysis describing the association of body mass index on time to revision for total hip and knee replacements: results from the UK general practice research database BMJ Open. 2013; 11(3): e003614. doi: 10.1136/bmjopen-2013-003614

2012

  1. Elliott KS, Chapman K, Day-Williams A, Panoutsopoulou K, Southam L, Lindgren CM, Arden N, Aslam N, Birrell F, Carluke I, Carr A, Deloukas P, Doherty M, Loughlin J, McCaskie A, Ollier WE, Rai A, Ralston S, Reed MR, Spector TD, Valdes AM, Wallis GA, Wilkinson M, Zeggini E Evaluation Of The Genetic Overlap Between Osteoarthritis With Body Mass Index And Height Using Genome-Wide Association Scan Data Ann Rheum Dis. 2012 Sep. doi: 10.1136/annrheumdis-2012-202081
  2. Peters MJ, Broer L, Willemen HL, Eiriksdottir G, Hocking LJ, Holliday KL, Horan MA, Meulenbelt I, Neogi T, Popham M, Schmidt CO, Soni A, Valdes AM, Amin N, Dennison EM, Eijkelkamp N, Harris TB, Hart DJ, Hofman A, Huygen FJ, Jameson KA, Jones GT, Launer LJ, Kerkhof HJ, de Kruijf M, McBeth J, Kloppenburg M, Ollier WE, Oostra B, Payton A, Rivadeneira F, Smith BH, Smith AV, Stolk L, Teumer A, Thomson W, Uitterlinden AG, Wang K, van Wingerden SH, Arden NK, Cooper C, Felson D, Gudnason V, Macfarlane GJ, Pendleton N, Slagboom PE, Spector TD, Völzke H, Kavelaars A, van Duijn CM, Williams FM, van Meurs JB Genome-Wide Association Study Meta-Analysis Of Chronic Widespread Pain: Evidence For Involvement Of The 5P15.2 Region Ann Rheum Dis. 2012 Sep. doi: 10.1136/annrheumdis-2012-201742
  3. Patel MB, Makepeace AE, Jameson KA, Masterson LM, Holt RI, Swaminathan R, Javaid MK, Cooper C, Arden NK Weight In Infancy And Adult Calcium Absorption As Determinants Of Bone Mineral Density In Adult Men: The Hertfordshire Cohort Study Calcif Tissue Int. 2012 Sep. doi: 10.1007/s00223-012-9648-8
  4. Hooper L, Bowen CJ, Gates L, Culliford DJ, Ball C, Edwards CJ, Arden NK Prognostic Indicators Of Foot-Related Disability In Patients With Rheumatoid Arthritis: Results Of A Prospective Three-Year Study Arthritis Care Res (Hoboken). 2012 Aug; 8(64): 1116-1124. doi: 10.1002/acr.21672
  5. Prieto-Alhambra D, Nogues X, Javaid MK, Wyman A, Arden NK, Azagra R, Cooper C, Adachi JD, Boonen S, Chapurlat RD, Compston JE, Gehlbach SH, Greenspan SL, Hooven FH, Netelenbos JC, Pfeilschifter J, Rossini M, Sambrook PN, Silverman S, Siris ES, Watts NB, Díez-Pérez A An Increased Rate Of Falling Leads To A Rise In Fracture Risk In Postmenopausal Women With Self-Reported Osteoarthritis: A Prospective Multinational Cohort Study (Glow) Ann Rheum Dis. 2012 Jun. doi: 10.1136/annrheumdis-2012-201451
  6. Javaid M, Kiran A, Guermazi A, Kwoh K, Zaim S, Carbone L, Harris T, McCulloch CE, Arden N, Lane N, Felson D, Nevitt M Individual Mri And Radiographic Features Of Knee Oa In Subjects With Unilateral Knee Pain: Health Abc Study Arthritis Rheum. 2012 Jun. doi: 10.1002/art.34594
  7. Arden NK, Hauber AB, Mohamed AF, Johnson FR, Peloso PM, Watson DJ, Mavros P, Gammaitoni A, Sen SS, Taylor SD How Do Physicians Weigh Benefits And Risks Associated With Treatments In Patients With Osteoarthritis In The United Kingdom? J Rheumatol. 2012 May; 5(39): 1056-1063. doi: 10.3899/jrheum.111066
  8. Pinedo-Villanueva RA, Turner D, Judge A, Raftery JP, Arden NK Mapping The Oxford Hip Score Onto The Eq-5D Utility Index Qual Life Res. 2012 Apr. doi: 10.1007/s11136-012-0174-y
  9. Judge A, Arden NK, Cooper C, Kassim Javaid M, Carr AJ, Field RE, Dieppe PA Predictors of outcomes of total knee replacement surgery. Rheumatology (Oxford). 2012 Apr 24. [Epub ahead of print]
  10. Soni A, Kiran A, Hart DJ, Leyland KM, Goulston L, Cooper C, Javaid MK, Spector TD, Arden NK Prevalence Of Reported Knee Pain Over Twelve Years In A Community-Based Cohort Arthritis Rheum. 2012 Apr; 4(64): 1145-1152. doi: 10.1002/art.33434
