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SUMMARY: Fine-mapping human leukocyte antigen (HLA) genes involved in disease susceptibility to individual alleles or amino acid residues has been challenging. Using information regarding HLA alleles obtained from HLA typing, HLA imputation or HLA inference, our software expands the alleles to amino acid sequences using the most recent IMGT/HLA database and prepares a dataset suitable for fine-mapping analysis. Our software also provides useful functionalities, such as various association tests, visualization tools and nomenclature conversion. AVAILABILITY AND IMPLEMENTATION: https://github.com/WansonChoi/HATK.

Original publication

DOI

10.1093/bioinformatics/btaa684

Type

Journal article

Journal

Bioinformatics

Publication Date

20/04/2021

Volume

37

Pages

416 - 418

Keywords

Alleles, Amino Acid Sequence, Chromosome Mapping, Genetic Predisposition to Disease, HLA Antigens, Histocompatibility Testing, Humans, Software