The relationship between disturbed metabolism of vitamin D and bone disease in chronic renal failure.
Kanis JA., Russell RG., Taylor CM., Cundy T., Andrade A., Heynen G.
Following the discovery that the kidney is involved in the metabolism of vitamin D, a causal relationship has been sought between defective production of 1,25-dihydroxy vitamin D3 and bone disease in chronic renal failure. This paper reviews some of the clinical evidence for and against such a relationship, and considers the possible role of other vitamin D metabolites in the pathophysiology of renal bone disease.