  11. Judge A, Arden NK, Kiran A, Price A, Javaid MK, Beard D, Murray D, Field RE Interpretation Of Patient-Reported Outcomes For Hip And Knee Replacement Surgery: Identification Of Thresholds Associated With Satisfaction With Surgery J Bone Joint Surg Br. 2012 Mar; 3(94): 412-418. doi: 10.1302/0301-620X.94B3.27425
  12. Carr AJ, Robertsson O, Graves S, Price AJ, Arden NK, Judge A, Beard DJ Knee replacement. Lancet. 2012 Mar 5. [Epub ahead of print]
  13. Culliford DJ, Maskell J, Kiran A, Judge A, Javaid MK, Cooper C, Arden NK The Lifetime Risk Of Total Hip And Knee Arthroplasty: Results From The Uk General Practice Research Database Osteoarthritis Cartilage. 2012 Mar. doi: 10.1016/j.joca.2012.02.636
  14. Leyland KM, Hart D, Javaid MK, Judge A, Kiran A, Soni A, Goulston LM, Cooper C, Spector TD, Arden NK The Natural History Of Radiographic Knee Osteoarthritis: A Fourteen Year Population-Based Cohort Study Arthritis Rheum. 2012 Mar. doi: 10.1002/art.34415
  15. Prieto-Alhambra D, Servitja S, Javaid MK, Garrigós L, Arden NK, Cooper C, Albanell J, Tusquets I, Diez-Perez A, Nogues X Vitamin D Threshold To Prevent Aromatase Inhibitor-Related Bone Loss: The B-Able Prospective Cohort Study Breast Cancer Res Treat. 2012 Mar. doi: 10.1007/s10549-012-2013-9
  16. Prieto-Alhambra D, Avilés FF, Judge A, Van Staa T, Nogués X, Arden NK, Díez-Pérez A, Cooper C, Javaid MK Burden Of Pelvis Fracture: A Population-Based Study Of Incidence, Hospitalisation And Mortality Osteoporos Int. 2012 Feb. doi: 10.1007/s00198-012-1907-z
  17. Pollard TC, Batra RN, Judge A, Watkins B, McNally EG, Gill HS, Arden NK, Carr AJ Genetic predisposition to the presence and 5-year clinical progression of hip osteoarthritis. Osteoarthritis Cartilage. 2012 Feb 14. [Epub ahead of print]
  18. Judge A, Javaid MK, Arden NK, Cushnaghan J, Reading I, Croft P, Dieppe PA, Cooper C A clinical tool to identify patients who are most likely to receive long term improvement in physical function after total hip arthroplasty. Arthritis Care Res (Hoboken). 2012 Jan 9. doi: 10.1002/acr.21594. [Epub ahead of print]
  19. Valdes AM, Doherty S, Muir KR, Zhang W, Maciewicz RA, Wheeler M, Arden N, Cooper C, Doherty M Genetic Contribution To Radiographic Severity In Osteoarthritis Of The Knee Annals of the Rheumatic Diseases. 2012; 9(71): 1537-1540
  20. Castaño Betancourt MC, Cailotto F, Kerkhof HJ, Cornelis FMF, Doherty SA, Hart DJ, Hofman A, Luyten FP, Maciewicz RA, Mangino M, Metrustry S, Muir K, Peters MJ, Rivadeneira F, Wheeler M, Zhang W, Arden N, Spector TD, Uitterlinden AG, Doherty M, Lories RJU, Valdes AM, Van Meurs JBJ Genome-Wide Association And Functional Studies Identify The Dot1L Gene To Be Involved In Cartilage Thickness And Hip Osteoarthritis Proceedings of the National Academy of Sciences of the United States of America. 2012; 21(109): 8218-8223
  21. Edwards CJ, Campbell J, Van Staa T, Arden NK Regional and temporal variation in the treatment of rheumatoid arthritis across the UK: A descriptive register-based cohort study BMJ Open. 2012; 6(2)
  22. Malfait A-M, Seymour AB, Gao F, Tortorella MD, Graverand-Gastineau M-PHL, Wood LS, Doherty M, Doherty S, Zhang W, Arden NK, Vaughn FL, Leaverton PE, Spector TD, Hart DJ, Maciewicz RA, Muir KR, Das R, Sorge RE, Sotocinal SG, Schorscher-Petcu A, Valdes AM, Mogil JS A Role For Pace4 In Osteoarthritis Pain: Evidence From Human Genetic Association And Null Mutant Phenotype Annals of the Rheumatic Diseases. 2012

2011

  1. Judge A, Arden NK, Price A, Glyn-Jones S, Beard D, Carr AJ, Dawson J, Fitzpatrick R, Field RE Assessing patients for joint replacement: Can pre-operative Oxford hip and knee scores be used to predict patient satisfaction following joint replacement surgery and to guide patient selection? J Bone Joint Surg Br. 2011 Dec;93(12):1660-4.
