Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Rheumatoid arthritis (RA) is a multiorgan chronic inflammatory condition that affects >430,000 people in the UK, constituting approximately 0.84% of the UK population. The cardinal clinical feature is a symmetrical polyarthritis that predominantly affects the small joints. RA can affect other components of the musculoskeletal system (bursitis, tendinopathy, muscle atrophy, osteoporosis) and almost every organ in the body. Extra-articular manifestations of RA can be cutaneous, haematological, neurological, pulmonary, cardiac, renal and ocular. A better understanding of the varied clinical aspects of RA is vital to instigating appropriate management. This review provides a detailed description of the clinical manifestations of RA, both musculoskeletal and extra-articular.

Original publication




Journal article


Medicine (united kingdom)

Publication Date