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Immunohistochemical studies have confirmed the innervation of bone with neuropeptidergic neurons containing vasoactive intestinal polypeptide (VIP), substance P (SP) and calcitonin gene-related peptide (CGRP). In this study, we report effects of VIP on connective tissue cell metabolism. VIP stimulated PGE2 production in human articular chondrocytes, human osteoblast-like cells and human synovial cells, however, stromelysin production was unaffected. VIP also stimulated cAMP production in human osteoblast-like cells, but not in human articular chondrocytes or synovial cells. These findings are suggestive of a role of VIP in connective tissue cell metabolism which may contribute to the inflammatory processes of arthritis.

Original publication

DOI

10.1016/0167-0115(92)90660-m

Type

Journal article

Journal

Regul pept

Publication Date

23/01/1992

Volume

37

Pages

111 - 121

Keywords

Cartilage, Articular, Connective Tissue, Cyclic AMP, Dinoprostone, Humans, In Vitro Techniques, Matrix Metalloproteinase 3, Metalloendopeptidases, Osteoblasts, Peptide Hydrolases, Synovial Membrane, Vasoactive Intestinal Peptide