  2. Prieto-Alhambra D, Javaid MK, Judge A, Murray D, Carr A, Cooper C, Arden NK Association between bisphosphonate use and implant survival after primary total arthroplasty of the knee or hip: population based retrospective cohort study. BMJ. 2011 Dec 6;343:d7222. doi: 10.1136/bmj.d7222.
  3. Muraki S, Dennison E, Jameson K, Boucher BJ, Akune T, Yoshimura N, Judge A, Arden NK, Javaid K, Cooper C Association of vitamin D status with knee pain and radiographic knee osteoarthritis. Osteoarthritis Cartilage. 2011 Nov;19(11):1301-6. Epub 2011 Aug 16.
  4. Villanueva PRA, Turner D, Judge A, Raftery JP, Arden NK The Beauty Of Mapping: Need The Mean Health-Related Quality Of Life Score For A Group Of Hip Patients And Don'T Have Eq-5D? Just Use The Oxford Hip Score! VALUE IN HEALTH. 2011 Nov; 7(14): A541
  5. Ghebre MA, Hart DJ, Hakim AJ, Kato BS, Thompson V, Arden NK, Spector TD, Zhai GJ Association Between Dheas And Bone Loss In Postmenopausal Women: A 15-Year Longitudinal Population-Based Study CALCIFIED TISSUE INT. 2011 Oct; 4(89): 295-302. doi: 10.1007/s00223-011-9518-9
  6. Goulston LM, Kiran A, Javaid MK, Soni A, White KM, Hart DJ, Spector TD, Arden NK Does Obesity Predict Knee Pain Over Fourteen Years In Women, Independently Of Radiographic Changes? Arthritis Care Res (Hoboken). 2011 Oct; 10(63): 1398-1406. doi: 10.1002/acr.20546
  7. Day-Williams AG, Southam L, Panoutsopoulou K, Rayner NW, Esko T, Estrada K, Helgadottir HT, Hofman A, Ingvarsson T, Jonsson H, Keis A, Kerkhof HJ, Thorleifsson G, Arden NK, Carr A, Chapman K, Deloukas P, Loughlin J, McCaskie A, Ollier WE, Ralston SH, Spector TD, Wallis GA, Wilkinson JM, Aslam N, Birell F, Carluke I, Joseph J, Rai A, Reed M, Walker K, Doherty SA, Jonsdottir I, Maciewicz RA, Muir KR, Metspalu A, Rivadeneira F, Stefansson K, Styrkarsdottir U, Uitterlinden AG, van Meurs JB, Zhang W, Valdes AM, Doherty M, Zeggini E A variant in MCF2L is associated with osteoarthritis. Am J Hum Genet. 2011 Sep 9;89(3):446-50. doi: 10.1016/j.ajhg.2011.08.001. Epub 2011 Aug 25.
  8. Javaid MK, Prieto-Alhambra D, Lui LY, Cawthon P, Arden NK, Lang T, Lane NE, Orwoll E, Barrett-Conner E, Nevitt MC, Cooper C, Cummings SR Self-reported weight at birth predicts measures of femoral size but not volumetric BMD in eldery men: MrOS. J Bone Miner Res. 2011 Aug;26(8):1802-7. doi: 10.1002/jbmr.411.
  9. Nicholls AS, Kiran A, Pollard TC, Hart D, Arden CP, Spector T, Gill HS, Murray DW, Carr AJ, Arden NK The association between hip morphology parameters and 19-year risk of end-stage osteoarthritis in the hip: A nested case-control study. Arthritis Rheum. 2011 Jul 7. doi: 10.1002/art.30523. [Epub ahead of print]
  10. Nicholls AS, Kiran A, Javaid MK, Hart DJ, Spector TD, Carr AJ, Arden NK Change in body mass index during middle age affects risk of total knee arthoplasty due to osteoarthritis: A 19-year prospective study of 1003 women. Knee. 2011 Jul 20. [Epub ahead of print]
  11. Judge A, Cooper C, Arden NK, Williams S, Hobbs N, Dixon D, Günther KP, Dreinhoefer K, Dieppe PA Pre-operative expectation predicts 12-month post-operative outcome among patients undergoing primary total hip replacement in European orthopaedic centres. Osteoarthritis Cartilage. 2011 Jun;19(6):659-67. Epub 2011 Apr 11.
