Synthetic glucocorticoids (GCs) are frequently used to treat painful and inflamed tissues and joints. However GCs also cause unwanted side effects, inhibiting cell proliferation as well as normal cell activity. Whether these effects are transient or long-term is unknown. Inhibition of cell proliferation can lead to either quiescence or senescence. Whereas quiescence is reversible, senescence is irreversible in vivo and hence leads to a permanent loss of normal cell functionality.
Osteoarthritis and cartilage
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