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Kennedy Trust Prize Studentships

  • Project No: KTPS-NC-18
  • Intake: 2021 KTPS-NC

About the Project

Inflammatory bowel diseases (IBD) are chronic and debilitating conditions affecting over 5M people worldwide. They arise due a breakdown in the dialogue between the immune system and the intestinal microbiome, leading to aberrant inflammation. The gut microbiome itself is critical in maintaining a homeostatic balance via production of important immunomodulatory metabolites such as short chain fatty acids (SCFAs). In IBD, the composition of the microbiota is compromised, leading to reduced levels of these key metabolites. Using synthetic microbiomes, gnotobiotic technology and engineered microbes this project seeks to harness the microbiome to treat and prevent intestinal inflammation.

Using a series of in vitro and in vivo approaches, this project will explore the potential of microbial metabolites to manipulate immune cell function and treat disease in mouse models of inflammation. Studies of  human mononuclear  phagocyte function will complement mouse models.

Training opportunities

This project offers exposure to cutting edge technologies encompassing genomics, immunology, metabolism  and microbiome sciences. For more information please see our websites: Powrie Group and Holm Uhlig Group.  

 References

  1. Mukhopadhyay S, Heinz E, Porreca I, Alasoo K, Yeung A, Yang HT, Schwerd T, Forbester JL, Hale C, Agu CA, Choi YH, Rodrigues J, Capitani M, Jostins-Dean L, Thomas DC, Travis S, Gaffney D, Skarnes WC, Thomson N, Uhlig HH, Dougan G, Powrie F. Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2. J Exp Med. 2020 Feb 3;217(2):e20180649.
  2. Schulthess J, Pandey S, Capitani M, Rue-Albrecht KC, Arnold I, Franchini F, Chomka A, Ilott NE, Johnston DGW, Pires E, McCullagh J, Sansom SN, Arancibia-Cárcamo CV, Uhlig HH, Powrie F. 2019 The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages. Immunity 50(2):432-445.e7
  3.  Danne C, Ryzhakov G, Martinez-Lopez M, Ilott NE, Franchini F, Cuskin F, Lowe EC, Bullers SJ, Arthur JSC, Powrie F. 2017. A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages. Cell Host Microbe 22: 733-45 e5
  4. Ilott NE, Bollrath J, Danne C, Schiering C, Shale M, Adelmann K, Krausgruber T, Heger A, Sims D, Powrie F. 2016. Defining the microbial transcriptional response to colitis through integrated host and microbiome profiling. ISME J 10: 2389-404

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