Generating iPSCs: translating cell reprogramming science into scalable and robust biomanufacturing strategies.
Silva M., Daheron L., Hurley H., Bure K., Barker R., Carr AJ., Williams D., Kim H-W., French A., Coffey PJ., Cooper-White JJ., Reeve B., Rao M., Snyder EY., Ng KS., Mead BE., Smith JA., Karp JM., Brindley DA., Wall I.
Induced pluripotent stem cells (iPSCs) have the potential to transform drug discovery and healthcare in the 21(st) century. However, successful commercialization will require standardized manufacturing platforms. Here we highlight the need to define standardized practices for iPSC generation and processing and discuss current challenges to the robust manufacture of iPSC products.