Current preclinical models fail to capture the mechanics of oligodendrocyte myelination. Lasli et al. now demonstrate that the mechanical compliance of the axonal niche is a key determinant of oligodendrocyte maturation. By developing a platform that mimics the extreme mechanical softness of the central nervous system, they reveal myelination as a mechanically gated process as much as a biochemically regulated one.
Journal article
2026-04-28T00:00:00+00:00
9