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Publication bias has been previously identified as a threat to the validity of a meta-analysis. Recently, new evidence has documented an additional threat to validity, the selective reporting of trial outcomes within published studies. Several diseases have several possible measures of outcome. Some articles might report only a selection of those outcomes, perhaps those with statistically significant results. In this article, we review this problem while addressing the questions: what is within-study selective reporting? how common is it? why is it done? how can it mislead? how can it be detected?, and finally, what is the solution? We recommend that both publication bias and selective reporting should be routinely investigated in systematic reviews.

Original publication

DOI

10.1191/0962280205sm415oa

Type

Journal article

Journal

Stat Methods Med Res

Publication Date

10/2005

Volume

14

Pages

515 - 524

Keywords

Bias (Epidemiology), Clinical Trials as Topic, Humans, Meta-Analysis as Topic, Outcome Assessment (Health Care), Publications, Reproducibility of Results, United Kingdom