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BACKGROUND AND OBJECTIVE: To determine the efficacy of atorvastatin in reducing hard exudates and diabetic macular edema. PATIENTS AND METHODS: An uncontrolled clinical case series included 18 eyes with diabetic maculopathy and an elevated baseline lipid profile. All patients were treated with atorvastatin. Ophthalmologic evaluation, including fundus photography and fluorescein angiography, was performed at presentation and repeated at 3, 6, and 12 months. Hard exudates, hemorrhages, and fluorescein leakage at 12 months were evaluated and compared with baseline findings. RESULTS: Eighteen subjects with diabetic maculopathy received atorvastatin, and a significant decrease in total cholesterol and low-density lipoprotein cholesterol was seen (P < .05). Hard exudates and fluorescein leakage were decreased. No evidence of an association between change in hemorrhage status and treatment was found. CONCLUSION: Oral atorvastatin therapy in patients with diabetes mellitus and dyslipidemia seems to reduce the severity of hard exudates and fluorescein leakage in diabetic maculopathy and could be useful as an adjuvant therapy in the management of diabetic macular edema.

Original publication




Journal article


Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye

Publication Date





316 - 322


Retina Service, Department of Ophthalmology, University Hospital of Heraklion, Crete, Greece.


Fundus Oculi, Humans, Diabetic Retinopathy, Hypercholesterolemia, Diabetes Complications, Pyrroles, Cholesterol, Hemoglobin A, Glycosylated, Heptanoic Acids, Anticholesteremic Agents, Fluorescein Angiography, Treatment Outcome, Administration, Oral, Follow-Up Studies, Prospective Studies, Visual Acuity, Aged, Middle Aged, Female, Male, Macular Edema