  12. Prieto-Alhambra D, Javaid MK, Judge A, Maskell J, Kiran A, Cooper C, Arden NK Bisphosphonate use and risk of post-operative fracture among patients undergoing a total knee replacement for knee osteoarthritis: a propensity score analysis. OSTEOPOROSIS INT. 2011 May;22(5):1555-71. Epub 2010 Aug 7.
  13. Valdes AM, Evangelou E, Kerkhof HJ, Tamm A, Doherty SA, Kisand K, Kerna I, Uitterlinden A, Hofman A, Rivadeneira F, Cooper C, Dennison EM, Zhang W, Muir KR, Ioannidis JP, Wheeler M, Maciewicz RA, van Meurs JB, Arden NK, Spector TD, Doherty M The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance. ANN RHEUM DIS. 2011 May;70(5):873-5. Epub 2010 Sep 24.
  14. Prieto-Alhambra D, Javaid MK, Judge A, Maskell J, Kiran A, de Vries F, Cooper C, Arden NK Fracture risk before and after total hip replacement in patients with osteoarthritis: potential benefits of bisphosphonate use. ARTHRITIS RHEUM-US. 2011 Apr;63(4):992-1001. doi: 10.1002/art.30214.
  15. Luqmani R, Suppiah R, Edwards CJ, Phillip R, Maskell J, Culliford D, Jayne D, Morishita K, Arden N Mortality in Wegener's granulomatosis: a bimodal pattern. RHEUMATOLOGY. 2011 Apr;50(4):697-702. Epub 2010 Nov 25.
  16. Williams FMK, Popham M, Hart DJ, de Schepper E, Bierma-Zeinstra S, Hofman A, Uitterlinden AG, Arden NK, Cooper C, Spector TD, Valdes AM, van Meurs J Gdf5 Single-Nucleotide Polymorphism Rs143383 Is Associated With Lumbar Disc Degeneration In Northern European Women ARTHRITIS RHEUM-US. 2011 Mar; 3(63): 708-712. doi: 10.1002/art.30169
  17. Williams F, Popham M, Hart D, de Schepper E, Bierma-Zeinstra S, Hofman A, Uitterlinden AG, Arden N, Cooper C, Spector T, Valdes A, van Meurs J GDF5 SNP rs143383 is associated with lumbar disc disease in northern European women. ARTHRITIS RHEUM-US. 2011 Mar;63(3):708-12. doi: 10.1002/art.30169.
  18. Kerkhof HJ, Doherty M, Arden NK, Abramson SB, Attur M, Bos SD, Cooper C, Dennison EM, Doherty SA, Evangelou E, Hart DJ, Hofman A, Javaid K, Kerna I, Kisand K, Kloppenburg M, Krasnokutsky S, Maciewicz RA, Meulenbelt I, Muir KR, Rivadeneira F, Samuels J, Sezgin M, Slagboom E, Smith AJ, Spector TD, Tamm A Large-Scale Meta-Analysis Of Interleukin-1 Beta And Interleukin-1 Receptor Antagonist Polymorphisms On Risk Of Radiographic Hip And Knee Osteoarthritis And Severity Of Knee Osteoarthritis Osteoarthritis Cartilage. 2011 Mar; 3(19): 265-271. doi: 10.1016/j.joca.2010.12.003
  19. Arden NK, Kiran A, Judge A, Biant LC, Javaid MK, Murray DW, Carr AJ, Cooper C, Field RE What is a good patient reported outcome after total hip replacement? OSTEOARTHR CARTILAGE. 2011 Feb;19(2):155-62. Epub 2010 Oct 15
  20. Prieto-Alhambra D, Javaid MK, Maskell J, Judge A, Nevitt M, Cooper C, Arden NK Changes in Hip Fracture Rate before and after total knee replacement due to Osteoarthritis: a population-based cohort study. ANN RHEUM DIS. 2011 Jan;70(1):134-8. Epub 2010 Oct 26.
  21. Southam L, Panoutsopoulou K, Rayner NW, Chapman K, Durrant C, Ferreira T, Arden N, Carr A, Deloukas P, Doherty M, Loughlin J, McCaskie A, Ollier WE, Ralston S, Spector TD, Valdes AM, Wallis GA, Wilkinson JM, Marchini J, Zeggini E The effect of genome-wide association scan quality control on imputation outcome for common variants. EUR J HUM GENET. 2011 May;19(5):610-614. Epub 2011 Jan 26.
