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Genomic triplication of the alpha-synuclein gene (SNCA) has been reported to cause hereditary early-onset parkinsonism with dementia. These findings prompted us to screen for multiplication of the SNCA locus in nine families in whom parkinsonism segregates as an autosomal dominant trait. One kindred was identified with SNCA duplication by semiquantitative PCR and confirmed by fluorescent in-situ hybridisation analysis in peripheral leucocytes. By contrast with SNCA triplication families, the clinical phenotype of SNCA duplication closely resembles idiopathic Parkinson's disease, which has a late age-of-onset, progresses slowly, and in which neither cognitive decline nor dementia are prominent. These findings suggest a direct relation between SNCA gene dosage and disease progression.

Original publication

DOI

10.1016/S0140-6736(04)17103-1

Type

Journal article

Journal

Lancet

Publication Date

25/09/2004

Volume

364

Pages

1167 - 1169

Keywords

Adult, Age of Onset, Aged, Aged, 80 and over, Female, Gene Dosage, Gene Duplication, Humans, In Situ Hybridization, Fluorescence, Lewy Body Disease, Male, Microsatellite Repeats, Middle Aged, Mutation, Missense, Nerve Tissue Proteins, Parkinson Disease, Polymerase Chain Reaction, Synucleins, alpha-Synuclein