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OBJECTIVES

Athero-Flux aims to identify, characterise and validate novel therapeutic targets for CVD by dissecting the biosynthesis and pro-atherogenic potential of specific molecular species of SLs identified by lipidomics as strong predictors of CV risk in large-scale clinical studies.

 Specific objectives:

Objective 1: To identify the steps regulating the generation and signalling of specific SLs relevant to CV risk
Objective 2: To validate therapeutic targets in SL metabolism and downstream signalling using atherosclerosis models in vitro and in vivo
Objective 3: To develop clinically applicable LNA-based therapeutics for the treatment of CVD and its acute complications