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We report changes in the cytosolic Ca2+ concentration ([Ca2+]i) of single rat osteoclasts in response to Ca2+ receptor activation by micromolar concentrations of the lanthanide metal cation, La3+. The extracellular application of La3+ induced a concentration-dependent elevation of cytosolic [Ca2+]. Prior conditioning of osteoclasts with La3+ resulted in a concentration-dependent reduction of the response to a subsequent application of a maximally effective concentration of Ni2+, a known agonist of the osteoclast Ca2+ receptor. The results establish that the osteoclast Ca2+ receptor is highly sensitive to activation and inactivation by the trivalent cation, La3+.

Original publication

DOI

10.1016/0006-291x(92)91283-v

Type

Journal article

Journal

Biochemical and biophysical research communications

Publication Date

09/1992

Volume

187

Pages

907 - 912

Addresses

Bone and Mineral Metabolism Unit, St. George's Hospital Medical School, London.

Keywords

Cytosol, Osteoclasts, Animals, Rats, Inbred Strains, Animals, Newborn, Rats, Lanthanum, Calcium, Nickel, Calcium-Binding Proteins, Spectrometry, Fluorescence