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Parvovirus 4 (PARV4) is a DNA virus frequently associated with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections, but its clinical significance is unknown. We studied the prevalence of PARV4 antibodies in 2 cohorts of HIV- and HCV-infected individuals (n = 469) and the correlations with disease status. We found that PARV4 infection frequently occurred in individuals exposed to bloodborne viruses (95% in HCV-HIV coinfected intravenous drug users [IDUs]). There were no correlations between PARV4 serostatus and HCV outcomes. There was, however, a significant association with early HIV-related symptoms, although because this was tightly linked to both HCV status and clinical group (IDU), the specific role of PARV4 is not yet clear.

Original publication

DOI

10.1093/infdis/jis291

Type

Journal article

Journal

J infect dis

Publication Date

15/06/2012

Volume

205

Pages

1816 - 1820

Keywords

Antibodies, Viral, Female, HIV Infections, Hepatitis C, Humans, Male, Parvoviridae Infections, Seroepidemiologic Studies