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The three major urinary androgen metabolites, dehydroepiandrosterone (DHEA), androsterone (ANDRO), and aetiocholanolone (AETIO) were measured in 1,484 volunteer women between 29 and 60 years of age on the island of Guernsey from 1962-1967. Twelve of these women subsequently developed ovarian cancer after a median interval of 130 months and a minimum interval of 19 months. All three androgen levels in these women were lower than those in controls matched for age and menopausal status. The results were most striking for DHEA, where half of the cases were below the 27th percentile of their matched controls (p = 0.007, two-sided). The results for ANDRO were of marginal significance (p = 0.06), and those for AETIO were not significant (p = 0.33).

Original publication

DOI

10.1002/ijc.2910320611

Type

Journal article

Journal

Int j cancer

Publication Date

15/12/1983

Volume

32

Pages

723 - 726

Keywords

Adult, Androgens, Androsterone, Dehydroepiandrosterone, Etiocholanolone, Female, Humans, Middle Aged, Ovarian Neoplasms, Prospective Studies, Risk