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We have reported that angiogenic primary breast carcinoma can relapse not only as angiogenic, but also as non-angiogenic, lung metastases. This non-angiogenic pathway seems to be a novel pathway of cancer progression, and such tumours are likely to be resistant to antiangogenic treatment.

Type

Journal article

Journal

Lancet (London, England)

Publication Date

05/2000

Volume

355

Pages

1787 - 1788

Keywords

Humans, Breast Neoplasms, Lung Neoplasms, Lymphatic Metastasis, Neovascularization, Pathologic