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The rapidly increasing research activity focused on chromatin-mediated regulation of epigenetic mechanisms is generating waves of data on writers, readers and erasers of the histone code, such as protein methyltransferases, bromodomains or histone deacetylases. To make these data easily accessible to communities of research scientists coming from diverse horizons, we have created ChromoHub, an online resource where users can map on phylogenetic trees disease associations, protein structures, chemical inhibitors, histone substrates, chromosomal aberrations and other types of data extracted from public repositories and the published literature. The interface can be used to define the structural or chemical coverage of a protein family, highlight domain architectures, interrogate disease relevance or zoom in on specific genes for more detailed information. This open-access resource should serve as a hub for cell biologists, medicinal chemists, structural biologists and other navigators that explore the biology of chromatin signalling.http://www.thesgc.org/chromohub/.

Type

Journal

Bioinformatics (Oxford, England)

Publication Date

08/2012

Volume

28

Pages

2205 - 2206

Addresses

Structural Genomics Consortium, University of Toronto, Toronto, ON M5G1L7, Canada.

Keywords

Chromatin, Histone Deacetylases, Protein Methyltransferases, Histones, Phylogeny, Gene Expression Regulation, Epigenesis, Genetic, Histone Code, Software, User-Computer Interface, Databases, Genetic