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The latest updates on our research and how it is improving people’s quality of life.

Targeting tendinopathy resolution

Targeting tendinopathy resolution

Publication Research Inflammation biology

In a new study published in journal Scientific Reports, scientists at NDORMS and Queen Mary University of London have identified reasons underpinning the failure of inflammation to resolve in disorders of musculoskeletal soft tissues such as tendons.

Dopamine rewards immune cells through immunological synapse

Dopamine rewards immune cells through immunological synapse

Research Immunity and microbiome Publication

Researchers at the Kennedy Institute of Rheumatology at the University of Oxford mapped dopamine and the consequences of its release to the immunological synapse.

Supporting patient safety through best-practice trial design

Supporting patient safety through best-practice trial design

Publication Research CSM Statistics and epidemiology

UK statisticians and trialists reach out to the clinical trial community in an awareness-raising paper published this week as a first step in changing practice. They promote the use of adaptive designs in early-phase clinical trials to improve trial efficiency, which will benefit patients.

Link between patient age and risk of revision

Link between patient age and risk of revision

Research Publication Botnar Orthopaedics, tissue engineering and regenerative medicine

Evidence released in the Lancet demonstrates a link between patient age and risk of revision on knee and hip replacements.

New potential treatment target for patients with inflammatory bowel disease

New potential treatment target for patients with inflammatory bowel disease

Publication Research Kennedy

A new study published today in Nature Medicine could change the lives of millions of people living with inflammatory bowel diseases (IBD) who don’t respond to the current standard of care.

Study offers hope of new treatment for rheumatoid arthritis

Study offers hope of new treatment for rheumatoid arthritis

Research Botnar Publication

Patients who do not respond to current rheumatoid arthritis (RA) treatments may benefit from a new form of treatment that has been shown in a study to be effective against symptoms of the disease.

Better diagnosis for back pain

Better diagnosis for back pain

Publication Awards

Research by Professor Jeremy Fairbank and colleagues, and published in the European Spine Journal, has found automation can improve how we diagnose back problems.

Elderly patients with unstable ankle fractures could avoid surgery

Elderly patients with unstable ankle fractures could avoid surgery

Publication Research

Elderly patients with unstable ankle fractures could avoid surgery, according to research by a UK team led by NDORMS at the Oxford University.

Getting it 'just right' in the immune system

Getting it 'just right' in the immune system

Research Publication Kennedy

Two Kennedy Institute scientists have proposed a solution to a puzzle of the human immune system: how our immune system scales its response in proportion to any threat to our health to make it 'just right'. Their ideas, published in the journal Trends in Immunology, could support a range of medical research.

Health guidance leads to reduction of repeat hip fractures

Health guidance leads to reduction of repeat hip fractures

Botnar Publication Research

The adoption of new guidance on osteoporosis medication in 2005 may have been responsible for a 22% drop in the number of over-60s suffering a second fracture after a broken hip, an Oxford University study, published in the Journal of Bone and Mineral Research, has found.

Global experts adopt new guidelines for health data analysis

Global experts adopt new guidelines for health data analysis

Research Publication Botnar

Raising the bar in terms of research excellence - the best studies analysing public health data will soon get better.

Poorer patients less likely to get hip replacements

Poorer patients less likely to get hip replacements

Research Publication

Poorer patients and those who require surgery at the weekend are less likely to receive a total hip replacement (THR), despite clear national guidelines setting out who should get one.

NDORMS researchers shine a spotlight on the quality of fall prevention research

NDORMS researchers shine a spotlight on the quality of fall prevention research

Publication Research

Trials Journal showcases a new study by NDORMS researchers showing that fall injury prevention trials fail to use a core outcome set.

Platelet-rich plasma not suitable for routine use in clinical practice

Platelet-rich plasma not suitable for routine use in clinical practice

Publication Research

BMJ publication on platelet-rich plasma injections for musculoskeletal soft tissue injuries advises against routine use in clinical practice and highlights the need for high quality research.

Blood test that could predict arthritis

Blood test that could predict arthritis

Research Publication

Scientists have found a marker that can indicate your likelihood of suffering from rheumatoid arthritis (RA) even sixteen years before the condition takes effect.

Could Aspirin shoulder the burden of inflammation?

Could Aspirin shoulder the burden of inflammation?

Publication Research

Aspirin could be used as an anti-inflammatory drug, bringing relief to the thousands who suffer with shoulder pain, researchers at NDORMS have found.

New hope for patients with Inflammatory Bowel Disease

New hope for patients with Inflammatory Bowel Disease

Publication

A new study led by researchers at the Kennedy Institute and published today in Immunity sheds light on the drivers behind Inflammatory bowel disease (IBD) and suggests potential new targets for treatment of the condition.

New hope for patients with cancer-induced bone diseases

New hope for patients with cancer-induced bone diseases

Research Publication

Researchers at the Kennedy Institute, part of NDORMS have repurposed the approved drug miglustat to successfully slow the progression of multiple myeloma.

Blocking obesity-associated protein stops dangerous fat formation

Blocking obesity-associated protein stops dangerous fat formation

Publication

By changing mouse genes to block a protein associated with obesity, researchers at the Kennedy Institute of Rheumatology, NDORMS have prevented fat from forming around the animals' internal organs, even when the animals eat an unhealthy diet. The study in Nature Medicine found that these genetically engineered mice also retained their sensitivity to insulin (normally blunted by obesity), despite gaining weight.

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