  22. Hunter DJ, Arden N, Conaghan PG, Eckstein F, Gold G, Grainger A, Guermazi A, Harvey W, Jones G, Hellio Le Graverand MP, Laredo JD, Lo G, Losina E, Mosher TJ, Roemer F, Zhang W Definition Of Osteoarthritis On Mri: Results Of A Delphi Exercise Osteoarthritis and Cartilage. 2011; 8(19): 963-969
  23. Bolland BJRF, Culliford DJ, Maskell J, Latham JM, Dunlop DG, Arden NK The Effect Of Hip And Knee Arthroplasty On Oral Anti-Inflammatory Use And The Relationship To Body Mass Index: Results From The Uk General Practice Research Database Osteoarthritis and Cartilage. 2011; 1(19): 29-36
  24. Cooper C, Arden NK Excess Mortality In Osteoarthritis BMJ. 2011: d1407
  25. Bowen CJ, Culliford D, Allen R, Beacroft J, Gay A, Hooper L, Burridge J, Edwards CJ, Arden NK Forefoot Pathology In Rheumatoid Arthritis Identified With Ultrasound May Not Localise To Areas Of Highest Pressure: Cohort Observations At Baseline And Twelve Months J Foot Ankle Res. 2011; 1(4): 25. doi: 10.1186/1757-1146-4-25
  26. Bolland BJRF, Culliford DJ, Langton DJ, Millington JPS, Arden NK, Latham JM High Failure Rates With A Large-Diameter Hybrid Metal-On-Metal Total Hip Replacement: Clinical, Radiological And Retrieval Analysis Journal of Bone and Joint Surgery - Series B. 2011; 5(93 B): 608-615
  27. Valdes AM, De Wilde G, Doherty SA, Lories RJ, Vaughn FL, Laslett LL, Maciewicz RA, Soni A, Hart DJ, Zhang W, Muir KR, Dennison EM, Wheeler M, Leaverton P, Cooper C, Spector TD, Cicuttini FM, Chapman V, Jones G, Arden NK, Doherty M The Ile585Val Trpv1 Variant Is Involved In Risk Of Painful Knee Osteoarthritis Annals of the Rheumatic Diseases. 2011
  28. Lalmohamed A, Opdam F, Arden NK, Prieto-Alhambra D, van Staa T, Leufkens HGM, de Vries F Knee Arthroplasty And Risk Of Hip Fracture: A Population-Based, Case-Control Study Calcified Tissue International. 2011: 1-7

2010

  1. Bowen CJ, Hooper L, Culliford D, Dewbury K, Sampson M, Burridge J, Edwards CJ, Arden NK Assessment of the natural history of forefoot bursae using ultrasonography in patients with rheumatoid arthritis: a twelve-month investigation. ARTHRIT RHEUM-ARTHR. 2010 Dec;62(12):1756-62. doi: 10.1002/acr.20326.
  2. Panoutsopoulou K, Southam L, Elliott KS, Wrayner N, Zhai G, Beazley C, Thorleifsson G, Arden NK, Carr A, Chapman K, Deloukas P, Doherty M, McCaskie A, Ollier WE, Ralston SH, Spector TD, Valdes AM, Wallis GA, Wilkinson JM, Arden E, Battley K, Blackburn H, Blanco FJ, Bumpstead S, Cupples LA, Day-Williams AG, Dixon K, Doherty SA, Esko T, Evangelou E, Felson D, Gomez-Reino JJ, Gonzalez A, Gordon A, Gwilliam R, Halldorsson BV, Hauksson VB, Hofman A, Hunt SE, Ioannidis JP, Ingvarsson T, Jonsdottir I, Jonsson H, Keen R, Kerkhof HJ, Kloppenburg MG, Koller N, Lakenberg N, Lane NE, Lee AT, Metspalu A, Meulenbelt I, Nevitt MC, O'Neill F, Parimi N, Potter SC, Rego-Perez I, Riancho JA, Sherburn K, Slagboom PE, Stefansson K, Styrkarsdottir U, Sumillera M, Swift D, Thorsteinsdottir U, Tsezou A, Uitterlinden AG, van Meurs JB, Watkins B, Wheeler M, Mitchell S, Zhu Y, Zmuda JM, Zeggini E, Loughlin J Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study. ANN RHEUM DIS. 2010 Dec 21. [Epub ahead of print]
