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We report the imaging of tendon with Interferometric Second Harmonic Generation microscopy. We observe that the noncentrosymmetric structural organization can be maintained along the fibrillar axis over more than 150 μm, while in the transverse direction it is ∼1-15 μm. Those results are explained by modeling tendon as a heterogeneous distribution of noncentrosymmetric nano-cylinders (collagen fibrils) oriented along the fibrillar axis. The preservation of the noncentrosymmetric structural organization over multiple tens of microns reveals that tendon is made of domains in which the ratio between fibrils with positive and negative polarity is unbalanced.

Original publication

DOI

10.1002/jbio.201300036

Type

Journal article

Journal

Journal of biophotonics

Publication Date

08/2014

Volume

7

Pages

638 - 646

Addresses

Institut National de la Recherche Scientifique, Centre Énergie Matériaux Télécommunications, 1650 Boulevard Lionel-Boulet, Varennes, QC, J3X1S2, Canada.

Keywords

Tendons, Animals, Mice, Inbred C57BL, Mice, Microscopy, Interferometry, Models, Theoretical, Male