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Prognostic factor research aims to identify factors associated with subsequent clinical outcome in people with a particular disease or health condition. In this article, the second in the PROGRESS series, the authors discuss the role of prognostic factors in current clinical practice, randomised trials, and developing new interventions, and explain why and how prognostic factor research should be improved.

Original publication




Journal article


Plos med

Publication Date





Biomarkers, Biomedical Research, Decision Support Techniques, Disease Progression, Health Services Research, Humans, Predictive Value of Tests, Prognosis, Randomized Controlled Trials as Topic, Research Design, Risk Assessment, Risk Factors, Treatment Outcome