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A number of factors contribute to the pathogenesis of osteoarthritis. Genetic factors are predominant in some cases, including the syndrome of hereditary arthro-ophthalmopathy. The clinical features of the syndrome and the concept of genetic mutations in matrix components are discussed.

Type

Journal article

Journal

Br j rheumatol

Publication Date

12/1994

Volume

33

Pages

1175 - 1180

Keywords

Adult, Aged, Collagen, Eye Diseases, Family Health, Female, Humans, Male, Mutation, Osteoarthritis, Pedigree, Phenotype, Syndrome