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Mechanical stimuli are important signals in articular cartilage, but what mediates them is unknown. We have shown that extracellular-signal-regulated kinase was activated on cutting and loading articular cartilage, and deduced that this was due to the release of bFGF (basic fibroblast growth factor) from the tissue. bFGF was shown to be extracellular, and by immunohistochemistry, was present in the pericellular matrix of articular chondrocytes attached to the heparan sulphate proteoglycan perlecan. We propose a novel mechanotransduction model, whereby pericellular bFGF, a short distance from the cell surface, becomes available to the cell surface tyrosine kinase receptors when articular cartilage is loaded.

Original publication

DOI

10.1042/BST0340456

Type

Journal article

Journal

Biochem soc trans

Publication Date

06/2006

Volume

34

Pages

456 - 457

Keywords

Animals, Cartilage, Articular, Fibroblast Growth Factor 2, Humans, Mechanotransduction, Cellular