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A through-knee amputation for suspected osteogenic sarcoma was performed on a patient with Paget's disease of the tibia. Plasma alkaline phosphatase (AP) activity fell to normal values, apparently as a single exponential function of time, with a half-life of 1.7 days. The daily turnover of bone-derived plasma AP was estimated to be approximately 200 I.U. from the Pagetic tibia and 20 I.U. from the rest of the skeleton.

Original publication

DOI

10.1016/0009-8981(75)90167-9

Type

Journal article

Journal

Clin chim acta

Publication Date

01/09/1975

Volume

63

Pages

227 - 229

Keywords

Alkaline Phosphatase, Bone and Bones, Half-Life, Humans, Male, Middle Aged, Osteitis Deformans, Tibia