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Peroxide is a strong oxidizing agent and disinfectant frequently used in orthopedic surgery. The authors conducted a systematic literature review of peroxide in orthopedic surgery, evaluating use, complications, efficacy, and appropriate concentrations. One hundred seventy-five reports were identified, with 24 being eligible for analysis. Orthopedic surgeons used peroxide for irrigation and bacterial reduction in various procedures. Complications included cytotoxicity, allergic reactions, suture damage, and inflammation. Use of the standard concentration of 3% peroxide and standard time in situ are without evidence. Laboratory studies suggest that diluted concentrations retain the benefit of bacterial decolonization without increasing the risk for complications. [Orthopedics. 2018; 41(6):e756-e764.].

Original publication

DOI

10.3928/01477447-20181010-07

Type

Journal article

Journal

Orthopedics

Publication Date

01/11/2018

Volume

41

Pages

e756 - e764

Keywords

Anti-Infective Agents, Local, Humans, Orthopedic Procedures, Peroxides, Surgical Wound Infection