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This study investigates the clinical, radiological, and pathological features of two cases of intraosseous schwannoma that arose in patients with multiple soft tissue schwannomas. In both cases, the patients were adult females and the tibial bone was affected. Vestibular schwannomas were not identified, indicating that these were not cases of neurofibromatosis 2 (NF2). Radiographs showed a well-defined lytic lesion in the proximal tibia; in one case, this was associated with a pathological fracture. Histologically, both cases showed typical features of benign schwannoma. Molecular analysis of one of the excised tumors showed different alterations in the NF2 gene in keeping with a diagnosis of schwannomatosis. Our findings show for the first time that intraosseous schwannomas can occur in schwannomatosis.

Original publication

DOI

10.1007/s00256-013-1712-6

Type

Journal article

Journal

Skeletal radiol

Publication Date

12/2013

Volume

42

Pages

1665 - 1671

Keywords

Bone Neoplasms, Diagnosis, Differential, Female, Humans, Middle Aged, Neurilemmoma, Neurofibromatoses, Radiography, Skin Neoplasms, Tibia, Treatment Outcome