Dr Philippa A Hulley
BSc Med (Hons), PhD
Arthritis Research Campaign and RCUK Fellow
University Research Lecturer
Group Head: Cell signaling in skeletal regeneration
Email: philippa.hulley@ndorms.ox.ac.uk
Dr Hulley studied pattern formation during a developmental biology PhD at the University of Cape Town, South Africa, and followed this with post-doctoral work on cell signal transduction pathways in the Basel Preclinical Research Laboratories of Sandoz Pharma AG. She joined the University of Stellenbosch, South Africa, as a Senior Scientist/Lecturer in 1996, and focused on mapping the changes in normal osteoblast signalling that are produced by clinical doses of glucocorticoids and which cause steroid osteoporosis. Moving to Oxford, Dr Hulley was awarded a 5 year arc Fellowship in 2004, followed in 2007 by an RCUK Fellowship. She is a University Research Lecturer, teaching at St Hilda's College where she holds an Academic Fellowship.
Dr Hulley's work in Oxford is based on exploring survival and differentiation control pathways in skeletal cells. Research is directed towards understanding disease pathology and devising effective regenerative strategies.
Key Collaborators:
See the article, University of Oxford: Strong foundations for basic research, published by arc in March 2009 for further information about Dr Hulley's work and collaboration with Mr Price.
Publications
View all publications.
2009
- Alsousou J, Thompson M, Hulley P, Noble A, Willett K. The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature. J Bone Joint Surg Br. 2009 Aug;91(8):987-96. Review.
2008
- Xia Z, Murray D, Hulley PA, Triffitt JT, Price AJ. The viability and proliferation of human chondrocytes following cryopreservation. J Bone Joint Surg Br. 2008 Sep;90(9):1245-8.
- Liang M, Russell RG, Hulley PA. Bim, Bak, and Bax regulate osteoblast survival. J Bone Miner Res. 2008 May;23(5):610-20.
- Liu CZ, Xia ZD, Han ZW, Hulley PA, Triffitt JT, Czernuszka JT. Novel 3D collagen scaffolds fabricated by indirect printing technique for tissue engineering. J Biomed Mater Res B Appl Biomater. 2008 May;85(2):519-28.
- Espina B, Liang M, Russell RG, Hulley PA. Regulation of Bim in glucocorticoid-mediated osteoblast apoptosis. J Cell Physiol. 215: 488-96; Epub 2007 Dec 6.
2007
- Horsch K, de Wet H, Schuurmans MM, Allie-Reid F, Cato AC, Cunningham J, Burrin JM, Hough FS, Hulley PA. Mitogen-activated protein kinase phosphatase 1/dual specificity phosphatase 1 mediates glucocorticoid inhibition of osteoblast proliferation. Mol Endocrinol. 2007 Dec;21(12):2929-40. Epub 2007 Aug 30.
- Locklin RM, Federici E, Espina B, Hulley PA, Russell RG, Edwards CM. Selective targeting of death receptor 5 circumvents resistance of MG-63 osteosarcoma cells to TRAIL-induced apoptosis. Mol Cancer Ther. 6: 3219-28; Epub 2007 Dec 7.
- Roelofs AJ, Edwards CM, Russell RG, Ebetino FH, Rogers MJ, Hulley PA. Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Pharmacol Exp Ther. 322(1):228-35.
- Russell RG, Xia Z, Dunford JE, Oppermann U, Kwaasi A, Hulley PA, Kavanagh KL, Triffitt JT, Lundy MW, Phipps RJ, Barnett BL, Coxon FP, Rogers MJ, Watts NB, Ebetino FH. Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy. Ann N Y Acad Sci. 1117: 209-57.
- Conradie MM, de Wet H, Kotze DDJ, Burrin JM, Hough FS, Hulley PA. Vanadate prevents glucocorticoid-induced apoptosis of osteoblasts in vitro and osteocytes in vivo. Journal of Endocrinology
2006
- Russell RG, Espina B, Hulley P. Bone biology and the pathogenesis of osteoporosis. Curr Opin Rheumatology 18 Suppl 1:S3-10.
- Roelofs AJ, Hulley PA, Meijer A, Ebetino FH, Russell RG, Shipman CM. Selective inhibition of Rab prenylation by a phosphonocarboxylate analogue of risedronate induces apoptosis, but not S-phase arrest, in human myeloma cells. International Journal of Cancer 119(6):1254-61.