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We looked at our HIV + slow progressors cohort to determine if there were any human leukocyte antigen (HLA) correlates for protection. No statistically significant allelic differences were found between the HIV + and control cohorts using regression analysis, though trends were noted. Data for Elite Controllers showed an increased frequency of B*57. Likewise, no correlation was inferred with the clinical data of the HIV + cohort. We hypothesize that the protective effect of HLA alleles may have been lost over time.

Original publication

DOI

10.1097/qad.0000000000000011

Type

Journal article

Journal

AIDS (London, England)

Publication Date

11/2013

Volume

27

Pages

2822 - 2824

Addresses

aNuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK bBeijing You'An Hospital, Capital Medical University, Beijing, China cCentre for Statistics in Medicine, Oxford, UK dSchool of Public Health, Sun Yat-sen University, Guangzhou, China eMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK fBeijing Ditan Hospital, Capital Medical University, Beijing, China. *Marie-E. Blais and Ke Yi Xu contributed equally to the writing of this article.

Keywords

Humans, HIV Infections, Phosphoproteins, Cohort Studies, Gene Frequency, HIV Long-Term Survivors, China