  3. Evangelou E, Valdes AM, Kerkhof HJ, Styrkarsdottir U, Zhu Y, Meulenbelt I, Lories RJ, Karassa FB, Tylzanowski P, Bos SD, Akune T, Arden NK, Carr A, Chapman K, Cupples LA, Dai J, Deloukas P, Doherty M, Doherty S, Engstrom G, Gonzalez A, Halldorsson BV, Hammond CL, Hart DJ, Helgadottir H, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Kaprio J, Kawaguchi H, Kisand K, Kloppenburg M, Kujala UM, Lohmander LS, Loughlin J, Luyten FP, Mabuchi A, McCaskie A, Nakajima M, Nilsson PM, Nishida N, Ollier WE, Panoutsopoulou K, van de Putte T, Ralston SH, Rivadeneira F, Saarela J, Schulte-Merker S, Shi D, Slagboom PE, Sudo A, Tamm A, Thorleifsson G, Thorsteinsdottir U, Tsezou A, Wallis GA, Wilkinson JM, Yoshimura N, Zeggini E, Zhai G, Zhang F, Jonsdottir I, Uitterlinden AG, Felson DT, van Meurs JB, Stefansson K, Ioannidis JP, Spector TD Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. ANN RHEUM DIS. 2010 Nov 10. [Epub ahead of print]
  4. Bridges JF, Taylor SD, Arden N, Hauber AB, Johnson FR, Watson D, Mavros P, Pellissier JM, Peloso P, Sen S, Mohamed A, Gonzalez JM Physicians' Stated Preferences Over Benefits And Risks Associated With Nsaid Use In Patients With Osteoarthritis In United Kingdom VALUE IN HEALTH. 2010 Nov; 7(13): A316
  5. Bridges JF, Taylor SD, Arden N, Hauber AB, Johnson FR, Watson D, Mavros P, Pellissier JM, Peloso P, Sen S, Mohamed A, Gonzalez JM Preferences Over Benefits And Risks Associated With The Use Of Nsaids: Evidence From Patients Diagnosed With Osteoarthritis (Oa) In Uk VALUE IN HEALTH. 2010 Nov; 7(13): A312
  6. Kerkhof HJ, Meulenbelt I, Akune T, Arden NK, Aromaa A, Bierma-Zeinstra SM, Carr A, Cooper C, Dai J, Doherty M, Doherty SA, Felson D, Gonzalez A, Gordon A, Harilainen A, Hart DJ, Hauksson VB, Heliovaaram M, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Jonsdottir I, Kawaguchi H, Kloppenburg M, Kujala UM, Lane NE, Leino-Arjas P, Lohmander LS, Luyten FP, Malizos KN, Nakajima M, Nevitt MC, Pols HA, Rivadeneira F, Shi D, Slagboom E, Spector TD, Stefansson K, Sudo A, Tamm A, Tamm AE, Tsezou A, Uchida A, Uitterlinden AG, Wilkinson JM, Yoshimura N, Valdes AM, van Meurs JB Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. OSTEOARTHR CARTILAGE. 2010 Nov 6. [Epub ahead of print]
  7. Roemer FW, Kassim Javaid M, Guermazi A, Thomas M, Kiran A, Keen R, King L, Arden NK Anatomical distribution of synovitis in knee osteoarthritis and its association with joint effusion assessed on non-enhanced and contrast-enhanced MRI. OSTEOARTHR CARTILAGE. 2010 Oct;18(10):1269-74. Epub 2010 Aug 5.
  8. Valdes AM, Arden NK, Vaughn FL, Doherty SA, Leaverton PE, Zhang W, Muir KR, Rampersaud E, Dennison EM, Edwards MH, Jameson KA, Javaid MK, Spector TD, Cooper C, Maciewicz RA, Doherty M Role of the Na(V)1.7 R1150W amino acid change in susceptibility to symptomatic knee osteoarthritis and multiple regional pain. ARTHRIT RHEUM-ARTHR. 2010 Oct 28. [Epub ahead of print]
  9. Ayis S, Arden N, Doherty M, Pollard B, Johnston M, Dieppe P Applying the impairment, activity limitation, and participation restriction constructs of the ICF model to osteoarthritis and low back pain trials: a reanalysis. J RHEUMATOL. 2010 Sep;37(9):1923-31. Epub 2010 Jul 1.
  10. Valdes AM, McWilliams D, Arden NK, Doherty SA, Wheeler M, Muir KR, Zhang W, Cooper C, Maciewicz RA, Doherty M Involvement of different risk factors in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes. ARTHRITIS RHEUM-US. 2010 Sep;62(9):2688-95.
