Steijvers E., Shi Y., Lu H., Zhang W., Zhang Y., Zhao F., Wang B., Hughes L., Barralet JE., Degli-Alessandrini G., Kraev I., Johnston R., Shao Z., Ebetino FH., Triffitt JT., Russell RGG., Deganello D., Cao X., Xia Z.

Biomaterials are widely used as orthopaedic implants and bone graft substitutes. We aimed to develop a rapid osteogenic assessment method using a murine tibial periosteal ossification model to evaluate the bone formation/remodelling potential of a biomaterial within 2-4 weeks. A novel hydroxyapatite/aragonite (HAA) biomaterial was implanted into C57BL/6 mice juxtaskeletally between the tibia and tibialis anterior muscle. Rapid intramembranous bone formation was observed at 14 days, with 4- to 8-fold increases in bone thickness and callus volume in comparison with sham-operated animals (p

Rapid assessment of the osteogenic capacity of hydroxyapatite/aragonite using a murine tibial periosteal ossification model.

Steijvers E., Shi Y., Lu H., Zhang W., Zhang Y., Zhao F., Wang B., Hughes L., Barralet JE., Degli-Alessandrini G., Kraev I., Johnston R., Shao Z., Ebetino FH., Triffitt JT., Russell RGG., Deganello D., Cao X., Xia Z.

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