Dysregulated inflammation is a central pathological process in diverse disease states. Traditionally, therapeutic approaches have sought to modulate the pro- or anti-inflammatory limbs of inflammation, with mixed success. However, insight into the pathways by which inflammation is resolved has highlighted novel opportunities to pharmacologically manipulate these processes - a strategy that might represent a complementary (and perhaps even superior) therapeutic approach. This Review discusses the state of the art in the biology of resolution of inflammation, highlighting the opportunities and challenges for translational research in this field.
Journal article
Nat rev drug discov
08/2016
15
551 - 567
Animals, Anti-Inflammatory Agents, Disease Models, Animal, Humans, Inflammation, Inflammation Mediators, Mice, Rats, Signal Transduction, Zebrafish