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UK statisticians and trialists reach out to the clinical trial community in an awareness-raising paper published this week as a first step in changing practice. They promote the use of adaptive designs in early-phase clinical trials to improve trial efficiency, which will benefit patients.
Ancestrally Inclusive Musculoskeletal Single-cell (AIMS) Network
Botnar
Creating a global atlas of the musculoskeletal system
Health Economics & Outcomes Research
Arthritis Botnar Orthopaedics and trauma Statistics and epidemiology
Our research aims to improve people's health and wellbeing by making the most efficient use of health and social care resources. To achieve this, we use real-world data and mathematical models to evaluate the costs and consequences of applying different interventions over a period of time, often the entire lifetime of patients.
DRAFT3 – CASP
Botnar OCTRU
This trial aims to compare two treatment methods that are currently standard care for treating wrist fractures. There are a large number of wrist fractures every year in the UK and by comparing the clinical and cost effectiveness of the treatments, this could help save money for the NHS.
HAWAII
Botnar Hand
The HAWAII Feasibility Study: A multi-centre randomised feasibility study to determine the key indicators of feasibility for a definitive trial of antimicrobial sutures versus standard sutures in hand and wrist trauma surgery in adults aged 18 years old and over.
The PHI Lab
Botnar CSM Statistics and epidemiology
Cribbs Group | Computational and Systems Biology
Botnar
Work in the Cribbs lab focuses on developing novel single-cell technology and computational analysis frameworks that empower new modes of treatment for disease.
Mouthuy Group | Soft Tissue Engineering
Botnar
We develop biomaterials and dynamic bioreactor systems for soft tissue repair applications.
CPinBOSS Study
Botnar SITU Trials
CPinBOSS - Cerebral Palsy in the British Orthopaedic Surgery Surveillance Study
Dakin Group | Soft Tissue Joint Disease
Botnar Inflammation biology Orthopaedics and trauma Tissue remodelling and regeneration
The Dakin Group undertakes translational research focusing on identifying the cellular and molecular basis of inflammatory fibrotic soft tissue joint diseases, with research programmes on tendinopathy, frozen shoulder and knee arthrofibrosis. Understanding the cellular and molecular basis of these diseases will inform new therapeutic approaches targeting tissue resident stromal cells of the joint, to promote resolution of inflammatory fibrotic disease.
Hand Research Group
Botnar
We are a collaborative group of academic researchers, therapists, physicians, and surgeons, who work together to understand the epidemiology, pathogenesis, and clinical impact of common hand conditions. Our ultimate aim is to improve the care of patients with hand and wrist problems.
UTMoSt
Botnar Knee
Risk-benefit and costs of unicompartmental (compared to total) knee replacement for patients with multiple co-morbidities: a non-randomised study, and different novel approaches to minimise confounding.
Research Alliance on Women's Health
Botnar
Oxford Bayer Healthcare Collaborative Research Alliance on Women's Health