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The INTERGROWTH-21(st) Project has in its mandate to develop prescriptive standards for fetal, neonatal and preterm post-neonatal growth. The project comprises three components: the Fetal Growth Longitudinal Study (FGLS), the Preterm Postnatal Follow-up Study (PPFS), and the Newborn Cross-Sectional Study (NCSS). We consider here the statistical aspects of the three components as they relate to the construction of these standards, in particular the sample size, and outline the principles that will guide the planned main analyses.

Original publication




Journal article



Publication Date



120 Suppl 2


71 - v


Sample size, fetal growth, longitudinal study, prescriptive standards, INTERGROWTH-21st, statistical aspects, Body Weights and Measures, Child Development, Clinical Protocols, Cross-Sectional Studies, Data Interpretation, Statistical, Fetal Development, Growth Charts, Humans, Infant, Infant, Newborn, Longitudinal Studies, Models, Statistical, Multicenter Studies as Topic, Research Design, Sample Size, Ultrasonography, Prenatal