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Prognostic factor research aims to identify factors associated with subsequent clinical outcome in people with a particular disease or health condition. In this article, the second in the PROGRESS series, the authors discuss the role of prognostic factors in current clinical practice, randomised trials, and developing new interventions, and explain why and how prognostic factor research should be improved.


Journal article


PLoS medicine

Publication Date





School of Health and Population Sciences, University of Birmingham, Birmingham, United Kingdom.


PROGRESS Group, Humans, Disease Progression, Biological Markers, Prognosis, Treatment Outcome, Risk Assessment, Risk Factors, Predictive Value of Tests, Decision Support Techniques, Biomedical Research, Research Design, Health Services Research, Randomized Controlled Trials as Topic