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Malaria infection reduces the binding capacity of benzodiazepine receptors in mice. We studied the efficacy of diazepam terminating seizures in children with falciparum malaria. Diazepam stopped seizures in fewer patients with malaria parasitaemia (chi(2)=3.93, P=0.047) and those with clinical diagnosis of malaria (chi(2)=9.84, P=0.002) compared to those without. However malaria was not identified as an independent risk factor for diazepam's failure to stop seizures in children.

Original publication

DOI

10.1016/j.eplepsyres.2008.08.002

Type

Journal article

Journal

Epilepsy research

Publication Date

12/2008

Volume

82

Pages

215 - 218

Addresses

Kenya Medical Research Institute (KEMRI)/Welcome Trust Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya. Mikumi@kilifi.kemri-wellcome.org

Keywords

Humans, Parasitemia, Malaria, Cerebral, Malaria, Falciparum, Epilepsy, Paraldehyde, Diazepam, Histidine, Receptors, GABA-A, Anticonvulsants, Injections, Intravenous, Risk Factors, Retrospective Studies, Child, Child, Preschool, Infant, Female, Male