The aim of this study is to explore what the UK public think about sharing their health data to develop and test artificial intelligence (AI).
\n \n\n \n \nThe Translational Pharmacology group focuses on the use of human experimental medicine studies to achieve scientific insight for patient benefit.
\n \n\n \n \nWith rapidly ageing populations in Asia, the number of patients at risk of hip fractures is increasing. Can a multidisciplinary training and support package ('HIPCARE') improve quality of life and reduce healthcare costs for patients with hip fracture?
\n \n\n \n \nWith rapidly ageing populations in Asia, the number of patients at risk of hip fractures is increasing. Can a multidisciplinary training and support package ('HIPCARE') improve quality of life and reduce healthcare costs for patients with hip fracture?
\n \n\n \n \nA multi-centre prospective randomised superiority trial of conservative versus surgical treatment for displaced distal tibial fractures in children aged 8-15 years.
\n \n\n \n \nThe clinical and cost-effectiveness of lumbar fusion surgery for patients with persistent, severe low back pain: Short: FusiOn veRsus bEst coNServatIve Care.
\n \n\n \n \nOur research aims to elucidate the role of peripheral glial cells in tissue health and disease.
\n \n\n \n \nThe Big BOSS Study- The British Orthopaedic Slipped Capital Femoral Epiphysis (SCFE) Surgery Study for Severe Stable Slips.\r\nA multi-centre prospective randomised superiority trial of an acute deformity correction versus pinning in-situ for severe stable SCFE in children.
\n \n\n \n \nOsteoporosis is a common bone disease that causes weaker bones that break after a fall and lead to chronic severe pain and life-changing complications. There are treatments available that strengthen bones and lower the chance of another fracture. Many hospitals have specialist teams dedicated to finding patients who have broken a bone to prevent the next fracture. We know breaking a bone in the spine, a spine fracture, is a critical sign of osteoporosis. However, most patients don't realise they have a spine fracture as they cause temporary back pain that is often ignored. We know that over three million people have scans that include the spine, for other reasons such as lung or bowel problems. Up to 1 in 20 scans could be showing there is a spine fracture. Currently, very few fractures are recognised or acted upon.\r\n\r\nThis project will use an innovative Artificial Intelligence (AI) software that automatically looks at existing CT scans to find these spine fractures and brings them directly to the specialist team's attention, to see if the patient needs bone-strengthening lifestyle advice and medicines. We call this an 'AI-enabled spine fracture pathway'. We will show that using the pathway will improve patient health and reduce costs to hospitals using multiple methods.
\n \n\n \n \nCreating a global atlas of the musculoskeletal system
\n \n\n \n \nCreating a global atlas of the musculoskeletal system
\n \n\n \n \nClinical effectiveness of an adolescent-specific strengthening programme, compared to usual care, for ambulant adolescents with spastic cerebral palsy (ROBUST trial): a parallel group randomised controlled trial.
\n \n\n \n \nClinical effectiveness of a child-specific dynamic stretching programme, compared to usual care, for ambulant children with spastic cerebral palsy (SPELL trial): a parallel group randomised controlled trial.
\n \n\n \n \nOur research aims to improve people's health and wellbeing by making the most efficient use of health and social care resources. To achieve this, we use real-world data and mathematical models to evaluate the costs and consequences of applying different interventions over a period of time, often the entire lifetime of patients.
\n \n\n \n \nGenicular Artery Embolisation for the symptomatic treatment of knee osteoarthritis refractory to conservative management
\n \n\n \n \nProspective randomised controlled trial comparing endoscopic decompression of the ulnar nerve at the cubital tunnel with open surgery.
\n \n\n \n \nWe develop statistical methods and computational software to better understand the genetic contribution to immune-mediated traits.
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