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Patient-reported outcome (PRO) measures (PROMs) are standard measures in the assessment of colorectal cancer (CRC) treatment, but the range and complexity of available PROMs may be hindering the synthesis of evidence. This systematic review aimed to: (i) summarize PROMs in studies of CRC surgery and (ii) categorize PRO content to inform the future development of an agreed minimum 'core' outcome set to be measured in all trials.All PROMs were identified from a systematic review of prospective CRC surgical studies. The type and frequency of PROMs in each study were summarized, and the number of items documented. All items were extracted and independently categorized by content by two researchers into 'health domains', and discrepancies were discussed with a patient and expert. Domain popularity and the distribution of items were summarized.Fifty-eight different PROMs were identified from the 104 included studies. There were 23 generic, four cancer-specific, 11 disease-specific and 16 symptom-specific questionnaires, and three ad hoc measures. The most frequently used PROM was the EORTC QLQ-C30 (50 studies), and most PROMs (n = 40, 69%) were used in only one study. Detailed examination of the 50 available measures identified 917 items, which were categorized into 51 domains. The domains comprising the most items were 'anxiety' (n = 85, 9.2%), 'fatigue' (n = 67, 7.3%) and 'physical function' (n = 63, 6.9%). No domains were included in all PROMs.There is major heterogeneity of PRO measurement and a wide variation in content assessed in the PROMs available for CRC. A core outcome set will improve PRO outcome measurement and reporting in CRC trials.

Original publication

DOI

10.1111/codi.13021

Type

Journal article

Journal

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

Publication Date

11/2015

Volume

17

Pages

O217 - O229

Addresses

Severn School of Surgery, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.

Keywords

CONSENSUS-CRC (Core Outcomes and iNformation SEts iN SUrgical Studies - ColoRectal Cancer) Working Group, Humans, Colorectal Neoplasms, Colorectal Surgery, Self Report, Patient Outcome Assessment, Surveys and Questionnaires