  11. Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, Kiel DP, Streeten EA, Ohlsson C, Koller DL, Peltonen L, Cooper JD, O'Reilly PF, Houston DK, Glazer NL, Vandenput L, Peacock M, Shi J, Rivadeneira F, McCarthy MI, Anneli P, de Boer IH, Mangino M, Kato B, Smyth DJ, Booth SL, Jacques PF, Burke GL, Goodarzi M, Cheung CL, Wolf M, Rice K, Goltzman D, Hidiroglou N, Ladouceur M, Wareham NJ, Hocking LJ, Hart D, Arden NK, Cooper C, Malik S, Fraser WD, Hartikainen AL, Zhai G, Macdonald HM, Forouhi NG, Loos RJ, Reid DM, Hakim A, Dennison E, Liu Y, Power C, Stevens HE, Jaana L, Vasan RS, Soranzo N, Bojunga J, Psaty BM, Lorentzon M, Foroud T, Harris TB, Hofman A, Jansson JO, Cauley JA, Uitterlinden AG, Gibson Q, Järvelin MR, Karasik D, Siscovick DS, Econs MJ, Kritchevsky SB, Florez JC, Todd JA, Dupuis J, Hyppönen E, Spector TD Common genetic determinants of vitamin D insufficiency: a genome-wide association study. LANCET. 2010 Jul 17;376(9736):180-8. Epub 2010 Jun 10.
  12. Prieto-Alhambra D, Javaid MK, Servitja S, Arden NK, Martinez-García M, Diez-Perez A, Albanell J, Tusquets I, Nogues X Vitamin D threshold to prevent aromatase inhibitor-induced arthralgia: a prospective cohort study. BREAST CANCER RES TR. 2010 Jul 28. [Epub ahead of print]
  13. Bowen CJ, Edwards CJ, Hooper L, Dewbury K, Sampson M, Sawyer S, Burridge J, Arden NK Improvement in symptoms and signs in the forefoot of Patients With Rheumatoid Arthritis treated with Anti-TNF Therapy. J Foot Ankle Res. 2010 Jun 17;3:10.
  14. Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Streeten EA, Ohlsson C, Berry D, Florez J, Koller DL, Jarvelin MR, Cooper JD, O'Reilly P, Glazer NL, Vandenput L, Peacock M, Houston DK, Shi JS, Rivadeneira F, McCarthy M, Anneli P, de Boer IH, Mangino M, Kato B, Smyth DJ, Booth SL, Jacques PF, Burke GL, Goodarzi M, Cheung CL, Wolf M, Rice K, Goltzman D, Hiridigolou N, Ladouceur M, Hui SL, Wareham NJ, Hocking LJ, Hart D, Arden NK, Cooper C, Zhai G, Macdonald H, Forouhi NG, Loos RJF, Reid DM, Hakim A, Dennison E, Liu Y, Power C, Stevens H, Jaana L, Vasan RS, Soranzo N, Bojunga J, Psaty BM, Lorentzon M, Foroud T, Harris TB, Hofman A, Karasik D, Jansson JO, Uitterlinden AG, Cauley JA, Gibson Q, Palotie L, Siscovick DS, Kiel D, Econs MJ, Kritchevsky SB, Hypponen E, Dupuis J, Todd JA, Spector TD Identification of genetic susceptibility loci for vitamin D insufficiency: the SUNLIGHT consortium LANCET. In press
  15. Valdes AM, Arden NK, Tamm A, Kisand K, Doherty S, Pola E, Cooper C, Muir KR, Kerna I, Hart D, O'Neil F, Zhang W, Spector TD, Maciewicz RA, Doherty M A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis. OSTEOARTHR CARTILAGE. 2010 May;18(5):699-704. Epub 2010 Feb 6.
  16. White KM, Chumley A, Petley GW, Edwards CJ, Taylor P, Mays S, Sofaer J, Mahon P, Cooper C, Arden NK Changes in proximal hip geometry between medieval and modern Britons. CALCIFIED TISSUE INT. Manuscript submitted and accepted
  17. Harvey N, Mahon P, Robinson S, Nisbet C, Javaid M, Crozier S, Inskip H, Godfrey K, Arden N, Dennison E, Cooper C Different Indices of Fetal Growth Predict Bone Size and Volumetric Density at 4 Years Old. J BONE MINER RES. 2010 Apr;25(4):920-927.
  18. Valdes AM, Spector TD, Tamm A, Kisand K, Doherty SA, Dennison EM, Mangino M, Kerna I, Hart DJ, Wheeler M, Cooper C, Lories RJ, Arden NK, Doherty M Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. ARTHRITIS RHEUM-US. 2010 Apr 21. [Epub ahead of print]
  19. Zhang W, Nuki G, Moskowitz RW, Abramson S, Altman RD, Arden NK, Bierma-Zeinstra S, Brandt KD, Croft P, Doherty M, Dougados M, Hochberg M, Hunter DJ, Kwoh K, Lohmander LS, Tugwell P OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009. OSTEOARTHR CARTILAGE. 2010 Apr;18(4):476-99. Epub 2010 Feb 11. Review.
