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Group-sequential tests may be applied to trials in which the number of patients is fixed, a response variable is measured for each patient at successive follow-up visits, and the accumulated responses are compared across treatment groups. The standard theory is inapplicable because the increments in the accumulated responses are no longer independent. An adjustment can be made to allow for the ratio of between-patient to within-patient variance and for possible first-order autocorrelation. The method is illustrated by reference to a dental trial.

Type

Journal article

Journal

Biometrics

Publication Date

06/1985

Volume

41

Pages

353 - 359

Keywords

Biometry, Clinical Trials as Topic, Humans, Regression Analysis, Time Factors