3D printed reactor-in-a-centrifuge (RIAC): A novel approach to the production of organic nanomaterials
Cristaldi DA., Labanca A., Owen J., Stulz E., Zhang X., Carugo D.
Copyright © (2018) by Chemical and Biological Microsystems Society. All rights reserved. The development of a technique to synthetise drug delivery vehicles on-demand, at high-throughput and low-cost, still remains a considerable challenge. In this study, we introduce a cost-effective and facile method for producing organic nanomaterials, based on a pump-free 3D printed reactor-in-a-centrifuge (RIAC). A RIAC device can be manufactured using a fused deposition modeling (FDM) desk 3D printer, within 4-6 hours from design and at a material cost of ∼$1. Moreover, devices only require an ordinary centrifuge to be operated. Here, we discuss design iterations and physico-chemical conditions to obtain controlled-size liposomes having a diameter <200 nm.