  20. Zhai G, Wang-Sattler R, Hart DJ, Arden NK, Hakim AJ, Illig T, Spector TD Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis. ANN RHEUM DIS. 2010 Apr 13. [Epub ahead of print]
  21. Zhang W, Doherty M, Peat G, Bierma-Zeinstra MA, Arden NK, Bresnihan B, Herrero-Beaumont G, Kirschner S, Leeb BF, Lohmander LS, Mazieres B, Pavelka K, Punzi L, So AK, Tuncer T, Watt I, Bijlsma JW EULAR evidence-based recommendations for the diagnosis of knee osteoarthritis. ANN RHEUM DIS. 2010 Mar;69(3):483-9. Epub 2009 Sep 17.
  22. Price AJ, Longino D, Rees J, Rout R, Pandit H, Javaid K, Arden N, Cooper C, Carr AJ, Dodd CA, Murray DW, Beard DJ Are pain and function better measures of outcome than revision rates after TKR in the younger patient? KNEE. 2010 Jun;17(3):196-9. Epub 2010 Feb 4.
  23. Harvey NC, Javaid MK, Arden NK, Poole JR, Crozier SR, Robinson SM, Inskip HM, Godfrey KM, Dennison EM, Cooper C, Team SWSS Maternal Predictors Of Neonatal Bone Size And Geometry: The Southampton Women'S Survey JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE. 2010 Feb; 1(1): 35-41. doi: 10.1017/S2040174409990055
  24. Bowen CJ, Culliford D, Dewbury K, Sampson M, Burridge J, Hooper L, Edwards CJ, Arden NK The clinical importance of ultrasound detectable forefoot bursae in rheumatoid arthritis. RHEUMATOLOGY. 2010 Jan;49(1):191-2. Epub 2009 Sep 30.
  25. Culliford DJ, Maskell J, Beard DJ, Murray DW, Price AJ, Arden NK Temporal trends in hip and knee replacement in the United Kingdom: 1991 to 2006. J BONE JOINT SURG BR. 2010 Jan;92(1):130-5.

2009

  1. Javaid MK, Lane NE, Mackey DC, Lui LY, Arden NK, Beck TJ, Hochberg MC, Nevitt MC Changes in proximal femoral mineral geometry precede the onset of radiographic hip osteoarthritis: The study of osteoporotic fractures. ARTHRITIS RHEUM-US. 2009 Jul;60(7):2028-36
  2. Mahon P, Harvey N, Crozier S, Inskip H, Robinson S, Arden N, Swaminathan R, Cooper C, Godfrey K Low Maternal Vitamin D Status and Fetal Bone Development: Cohort Study. J BONE MINER RES. 2009 Jul 6. [Epub ahead of print]
  3. Luqmani R, Edwards C, Culliford D, Maskell J, Arden N Bimodal Mortality Risk In Wegener's Granulomatosis APMIS. 2009 Jun: 160
  4. Arden NK, Lane NE, Parimi N, Javaid KM, Lui LY, Hochberg MC, Nevitt M Defining Incident Radiographic Hip Osteoarthritis for Epidemiologic Studies in Women. ARTHRITIS RHEUM-US. 2009 Apr;60(4):1052-9.
  5. Abdin-Mohamed M, Jameson K, Dennison EM, Cooper C, Arden NK Volumetric bone mineral density of the tibia is not increased in subjects with radiographic knee osteoarthritis. OSTEOARTHR CARTILAGE. 2009 Feb;17(2):174-7. Epub 2008 Aug 5.
  6. Colebatch AN, Hart DJ, Zhai G, Williams FM, Spector TD, Arden NK Effective measurement of knee alignment using AP knee radiographs. KNEE. 2009 Jan;16(1):42-5. Epub 2008 Sep 14.
  7. Zhang W, Doherty M, Leeb BF, Alekseeva L, Arden NK, Bijlsma JW, Dincer F, Dziedzic K, Hauselmann HJ, Kaklamanis P, Kloppenburg M, Lohmander LS, Maheu E, Martin-Mola E, Pavelka K, Punzi L, Reiter S, Smolen J, Verbruggen G, Watt I, Zimmermann-Gorska I EULAR evidence-based recommendations for the diagnosis of hand osteoarthritis: report of a task force of ESCISIT. ANN RHEUM DIS. 2009 Jan;68(1):8-17. Epub 2008 Feb 4. Review.
  8. Harvey N, Javaid M, Arden N, Poole J, Crozier S, Robinson S, Inskip H, Godfrey K, Dennison E, Cooper C Maternal determinants of intrauterine bone mineral accrual: The Southampton Women's Survey J DOHaD. 2009 (in press)