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The latest updates on our research and how it is improving people’s lives.

‘Life support’ for livers may improve transplants

‘Life support’ for livers may improve transplants

CSM Publication Research

Preserving livers at body temperature may improve transplant outcomes and increase viable donor liver numbers, thereby lowering waiting list mortality rates, reports a paper published online this week in Nature.

Study confirms close contact casting offers alternative to surgery in unstable ankle fractures in older people

Study confirms close contact casting offers alternative to surgery in unstable ankle fractures in older people

Botnar Publication Rehabilitation and self-management Research

A study has confirmed that a new form of casting offers an alternative to invasive surgery in older people who have unstable ankle fractures.

A secreted commensal sugar sweetens the deal for intestinal macrophages

A secreted commensal sugar sweetens the deal for intestinal macrophages

Department Kennedy Publication Research

A recent publication from the Powrie group at the Kennedy Institute of Rheumatology has described a novel mechanism by which the commensal pathogen Heliobacter hepaticus maintains its niche in the intestinal environment.

Botnar researchers lead in identifying new inflammatory target in Spondyloarthritis patients

Botnar researchers lead in identifying new inflammatory target in Spondyloarthritis patients

Botnar Inflammation biology Publication

Spondyloarthritis encompasses a group of common inflammatory diseases caused by an overactive immune response affecting up to half a million people in the UK alone.

Placebo controlled randomised surgical trial for subacromial shoulder pain

Placebo controlled randomised surgical trial for subacromial shoulder pain

Botnar Orthopaedics, tissue engineering and regenerative medicine Publication

The role of arthroscopic subacromial decompression in the treatment of subacromial shoulder pain (impingement).

Improved outcomes for patients with fracture of the distal tibia

Improved outcomes for patients with fracture of the distal tibia

Publication Research Trauma

In a recent study published in The Journal of the American Medical Association (JAMA), research from Oxford Trauma in conjunction with Warwick Clinical Trials Unit shows that intramedullary nail fixation provides better quality of life for patients in the 12 months following a fracture of the distal tibia and costs less than ‘locking’ plate fixation.

ImPAcT of inflammation in Achilles tendinopathy

ImPAcT of inflammation in Achilles tendinopathy

Inflammation biology Publication Research

In a new study published in the British Journal of Sports Medicine, scientists at NDORMS investigated if chronic inflammation was a feature of Achilles tendinopathy and rupture.

Study highlights high prevalence of hip and knee replacements for former elite rugby players

Study highlights high prevalence of hip and knee replacements for former elite rugby players

Botnar Publication Research

In a new study published in journal Scientific Reports, scientists at NDORMS and the University of Bath have identified a high prevalence of osteoarthritis, hip and knee replacement among former elite rugby players.

The benefits and risks of a career in cricket

The benefits and risks of a career in cricket

Publication Research

Study of former elite cricketers conducted by scientists at NDORMS highlights the benefits and risks of a career in cricket, including lower heart disease and a high quality of life, but an increased prevalence of osteoarthritis, joint replacement, and mental health conditions.

Blood metal ion thresholds to identify patients with metal-on-metal hip implants at risk of reactions to metal debris

Blood metal ion thresholds to identify patients with metal-on-metal hip implants at risk of reactions to metal debris

Orthopaedics, tissue engineering and regenerative medicine Publication

Research published in The Journal of Bone & Joint Surgery confirms that blood metal ion levels specific to the type of hip implant used can help predict patients who are at low risk of adverse reactions to metal debris (ARMD).

Autophagy-dependent generation of free fatty acids is critical for normal neutrophil differentiation

Autophagy-dependent generation of free fatty acids is critical for normal neutrophil differentiation

Immunity and microbiome Kennedy Publication Research

Recent research from the Simon Group has discovered an unexpected novel role that autophagy plays during the generation of neutrophils.

Targeting tendinopathy resolution

Targeting tendinopathy resolution

Inflammation biology Publication Research

In a new study published in journal Scientific Reports, scientists at NDORMS and Queen Mary University of London have identified reasons underpinning the failure of inflammation to resolve in disorders of musculoskeletal soft tissues such as tendons.

Dopamine rewards immune cells through immunological synapse

Dopamine rewards immune cells through immunological synapse

Immunity and microbiome Publication Research

Researchers at the Kennedy Institute of Rheumatology at the University of Oxford mapped dopamine and the consequences of its release to the immunological synapse.

Supporting patient safety through best-practice trial design

Supporting patient safety through best-practice trial design

CSM Publication Research Statistics and epidemiology

UK statisticians and trialists reach out to the clinical trial community in an awareness-raising paper published this week as a first step in changing practice. They promote the use of adaptive designs in early-phase clinical trials to improve trial efficiency, which will benefit patients.

Link between patient age and risk of revision

Link between patient age and risk of revision

Botnar Orthopaedics, tissue engineering and regenerative medicine Publication Research

Evidence released in the Lancet demonstrates a link between patient age and risk of revision on knee and hip replacements.

New potential treatment target for patients with inflammatory bowel disease

New potential treatment target for patients with inflammatory bowel disease

Kennedy Publication Research

A new study published today in Nature Medicine could change the lives of millions of people living with inflammatory bowel diseases (IBD) who don’t respond to the current standard of care.

Study offers hope of new treatment for rheumatoid arthritis

Study offers hope of new treatment for rheumatoid arthritis

Botnar Publication Research

Patients who do not respond to current rheumatoid arthritis (RA) treatments may benefit from a new form of treatment that has been shown in a study to be effective against symptoms of the disease.

Better diagnosis for back pain

Better diagnosis for back pain

Awards Publication

Research by Professor Jeremy Fairbank and colleagues, and published in the European Spine Journal, has found automation can improve how we diagnose back problems.

Elderly patients with unstable ankle fractures could avoid surgery

Elderly patients with unstable ankle fractures could avoid surgery

Publication Research

Elderly patients with unstable ankle fractures could avoid surgery, according to research by a UK team led by NDORMS at the Oxford University.

Getting it 'just right' in the immune system

Getting it 'just right' in the immune system

Kennedy Publication Research

Two Kennedy Institute scientists have proposed a solution to a puzzle of the human immune system: how our immune system scales its response in proportion to any threat to our health to make it 'just right'. Their ideas, published in the journal Trends in Immunology, could support a range of medical research.

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