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A recently commercialised hydroxyapatite electrochemically assisted chemical deposition technique (BoneMaster) has been shown to induce increased bone apposition; whether this response is caused by the surface topography or chemistry is unknown. An in-vitro examination using human osteoblast-like cells was performed on a series of BoneMaster-coated surfaces. The chemistry was separated from the topography using a thin gold coating; Thermanox coverslips were used as a control. BoneMaster surfaces showed significantly greater alkaline phosphatase activity and osteocalcin production compared with controls; however, no difference was found between the gold-coated and uncoated BoneMaster samples, indicating topography is the main contributing factor.

Original publication




Journal article


J Biomater Appl

Publication Date





946 - 953


Fixation, bone, chemistry, hydroxyapatite, surface, topography, Alkaline Phosphatase, Cell Line, Tumor, Coated Materials, Biocompatible, Durapatite, Electrochemical Techniques, Humans, Osteoblasts, Photoelectron Spectroscopy, Surface Properties