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The diagnosis of prosthetic joint infection (PJI) in the routine microbiology laboratory is labour-intensive, but semi-automated methods may be appropriate. We prospectively compared four microbiological culture methods on samples taken at prosthetic joint revision surgery. Automated BACTEC blood culture bottles and cooked meat enrichment broth were the most sensitive methods (87% and 83%, respectively, as compared with fastidious anaerobic broth (57%) and direct plates (39%)); all were highly specific (97-100%). To our knowledge, this is the first prospective study aimed at comparing culture methods in routine use in UK clinical laboratories for the diagnosis of PJI.

Original publication

DOI

10.1111/j.1469-0691.2011.03597.x

Type

Journal article

Journal

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

Publication Date

10/2011

Volume

17

Pages

1528 - 1530

Addresses

Department of Microbiology, Oxford Radcliffe Hospitals, Oxford, UK. harriethughes@doctors.org.uk

Keywords

Humans, Bacteria, Prosthesis-Related Infections, Culture Media, Bacteriological Techniques, Microbial Sensitivity Tests, Sensitivity and Specificity, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Young Adult