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NEOPANC-01 is a window of opportunity study looking to assess gene expression in patients with resectable pancreatic cancer. It aims to evaluate the utility of whole transcriptome RNA sequencing as a potential biomarker for future window-of-opportunity trials that will assess existing and/or new treatments for pancreatic cancer. An understanding of the variability in the transcriptomic signature between biopsies will also inform power calculations for future studies. Lastly, the data generated will be available for use as historical controls for future studies. 2 sets of biopsy samples will be taken throughout the trial. Firstly during an endoscopic ultrasound procedure and then again, up to 6 weeks later, during the patients surgery to remove the cancer. Once all patients have been recruited, the mRNA from the samples will be sequenced and analysed. Further samples will also be taken at the same time points for storage into a biobank and for use in future research. This is a single site study opening at the Churchill Hospital looking to recruit 10 patients over 18 months.
FORENSIC
OCTRU SITU
The clinical and cost-effectiveness of lumbar fusion surgery for patients with persistent, severe low back pain: Short: FusiOn veRsus bEst coNServatIve Care.
ROBUST
OCTRU RRIO SITU
Clinical effectiveness of an adolescent-specific strengthening programme, compared to usual care, for ambulant adolescents with spastic cerebral palsy (ROBUST trial): a parallel group randomised controlled trial.
SPELL
OCTRU RRIO SITU
Clinical effectiveness of a child-specific dynamic stretching programme, compared to usual care, for ambulant children with spastic cerebral palsy (SPELL trial): a parallel group randomised controlled trial.
GEKO
OCTRU SITU
Genicular Artery Embolisation for the symptomatic treatment of knee osteoarthritis refractory to conservative management
DRAFT3 – CASP
Botnar OCTRU
This trial aims to compare two treatment methods that are currently standard care for treating wrist fractures. There are a large number of wrist fractures every year in the UK and by comparing the clinical and cost effectiveness of the treatments, this could help save money for the NHS.
OPTIMISE
OCTRU
Optimising Psoriatic Arthritis Therapy with Immunological Methods to Increase Standard Evaluation
PASHiOn
OCTRU SITU
Personalised Against Standard High tibial Osteotomy, a prospective multi-centre randomised controlled trial study
WISE
OCTRU Oxford Trauma
Progressive resistance and flexibility exercises versus usual care advice for improving pain and function after distal radius fracture in adults aged 50 years or over: the WISE randomised superiority trial
FRUITI
OCTRU Oxford Trauma
World Hip Trauma Evaluation - FRUITI: Fix or Replace Undisplaced Intracapsular fractures Trial of Interventions
PART
OCTRU SITU
A randomised controlled trial of Partial prostate Ablation versus Radical Treatment in intermediate risk, unilateral clinically localised prostate cancer
CRAFFT
OCTRU Oxford Trauma
Children’s Radius Acute Fracture Fixation Trial. A multi-centre prospective randomized non- inferiority trial of surgical reduction versus non-surgical casting for displaced distal radius fractures in children.
GRRAND-F
OCTRU RRIO
ACL SNNAP
Botnar OCTRU SITU
Comparison of the clinical and cost effectiveness of two management strategies for non-acute Anterior Cruciate Ligament (ACL) injury: rehabilitation versus surgical reconstruction