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The latest updates on our research and how it is improving people’s lives.

Improving the reporting of patent landscapes for better decision-making

Improving the reporting of patent landscapes for better decision-making

Botnar Main Publication

An international panel of experts led by NDORMS researchers has developed a reporting guideline which supports the reporting quality of patent landscapes, ultimately promoting better informed decision-making in technology development and research direction.

Getting sample sizes right for clinical trials

Getting sample sizes right for clinical trials

Botnar CSM Main Publication Statistics and epidemiology

New guidance published yesterday by a team led by NDORMS Associate Professor Jonathan Cook will help researchers recruit the right number of people for clinical trials and answer key research questions.

New clinical tool will help patients with acute ankle sprain

New clinical tool will help patients with acute ankle sprain

Botnar CSM Main Publication Rehabilitation and self-management Statistics and epidemiology

Patients arriving at hospital emergency departments with acute ankle sprains can expect more timely advice and follow-up care in future after researchers in Oxford developed a new tool that will aid clinical decisions on treatment.

Muscle weakness costs the UK £2.5 billion

Muscle weakness costs the UK £2.5 billion

Botnar Main Publication Statistics and epidemiology

UK health and social care costs due to muscle weakness amount to around £2.5 billion according to a new study carried out at the University of Oxford and the University of Southampton.

Oxford scientists discover key factor that ‘alerts’ stem cells to accelerate healing of multiple tissues

Oxford scientists discover key factor that ‘alerts’ stem cells to accelerate healing of multiple tissues

Kennedy Main Orthopaedics and trauma Publication Research

Researchers at the Kennedy Institute, University of Oxford have found that a single administration of a molecule accelerated healing of multiple tissues when administered after or even before injury.

‘Life support’ for livers may improve transplants

‘Life support’ for livers may improve transplants

CSM Main Publication Research

Preserving livers at body temperature may improve transplant outcomes and increase viable donor liver numbers, thereby lowering waiting list mortality rates, reports a paper published online this week in Nature.

Study confirms close contact casting offers alternative to surgery in unstable ankle fractures in older people

Study confirms close contact casting offers alternative to surgery in unstable ankle fractures in older people

Botnar Publication RRIO Rehabilitation and self-management Research

A study has confirmed that a new form of casting offers an alternative to invasive surgery in older people who have unstable ankle fractures.

A secreted commensal sugar sweetens the deal for intestinal macrophages

A secreted commensal sugar sweetens the deal for intestinal macrophages

Department Kennedy Main Publication Research

A recent publication from the Powrie group at the Kennedy Institute of Rheumatology has described a novel mechanism by which the commensal pathogen Heliobacter hepaticus maintains its niche in the intestinal environment.

Botnar researchers lead in identifying new inflammatory target in Spondyloarthritis patients

Botnar researchers lead in identifying new inflammatory target in Spondyloarthritis patients

Botnar Inflammation biology Main Publication

Spondyloarthritis encompasses a group of common inflammatory diseases caused by an overactive immune response affecting up to half a million people in the UK alone.

Placebo controlled randomised surgical trial for subacromial shoulder pain

Placebo controlled randomised surgical trial for subacromial shoulder pain

Botnar Main Orthopaedics and trauma Publication SITU

The role of arthroscopic subacromial decompression in the treatment of subacromial shoulder pain (impingement).

Improved outcomes for patients with fracture of the distal tibia

Improved outcomes for patients with fracture of the distal tibia

Main Publication Research Trauma

In a recent study published in The Journal of the American Medical Association (JAMA), research from Oxford Trauma in conjunction with Warwick Clinical Trials Unit shows that intramedullary nail fixation provides better quality of life for patients in the 12 months following a fracture of the distal tibia and costs less than ‘locking’ plate fixation.

ImPAcT of inflammation in Achilles tendinopathy

ImPAcT of inflammation in Achilles tendinopathy

Inflammation biology Main Publication Research

In a new study published in the British Journal of Sports Medicine, scientists at NDORMS investigated if chronic inflammation was a feature of Achilles tendinopathy and rupture.

The benefits and risks of a career in cricket

The benefits and risks of a career in cricket

Main Publication Research

Study of former elite cricketers conducted by scientists at NDORMS highlights the benefits and risks of a career in cricket, including lower heart disease and a high quality of life, but an increased prevalence of osteoarthritis, joint replacement, and mental health conditions.

Blood metal ion thresholds to identify patients with metal-on-metal hip implants at risk of reactions to metal debris

Blood metal ion thresholds to identify patients with metal-on-metal hip implants at risk of reactions to metal debris

Main Orthopaedics and trauma Publication

Research published in The Journal of Bone & Joint Surgery confirms that blood metal ion levels specific to the type of hip implant used can help predict patients who are at low risk of adverse reactions to metal debris (ARMD).

Study highlights high prevalence of hip and knee replacements for former elite rugby players

Study highlights high prevalence of hip and knee replacements for former elite rugby players

Botnar Main Publication Research

In a new study published in journal Scientific Reports, scientists at NDORMS and the University of Bath have identified a high prevalence of osteoarthritis, hip and knee replacement among former elite rugby players.

Autophagy-dependent generation of free fatty acids is critical for normal neutrophil differentiation

Autophagy-dependent generation of free fatty acids is critical for normal neutrophil differentiation

Immunity and microbiome Kennedy Main Publication Research

Recent research from the Simon Group has discovered an unexpected novel role that autophagy plays during the generation of neutrophils.

Targeting tendinopathy resolution

Targeting tendinopathy resolution

Inflammation biology Main Publication Research

In a new study published in journal Scientific Reports, scientists at NDORMS and Queen Mary University of London have identified reasons underpinning the failure of inflammation to resolve in disorders of musculoskeletal soft tissues such as tendons.

Dopamine rewards immune cells through immunological synapse

Dopamine rewards immune cells through immunological synapse

Immunity and microbiome Main Publication Research

Researchers at the Kennedy Institute of Rheumatology at the University of Oxford mapped dopamine and the consequences of its release to the immunological synapse.

Supporting patient safety through best-practice trial design

Supporting patient safety through best-practice trial design

CSM Main Publication Research Statistics and epidemiology

UK statisticians and trialists reach out to the clinical trial community in an awareness-raising paper published this week as a first step in changing practice. They promote the use of adaptive designs in early-phase clinical trials to improve trial efficiency, which will benefit patients.

Link between patient age and risk of revision

Link between patient age and risk of revision

Botnar Main Orthopaedics and trauma Publication Research

Evidence released in the Lancet demonstrates a link between patient age and risk of revision on knee and hip replacements.

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