Professor Bowness and Dr Chen work on the immunology of Spondyloarthritis (SpA). SpA includes ankylosing spondylitis and psoriatic arthritis, which are common types of inflammatory arthritis. Prof Bowness leads the Immunology of Ankylosing Spondylitis group (currently 6 members).
Your primary role will be to analyse patient-derived data (including scRNA-seq data, immune phenotypes and other data) from patients enrolled into BRC AS cohorts and also the CARTOGRAPHY Rheumatology workstream. You will also assist with sample collection, PBMC and SFMC and synovial tissue sample preparation and isolation of specific cell types including lymphocytes monocytes, and stromal cells.
You will adapt, optimize, and compare existing next-generation sequencing methods and develop new laboratory methods and experimental protocols for tissue processing. In addition you will collaborate in the preparation of scientific reports and journal articles and present papers and posters.
You will have a PhD or equivalent in a medical or biologically-related disciplines (or be near to completion) and a BSc in a biology-relevant field. You will also have proven experience of human tissue digestion and cell isolations to high purity as well as extensive experience of analysis of scRNA-seq dataset analysis and proven understanding and experience in the fields of genomics, data processing and/or high-throughput data analysis. Proven understanding and experience in the fields of genomics, data processing and/or high-throughput data analysis is also essential. Experience of working with musculoskeletal tissues, particularly synovium is desirable.
This is a full-time role, with the flexibility for the post holder to work part time at minimum 0.5 FTE. The post is fixed term for 6 months.
The closing date for this position is midday on Friday 26 May 2023. Interviews are expected to be held on Tuesday 6 June 2023.
You will be required to upload a supporting statement as part of your online application.