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BACKGROUND: Estrogens and several other endogenous substances are recognised as being important in the process of wound healing. However, the effect of aromatase and aromatase inhibition in the wound healing process has yet to be fully defined. OBJECTIVE: A review of the in vitro and in vivo evidence on the effect of aromatase inhibition on wound healing. METHODS: The primary medical search engines used for the study were Ovid MEDLINE (1950 - March 2009) and EMBASE (1980 - March 2009) databases. RESULTS/CONCLUSION: The delayed healing of cutaneous wounds in aged individuals may in part reflect the decline in circulating levels of dehydroepiandrosterone (DHEA) and estrogens. The beneficial response on wound healing that DHEA and estrogen exert may be blocked by aromatase inhibition. Based on animal models, aromatase inhibitors may adversely affect cutaneous wound healing in the acute setting. So far, there have been no clinical trials investigating the adverse affect of aromatase inhibitors on the process of cutaneous wound healing in humans. Postmenopausal patients who take aromatase inhibitors as an adjunct to breast cancer therapy may, therefore, be at increased risk of delayed wound healing. Further studies are necessary to assess the extent of the effects on the wound healing process.

Original publication

DOI

10.1517/14740330903190674

Type

Journal article

Journal

Expert opin drug saf

Publication Date

09/2009

Volume

8

Pages

523 - 535

Keywords

Adipose Tissue, Aged, Animals, Antineoplastic Agents, Hormonal, Aromatase, Aromatase Inhibitors, Breast Neoplasms, Cells, Cultured, Cytokines, Dehydroepiandrosterone, Drug Evaluation, Preclinical, Estrogens, Extracellular Matrix, Female, Fibroblasts, Humans, Male, Middle Aged, Neovascularization, Pathologic, Neovascularization, Physiologic, Postmenopause, Skin, T-Lymphocytes, Helper-Inducer, Wound Healing