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Pseudoporphyria is characterized by erythema, blistering, and scarring on sun-exposed skin. Nonsteroidal antiinflammatory drugs (NSAIDs) are implicated in the etiology of this condition. In a 1-year prospective study of children attending the pediatric rheumatology clinic in Edinburgh we found a prevalence of pseudoporphyria of 10.9% in children taking NSAIDs for juvenile idiopathic arthritis. Naproxen was the most commonly implicated NSAID, independent of dosage. Blue/gray eye color was an independent risk factor for the development of pseudoporphyria. We would advise caution in prescribing naproxen in these children to prevent disfiguring facial scarring.

Original publication




Journal article


Pediatr dermatol

Publication Date





480 - 483


Adolescent, Anti-Inflammatory Agents, Non-Steroidal, Arthritis, Juvenile, Child, Child, Preschool, Cohort Studies, Female, Humans, Male, Naproxen, Porphyrias, Prevalence, Prospective Studies, Risk Factors, Skin