Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The c-erbB-2 gene is overexpressed in about 20% of human breast cancers. Four hundred and eighty-three cases previously examined by immunohistochemical staining for c-erbB-2 expression were analysed to assess the risk associated with the elevated protein expression. Oncoprotein expression was correlated with increasing tumour grade but not with oestrogen receptor status, nodal involvement, tumour size or age. There was an increased risk of relapse and death associated with c-erbB-2 expression irrespective of nodal involvement. This marker thus appears to be a significant prognostic factor in the early as well as the late stages of breast cancer.

Original publication

DOI

10.1038/bjc.1991.100

Type

Journal article

Journal

British journal of cancer

Publication Date

03/1991

Volume

63

Pages

434 - 438

Addresses

Imperial Cancer Research Fund Molecular Oncology Group, Hammersmith Hospital, London, UK.

Keywords

Humans, Breast Neoplasms, Lymphatic Metastasis, Receptor, erbB-2, Proto-Oncogene Proteins, Prognosis, Risk Factors, Proto-Oncogenes, Survival, Adult, Aged, Aged, 80 and over, Middle Aged