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Maximization of the anabolic effects of intermittent administration of parathyroid hormone (PTH) has recently been at the forefront of clinical research in the area of osteoporosis, with the 'anabolic window' concept as its main driving force. The outcome of these attempts, however, has not been encouraging. This article examines whether the concept itself is based on sound evidence, related pathophysiological aspects, and whether the new anti-sclerostin antibodies could have extended anabolic action.

Original publication

DOI

10.1016/j.tem.2015.01.004

Type

Journal article

Journal

Trends in endocrinology and metabolism: TEM

Publication Date

03/2015

Volume

26

Pages

111 - 113

Addresses

Institute of Musculoskeletal Sciences, Oxford University, Oxford OX3 7LD, UK. Electronic address: Michael.Pazianas@ndorms.ox.ac.uk.

Keywords

Bone and Bones, Humans, Osteoporosis, Parathyroid Hormone, Anabolic Agents, Bone Density