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We characterized the presence and localization of bone morphogenetic protein 4 (BMP-4) mRNA in the regenerating tissues produced by distraction osteogenesis following tibial osteotomy in the rabbit. The findings are consistent with previous reports on the localization of BMP-4 mRNA expression during fracture repair. The BMP-4 gene is expressed by less differentiated osteoprogenitor cells (fibroblastic mesenchymal cells and preosteoblasts), and not by fully differentiated osteoblasts. BMP-4 gene expression is localized in callus-forming tissue (muscle, periosteum) during callus formation. Our observations suggest that the BMP-4 gene product is one of the local contributing factors in regulating bone and cartilage formation in distraction osteogenesis.

Type

Journal article

Journal

Acta orthop scand

Publication Date

08/1998

Volume

69

Pages

420 - 425

Keywords

Animals, Blotting, Northern, Bone Morphogenetic Protein 4, Bone Morphogenetic Proteins, Bone Regeneration, Disease Models, Animal, Gene Expression, Humans, In Situ Hybridization, Osteoblasts, Osteogenesis, Osteogenesis, Distraction, RNA, Messenger, Rabbits, Tibia