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We report changes in the cytosolic Ca2+ concentration ([Ca2+]i) of single rat osteoclasts in response to Ca2+ receptor activation by micromolar concentrations of the lanthanide metal cation, La3+. The extracellular application of La3+ induced a concentration-dependent elevation of cytosolic [Ca2+]. Prior conditioning of osteoclasts with La3+ resulted in a concentration-dependent reduction of the response to a subsequent application of a maximally effective concentration of Ni2+, a known agonist of the osteoclast Ca2+ receptor. The results establish that the osteoclast Ca2+ receptor is highly sensitive to activation and inactivation by the trivalent cation, La3+.


Journal article


Biochem biophys res commun

Publication Date





907 - 912


Animals, Animals, Newborn, Calcium, Calcium-Binding Proteins, Cytosol, Lanthanum, Nickel, Osteoclasts, Rats, Rats, Inbred Strains, Spectrometry, Fluorescence