Dotam derivatives for therapeutic use
LIM N., Hu HY., Nazare M., Ding-Pfenningdorff D., Plettenburg O., Ritzeler O., Juretscheke H-P., Saas J., Bartnik E., Florian P., Wendt U., Schultz C., Nagase H.
The present invention relates to A compound of the formula I, in any of their stereoisomeric forms or a mixture of stereoisomeric forms in any ratio, and the pharmaceutically acceptable salts thereof, (I) wherein M is absent or present and a positively charged metal ion out of the group Gd, Yb, Mn, Cr, Cu, Fe, Pr, Nd, Sm, Tb, Yb, Dy, Ho, Er, Eu, Ga, 68Ga, 64Cu, 99mTc, 177Lu, 67Ga, 111In, 99Mo; and A1, A2, A3 and A4; L1, L2, L3 and L4; Y1, Y2, Y3 and Y4; Z1, Z2, Z3 and Z4 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds and are suitable for the treatment of osteoarthritis. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.